Filtered By:
Specialty: Genetics & Stem Cells
Cancer: Adenocarcinoma

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 23 results found since Jan 2013.

Genetic Regulation of Liver Metabolites and Transcripts Linking to Biochemical-Clinical Parameters
Conclusion In summary, this study is the first to combine metabolomics, transcriptomics, and genome-wide association studies in a porcine model. Our results improve understanding of the genetic regulation of metabolites which link to transcripts and finally biochemical-clinical parameters. Further, high-performance profiling of metabolites as intermediate phenotypes is a potentially powerful approach to uncover how genetic variation affects metabolic and health status. Our results advance knowledge in areas of biomedical and agricultural interest and identify potential correlates of biomarkers, SNPs-metabolites, SNPs-tran...
Source: Frontiers in Genetics - April 16, 2019 Category: Genetics & Stem Cells Source Type: research

Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer.
CONCLUSIONS: Our findings support the role of MIF in tumor aggressiveness and suggest its potential application as a therapeutic target for gallbladder cancer. PMID: 26530123 [PubMed - in process]
Source: Genomics Proteomics ... - November 6, 2015 Category: Genetics & Stem Cells Authors: Subbannayya T, Leal-Rojas P, Barbhuiya MA, Raja R, Renuse S, Sathe G, Pinto SM, Syed N, Nanjappa V, Patil AH, Garcia P, Sahasrabuddhe NA, Nair B, Guerrero-Preston R, Navani S, Tiwari PK, Santosh V, Sidransky D, Prasad TS, Gowda H, Roa JC, Pandey A, Chatte Tags: BMC Cancer Source Type: research

Role of ATM in bystander signaling between human monocytes and lung adenocarcinoma cells
Publication date: December 2015 Source:Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 794 Author(s): Somnath Ghosh, Anu Ghosh, Malini Krishna The response of a cell or tissue to ionizing radiation is mediated by direct damage to cellular components and indirect damage mediated by radiolysis of water. Radiation affects both irradiated cells and the surrounding cells and tissues. The radiation-induced bystander effect is defined by the presence of biological effects in cells that were not themselves in the field of irradiation. To establish the contribution of the bystander effect in the surv...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 11, 2015 Category: Genetics & Stem Cells Source Type: research

Deregulation of a Cis-Acting lncRNA in Non-small Cell Lung Cancer May Control HMGA1 Expression
ConclusionOur results suggest that HMGA1-lnc is a novel cis-acting lncRNA that negatively regulates HMGA1 gene expression in lung cells. Further characterization of this regulatory mechanism may advance our understanding of the maintenance of lung cancer phenotypes and uncover a novel therapeutic intervention point for tumors driven by HMGA1.
Source: Frontiers in Genetics - January 11, 2021 Category: Genetics & Stem Cells Source Type: research

GSE61214 Identification of DEK as a potential therapeutic target for Neuroendocrine prostate cancer
Conclusions: The results suggest that DEK may play an important role in the progression of prostate cancer, especially NEPC and provide a potential biomarker to aid risk stratification of prostate cancer and a novel therapeutic target for treating NEPC.
Source: GEO: Gene Expression Omnibus - January 15, 2015 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE93290 Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines (A-498, 786-O, A549, TE-8, PANC-1, SW1990, PC3 and PC3M)
Contributors : Naohiko Seki ; Takayuki AraiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines ( renal cell carcinoma, lung adenocarcinoma, esophageal, pancreatic and prostate cancer) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - January 8, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE93677 Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma
Contributors : Haibo Sun ; De-Chen Lin ; Qi Cao ; Brenden Pang ; David-Hayon Gae ; Victor K Lee ; Huey J Lim ; Ngan Doan ; Jonathan W Said ; Sigal Gery ; Anand Mayakonda ; Charles Forscher ; Jeffery W Tyner ; Phillip H KoefflerSeries Type : Expression profiling by arrayOrganism : Homo sapiensEwing Sarcoma (EWS) is a devastating soft tissue sarcoma affecting predominantly young individuals. Tyrosine kinases (TKs) and associated pathways are continuously activated in many malignancies including EWS; these enzymes provide candidate therapeutic targets. Using two high-throughput screens with EWS cell lines (a siRNA library and...
Source: GEO: Gene Expression Omnibus - January 18, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Genes, Vol. 9, Pages 16: SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma
g Zhicheng Gong There is increasing evidence for the contribution of synuclein alpha (SNCA) to the etiology of neurological disorders, such as Parkinson’s disease (PD). However, little is known about the detailed role of SNCA in human cancers, especially lung cancers. Here, we evaluated the effects of SNCA on the occurrence and prognosis of lung adenocarcinoma (ADC). Comprehensive bioinformatics analyses of data obtained from the Oncomine platform, the human protein atlas (HPA) project and the cancer cell line encyclopedia (CCLE) demonstrated that SNCA expression was significantly reduced in both ADC tissues and ca...
Source: Genes - January 4, 2018 Category: Genetics & Stem Cells Authors: Yuanliang Yan Zhijie Xu Xiaofang Hu Long Qian Zhi Li Yangying Zhou Shuang Dai Shuangshuang Zeng Zhicheng Gong Tags: Article Source Type: research

