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ZBTB34 is a hepatocellular carcinoma-associated protein with a monopartite nuclear localization signal
In conclusion, ZBTB34 is a hepatocellular carcinoma-associated protein with a monopartite NLS. The nuclear import of ZBTB34 is mediated by importin α1, importin α3, importin α4, and importin β1. ZBTB34 performs its biological functions via a putative miR-125b-5p/ZBTB34/(ZBTB10, POLR1B, and AUH) signaling axis in HepG2 cells.PMID:37650557 | DOI:10.18632/aging.204987
Source: Aging - August 31, 2023 Category: Biomedical Science Authors: Zheng Liu Di Jin Xinran Wei Yue Gao Xiaodie Gao Xia Li Xiujuan Wang Pingying Wei Tao Liu Source Type: research

A pancancer analysis of the oncogenic role of ZNRF2 in human tumours
J Cell Mol Med. 2023 Aug 8. doi: 10.1111/jcmm.17900. Online ahead of print.ABSTRACTFinding effective treatments for cancer requires a thorough understanding of how it develops and progresses. Recent research has revealed the crucial role that Zinc and ring finger 2 (ZNRF2) play in the progression of non-small cell lung cancer (NSCLC) by controlling cell growth and death. However, a comprehensive analysis of ZNRF2's role in cancer as a whole has yet to be conducted. Our study sought to investigate the impact of ZNRF2 on diverse human tumours, as well as the molecular pathways involved, using databases such as TCGA (The Canc...
Source: J Cell Mol Med - August 8, 2023 Category: Molecular Biology Authors: Fujie Shi Yunfei Wu Kai Wang Jiafan Wang Minghui Liu Xinlei Sun Source Type: research

CYP2E1 triggered GRP78/ATF6/CHOP signalling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma
Arch Biochem Biophys. 2023 Jul 25:109701. doi: 10.1016/j.abb.2023.109701. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide. Cytochrome P450 2E1 (CYP2E1) is an enzyme, primarily involved in the metabolism of xenobiotics and procarcinogens. The present study was designed to investigate the potential role of CYP2E1 triggered endoplasmic reticulum stress in the progression of HCC through inhibition of apoptosis. In vitro CYP2E1 promotes HepG2 cell migration, reduced chromatin condensation, enhanced intracellular ROS accumulation and induce cell cycle progressio...
Source: Archives of Biochemistry and Biophysics - July 27, 2023 Category: Biochemistry Authors: Sharmeen Ishteyaque Karan Singh Yadav Smriti Verma Kaveri R Washimkar Madhav Nilakanth Mugale Source Type: research

ZNF765 is a prognostic biomarker of hepatocellular carcinoma associated with cell cycle, immune infiltration, m < sup > 6 < /sup > A modification, and drug susceptibility
In conclusion, ZNF765 may be a prognostic biomarker related to cell cycle, immune infiltration, m6A modification, and drug sensitivity for hepatocellular carcinoma.PMID:37400985 | DOI:10.18632/aging.204827
Source: Aging - July 4, 2023 Category: Biomedical Science Authors: Yongqi Ding Yiyang Gong Hong Zeng Gelin Song Zichuan Yu Bidong Fu Yue Liu Da Huang Yanying Zhong Source Type: research

ZNF655 promotes the progression of hepatocellular carcinoma through PSMB8
This study aims to investigate the role of ZNF655, a member of the zinc finger protein family, in the development of HCC. Immunohistochemical staining analysis was conducted to evaluate the expression of ZNF655 in HCC patient samples. Lentivirus-mediated ZNF655 knockdown was established in HCC cell lines (BEL-7402 and HCCLM3). The effects of ZNF655 on different aspects of HCC cell behavior such as proliferation, apoptosis, cycle, migration and tumor formation were examined. Downstream targets of ZNF655 in HCC were identified and verified through loss/gain-of-function experiments. Clinically, ZNF655 expression was elevated ...
Source: Cell Biology International - June 5, 2023 Category: Cytology Authors: Shasha Fan Yu Liu Zhenhai Lin Yongfa Zhang Ning Zhang Yiming Zhao Jiaming Zhou Anrong Mao Longrong Wang Yun Feng Xigan He Lu Wang Qi Pan Source Type: research

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