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Condition: Cholesterol
Cancer: Hepatocellular Carcinoma
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Total 358 results found since Jan 2013.
Gypenosides suppress hepatocellular carcinoma cells by blocking cholesterol biosynthesis through inhibition of MVA pathway enzyme HMGCS1
Chem Biol Interact. 2023 Aug 19:110674. doi: 10.1016/j.cbi.2023.110674. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is one of the most common malignant tumors with high morbidity and mortality. Targeting abnormal cholesterol metabolism is a potential therapeutic direction. Therefore, more natural drugs targeting cholesterol in HCC need to be developed. Gypenosides (Gyp), the major constituent of Gynostemma pentaphyllum, has been demonstrated to have pharmacological properties on anti-cancer, anti-obesity, and hepatoprotective. We investigated whether Gyp, isolated and purified by our lab, could inhibit HCC...
Source: Chemico-Biological Interactions - August 21, 2023 Category: Molecular Biology Authors: Man-Yu Xiao Fang-Fang Li Peng Xie Yan-Shuang Qi Jin-Bo Xie Wen-Jing Pei Hao-Tian Luo Mei Guo Yu-Long Gu Xiang-Lan Piao Source Type: research
Tartary buckwheat root polysaccharides ameliorate non-alcoholic fatty liver disease via the IL6-SOCS3-SREBP1c pathway
Food Chem Toxicol. 2023 Aug 19:113997. doi: 10.1016/j.fct.2023.113997. Online ahead of print.ABSTRACTOur previous study demonstrated that Tartary buckwheat root polysaccharides (TBRP) could reduce insulin resistance in diabetes mellitus by inhibiting SOCS3-stimulated IRS1 protein degradation. However, whether TBRP has the efficiency to treat non-alcoholic fatty liver disease (NAFLD) is still undetermined. This investigation aimed to examine the effects of TBRP on a high-fat diet (HFD)-triggered NAFLD, and elucidate the underlying molecular mechanisms. Briefly, TBRP toxicity in hepatoma (BEL7404) and pancreatic cancer (BxPC...
Source: Food and Chemical Toxicology - August 21, 2023 Category: Food Science Authors: Litao Zhang Shuo Wang Yimin Li Boyu Liu Zeyu Duan Fei Liu Qiang Ren Source Type: research
Gypenosides suppress hepatocellular carcinoma cells by blocking cholesterol biosynthesis through inhibition of MVA pathway enzyme HMGCS1
Chem Biol Interact. 2023 Aug 19:110674. doi: 10.1016/j.cbi.2023.110674. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is one of the most common malignant tumors with high morbidity and mortality. Targeting abnormal cholesterol metabolism is a potential therapeutic direction. Therefore, more natural drugs targeting cholesterol in HCC need to be developed. Gypenosides (Gyp), the major constituent of Gynostemma pentaphyllum, has been demonstrated to have pharmacological properties on anti-cancer, anti-obesity, and hepatoprotective. We investigated whether Gyp, isolated and purified by our lab, could inhibit HCC...
Source: Chemico-Biological Interactions - August 21, 2023 Category: Molecular Biology Authors: Man-Yu Xiao Fang-Fang Li Peng Xie Yan-Shuang Qi Jin-Bo Xie Wen-Jing Pei Hao-Tian Luo Mei Guo Yu-Long Gu Xiang-Lan Piao Source Type: research
Tartary buckwheat root polysaccharides ameliorate non-alcoholic fatty liver disease via the IL6-SOCS3-SREBP1c pathway
Food Chem Toxicol. 2023 Aug 19:113997. doi: 10.1016/j.fct.2023.113997. Online ahead of print.ABSTRACTOur previous study demonstrated that Tartary buckwheat root polysaccharides (TBRP) could reduce insulin resistance in diabetes mellitus by inhibiting SOCS3-stimulated IRS1 protein degradation. However, whether TBRP has the efficiency to treat non-alcoholic fatty liver disease (NAFLD) is still undetermined. This investigation aimed to examine the effects of TBRP on a high-fat diet (HFD)-triggered NAFLD, and elucidate the underlying molecular mechanisms. Briefly, TBRP toxicity in hepatoma (BEL7404) and pancreatic cancer (BxPC...
Source: Food and Chemical Toxicology - August 21, 2023 Category: Food Science Authors: Litao Zhang Shuo Wang Yimin Li Boyu Liu Zeyu Duan Fei Liu Qiang Ren Source Type: research
Gypenosides suppress hepatocellular carcinoma cells by blocking cholesterol biosynthesis through inhibition of MVA pathway enzyme HMGCS1
Chem Biol Interact. 2023 Aug 19:110674. doi: 10.1016/j.cbi.2023.110674. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is one of the most common malignant tumors with high morbidity and mortality. Targeting abnormal cholesterol metabolism is a potential therapeutic direction. Therefore, more natural drugs targeting cholesterol in HCC need to be developed. Gypenosides (Gyp), the major constituent of Gynostemma pentaphyllum, has been demonstrated to have pharmacological properties on anti-cancer, anti-obesity, and hepatoprotective. We investigated whether Gyp, isolated and purified by our lab, could inhibit HCC...