Up-regulation of C5orf34 promotes lung adenocarcinoma migration and is correlated with worse prognosis.
CONCLUSION: Our results firstly revealed that C5orf34 might play a facilitating role in LAD development and progression by regulating MAPK signaling pathway. Furthermore, our data implied that C5orf34 may be a potential predictor and treatment target for LAD. PMID: 30771479 [PubMed - as supplied by publisher]
Source: Gene - February 13, 2019 Category: Genetics & Stem Cells Authors: He D, Wu Z, He J, Wang Y, Li Z, Gao S Tags: Gene Source Type: research

Genes, Vol. 10, Pages 921: Wnt-11 Expression Promotes Invasiveness and Correlates with Survival in Human Pancreatic Ductal Adeno Carcinoma
ysal-Onganer Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms of cancer, proving difficult to manage clinically. Wnt-11, a developmentally regulated gene producing a secreted protein, has been associated with various carcinomas but has not previously been studied in PDAC. The present study aimed to elucidate these aspects first in vitro and then in a clinical setting in vivo. Molecular analyses of Wnt-11 expression as well as other biomarkers involved qRT-PCR, RNA-seq and siRNA. Proliferation was measured by MTT; invasiveness was quantified by Boyden chamber (Matrigel) assay. Wnt-11 mRNA was presen...
Source: Genes - November 10, 2019 Category: Genetics & Stem Cells Authors: Dart Arisan Owen Hao Jiang Uysal-Onganer Tags: Article Source Type: research

GSE132813 Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in esophageal adenocarcinoma
Contributors : Jian Pan ; Tiago C Silva ; Nicole Gull ; Qian Yang ; Jasmine Plummer ; Stephanie Chen ; Kenji Daigo ; Takao Hamakubo ; Ling-Wen Ding ; Samuel J Klempner ; Benjamin P Berman ; H P Koeffler ; De-Chen LinSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensWe profiled fresh-frozen esophageal tumor and normal samples and cell lines with chromatin immunoprecipitation sequencing (ChIP-Seq). Mathematically modeling was performed to establish (super)-enhancers landscapes and inter-connected transcriptional ci...
Source: GEO: Gene Expression Omnibus - June 14, 2020 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research

GSE167590 SOX9 modulates cancer biomarker and cilia genes in pancreatic cancer
We report 93 differentially expressed (DE) genes, with convergence on alterations to Notch-signaling pathways and ciliogenesis. These results point to SOX9 and Notch activity being in a positive feedback loop; and, SOX9 regulating cilia production in PDAC. We additionally performed ChIP-seq in PANC-1 cells to identify direct targets of SOX9 binding and integrated these results with our DE gene list. Nine of the top ten downregulated genes have evidence of direct SOX9 binding at their promoter regions.  One of these targets was the cancer stem cell marker EpCAM. Using whole-mount in situ hybridization to detect epcam ...
Source: GEO: Gene Expression Omnibus - February 27, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

GSE164921 Global transcriptomic changes in alveolar epithelial type II (ATII) cells upon GRK6 depletion based on RNA-seq
Contributors : Y Zhou ; L Yao ; S Yao ; Y WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensG protein coupled receptor kinase 6 (GRK6) is a member of the GRKs family, which is expressed in various tissues and involved in the development of several diseases, including lung adenocarcinoma. Our previous study suggested that GRK6 expression was significantly down-regulated in lung adenocarcinoma patients, and its level was an independent prognostic factor for overall survival. Here, by performing RNA-sequencing (RNA-seq) in alveolar epithelial type II (ATII) cells transfected with eithe...
Source: GEO: Gene Expression Omnibus - April 24, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE173433 Single-cell RNA-seq following APE1/Ref-1 knockdown in Pancreatic Ductal Adenocarcinoma
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAPE1 was knocked down using siRNA in low passage patient-derived PDAC cells and the resulting cells, along with control cells were analysed using scRNA-seq to identify differentially expressed genes and pathways as a result of APE1 knock-down.
Source: GEO: Gene Expression Omnibus - April 28, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

KRT18 Modulates Alternative Splicing of Genes Involved in Proliferation and Apoptosis Processes in Both Gastric Cancer Cells and Clinical Samples
Keratin 18 (KRT18), one of the most abundant keratins in epithelial and endothelial cells, has been reported to be aberrantly expressed in many malignancies and extensively regarded as a biomarker and important regulator in multiple cancers, including gastric cancer (GC). But the molecular regulatory mechanisms of KRT18 in GC patients and cells are largely unknown. In the present study, we analyzed the expression level of KRT18 in 450 stomach adenocarcinoma tissue samples from TCGA database and found a significantly higher expression level in tumor tissues. We then explored the potential functions of KRT18 in AGS cells (hu...
Source: Frontiers in Genetics - July 5, 2021 Category: Genetics & Stem Cells Source Type: research