Source: Chemico-Biological Interactions - August 21, 2023 Category: Molecular Biology Authors: Man-Yu Xiao Fang-Fang Li Peng Xie Yan-Shuang Qi Jin-Bo Xie Wen-Jing Pei Hao-Tian Luo Mei Guo Yu-Long Gu Xiang-Lan Piao Source Type: research
Tartary buckwheat root polysaccharides ameliorate non-alcoholic fatty liver disease via the IL6-SOCS3-SREBP1c pathway
Food Chem Toxicol. 2023 Aug 19;179:113997. doi: 10.1016/j.fct.2023.113997. Online ahead of print.ABSTRACTOur previous study demonstrated that Tartary buckwheat root polysaccharides (TBRP) could reduce insulin resistance in diabetes mellitus by inhibiting SOCS3-stimulated IRS1 protein degradation. However, whether TBRP has the efficiency to treat non-alcoholic fatty liver disease (NAFLD) is still undetermined. This investigation aimed to examine the effects of TBRP on a high-fat diet (HFD)-triggered NAFLD, and elucidate the underlying molecular mechanisms. Briefly, TBRP toxicity in hepatoma (BEL7404) and pancreatic cancer (...
Source: Food and Chemical Toxicology - August 21, 2023 Category: Food Science Authors: Litao Zhang Shuo Wang Yimin Li Boyu Liu Zeyu Duan Fei Liu Qiang Ren Source Type: research
A positive feedback between cholesterol synthesis and the pentose phosphate pathway rather than glycolysis promotes hepatocellular carcinoma
This study identified a previously undescribed positive feedback loop between cholesterol synthesis and the PPP, which drives HCC, while microRNA-206 prevents HCC by disrupting this loop. Cholesterol synthesis as a process rather than cholesterol itself is the major contributor of HCC.PMID:37596320 | DOI:10.1038/s41388-023-02757-9
Source: Cancer Control - August 18, 2023 Category: Cancer & Oncology Authors: Junjie Hu Ningning Liu David Song Clifford J Steer Guohua Zheng Guisheng Song Source Type: research
FGF9 Recruits β-Catenin to Increase Hepatic ECM Synthesis and Promote NASH-Driven HCC
This study finds that FGF9 is increased in patients with NASH-associated HCC. Furthermore, NASH-driven HCC mice models by feeding wildtype mice with high-fat/high-cholesterol (HFHC) diet and low dose carbon tetrachloride (CCl4 ) treatment is established; and identified that hepatic FGF9 is increased; with severe fibrosis. Additionally, AAV-mediated knockdown of FGF9 reduced the hepatic tumor burden of NASH-driven HCC mice models. Hepatocyte-specific FGF9 transgenic mice (FGF9Alb ) fed with a HFHC diet without CCl4 treatment exhibited an increased hepatic ECM and tumor burden. However, XAV-939 treatment blocked ECM accumula...
Source: Adv Data - August 11, 2023 Category: Epidemiology Authors: Lei Zhang Qing Zhang Da Teng Manyu Guo Kechao Tang Zhenglin Wang Xiang Wei Li Lin Xiaomin Zhang Xiuyun Wang Dake Huang Cuiping Ren Qingsong Yang Wenjun Zhang Yong Gao Wei Chen Yongsheng Chang Huabing Zhang Source Type: research
Synthesis and potential antidiabetic and lipid-lowering activities of putative asperidine B and its desmethyl analogue
Bioorg Med Chem Lett. 2023 Aug 6;93:129437. doi: 10.1016/j.bmcl.2023.129437. Online ahead of print.ABSTRACTPutative asperidine B is an unnatural 2,6-disubstituted piperidin-3-ol and a structural isomer of (+)-preussin, a well-known pyrrolidin-3-ol alkaloid. This work reports the first enantioselective synthesis of putative asperidine B and its desmethyl analogue via a chiron approach starting from d-isoascorbic acid as well as evaluation of their free-radical scavenging, antidiabetic, and anti-hyperlipidemic activities. Both putative asperidine B and its desmethyl analogue markedly reduced the total reactive oxygen species...
Source: Bioorganic and Medicinal Chemistry Letters - August 7, 2023 Category: Chemistry Authors: Kittisak Thongpat Pannita Holasut Atcharaporn Ontawong Jakkapong Inchai Acharaporn Duangjai Vatcharin Rukachaisirikul Chutima S Vaddhanaphuti Kwanruthai Tadpetch Source Type: research
Combination of transcatheter arterial chemoembolization and anti-PD-L1 liposomes therapy suppressed hepatocellular carcinoma progression in mice
CONCLUSION: Combination of transcatheter arterial chemoembolization and anti-PD-L1 liposome drug therapy significantly suppressed hepatocellular carcinoma proliferation and metastasis in mice models.PMID:37524271 | DOI:10.1016/j.ejps.2023.106549
Source: European Journal of Pharmaceutical Sciences - July 31, 2023 Category: Drugs & Pharmacology Authors: Jie Li Lijuan Zhang Yun Tao Zongqiong Sun Yuxi Ge Shudong Hu Source Type: research
