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Specialty: Pathology
Cancer: Adenocarcinoma

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Total 22 results found since Jan 2013.

Long non-coding RNA MALAT1 aggravates human retinoblastoma by sponging miR-20b-5p to upregulate STAT3.
CONCLUSION: MALAT1 could increase proliferation and reduce apoptosis by sponging miR-20b-5p to upregulate STAT3 in RB cells. Therefore, MALAT1 might be a latent target in the RB treatment. PMID: 32336590 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - April 17, 2020 Category: Pathology Authors: Wang L, Zhang Y, Xin X Tags: Pathol Res Pract Source Type: research

Downregulation of FOXP3 inhibits cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma
Publication date: Available online 8 September 2017 Source:Pathology - Research and Practice Author(s): Chun Li, Liwei Sun, Rui Jiang, Peng Wang, Haogang Xue, Yudong Zhan, Xiaodong Gai Our study aimed to investigate the biological role of FOXP3 expression in human lung adenocarcinoma (LAD) tissues and evaluate its involvement in cell proliferation and chemosensitivity to cisplatin in LAD cells. Paraffin-embedded tissues from 50 LAD patients were collected to detect FOXP3 and Ki-67 expression using immunohistochemistry (IHC). Downregulation of FOXP3 in A549 cells was performed using siRNA transfection. Real-time PCR or wes...
Source: Pathology Research and Practice - September 9, 2017 Category: Pathology Source Type: research

Downregulation of FOXP3 inhibits cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma.
Abstract Our study aimed to investigate the biological role of FOXP3 expression in human lung adenocarcinoma (LAD) tissues and evaluate its involvement in cell proliferation and chemosensitivity to cisplatin in LAD cells. Paraffin-embedded tissues from 50 LAD patients were collected to detect FOXP3 and Ki-67 expression using immunohistochemistry (IHC). Downregulation of FOXP3 in A549 cells was performed using siRNA transfection. Real-time PCR or western blot assay was performed to analyze FOXP3 expression in A549 cells. Cell proliferation and cisplatin cytotoxicity test were assessed by CCK-8 assay. The expression...
Source: Pathology, Research and Practice - September 8, 2017 Category: Pathology Authors: Li C, Sun L, Jiang R, Wang P, Xue H, Zhan Y, Gai X Tags: Pathol Res Pract Source Type: research

CIP2A is overexpressed in human endometrioid adenocarcinoma and regulates cell proliferation,invasion and apoptosis
Conclusions CIP2A is overexpressed in endometrioid adenocarcinoma and CIP2A promotes the malignant growth and invasion,decrease apoptosis in entometrioid adenocarcinoma cell lines. These results validate that CIP2A plays an important role in the carcinogenesis of endometrioid adenocarcinoma and establishes CIP2A as a clinically relevant oncoprotein and may presents a promising therapeutic target for cancer treatment.
Source: Pathology Research and Practice - November 19, 2017 Category: Pathology Source Type: research

CIP2A is overexpressed in human endometrioid adenocarcinoma and regulates cell proliferation, invasion and apoptosis
Conclusions CIP2A is overexpressed in endometrioid adenocarcinoma and CIP2A promotes the malignant growth and invasion,decrease apoptosis in entometrioid adenocarcinoma cell lines. These results validate that CIP2A plays an important role in the carcinogenesis of endometrioid adenocarcinoma and establishes CIP2A as a clinically relevant oncoprotein and may presents a promising therapeutic target for cancer treatment.
Source: Pathology Research and Practice - December 22, 2017 Category: Pathology Source Type: research

Tumor-Promoting Activity of Long Noncoding RNA LINC00466 in Lung Adenocarcinoma via miR-144 –Regulated HOXA10 Axis
Previous investigations have implicated long noncoding RNAs in lung adenocarcinoma, which is an aggressive disease with poor prognosis and high mortality. Through the alteration of lung adenocarcinoma –related long noncoding RNA and miRNA based on microarray analysis, our aim was to understand the role of LINC00466 and miR-144 in lung adenocarcinoma progression. The relationship among LINC00466, miR-144, and HOXA10 was also verified. Moreover, to examine whether the LINC00466/miR-144/HOXA10 axi s contributed to the cellular processes in lung adenocarcinoma, A549 and XWLC-05 cells were transduced with siRNA LINC00466, siR...
Source: American Journal of Pathology - August 1, 2019 Category: Pathology Authors: Tiangang Ma, Yanbing Hu, Yingxue Guo, Bingdi Yan Source Type: research

Expression of kinesin family member C1 in pancreatic ductal adenocarcinoma affects tumor progression and stemness
This study aimed to analyze the expression and biological function of KIFC1 in PDAC. Immunohistochemically, KIFC1 was found in 37 of 81 PDAC cases (46%). A high expression of KIFC1 was significantly related to tumor size (p = 0.023) and poor overall survival (p = 0.011). Univariate and multivariate analysis indicated that KIFC1 expression was a prognostic factor in PDAC cases. As for cancer stem cell markers, KIFC1 expression tended to co-express significantly with CD44 (p < 0.01). The growth and spheroid colony formation of KIFC1 small interfering RNA (siRNA)-transfected PDAC cells were significantly lower than those o...
Source: Pathology, Research and Practice - December 24, 2022 Category: Pathology Authors: Akira Ishikawa Hiroki Fujii Takafumi Fukui Aya Kido Narutaka Katsuya Kazuhiro Sentani Kazuya Kuraoka Sho Tazuma Takeshi Sudo Masahiro Serikawa Shiro Oka Naohide Oue Source Type: research

PPAPDC1B and WHSC1L1 Are Common Drivers of the 8p11-12 Amplicon, Not Only in Breast Tumors But also in Pancreatic Adenocarcinomas and Lung Tumors.
Abstract Amplification of the 8p11-12 chromosomal region is a common genetic event in many epithelial cancers. In breast cancer, several genes within this region have been shown to display oncogenic activity. Among these genes, the enzyme-encoding genes, PPAPDC1B and WHSC1L1, have been identified as potential therapeutic targets. We investigated whether PPAPDC1B and WHSC1L1 acted as general driver genes, thereby serving as therapeutic targets in other tumors with 8p11-12 amplification. By using publicly available genomic data from a panel of 883 cell lines derived from different cancers, we identified the cell lin...
Source: The American Journal of Pathology - September 16, 2013 Category: Pathology Authors: Mahmood SF, Gruel N, Nicolle R, Chapeaublanc E, Delattre O, Radvanyi F, Bernard-Pierrot I Tags: Am J Pathol Source Type: research

HOPX is methylated and exerts tumour suppressive function through Ras‐induced senescence in human lung cancer
Abstract HOPX acts as tumour suppressor in various cancers. However the regulation of HOPX in human lung cancer as well as the mechanism underlying its tumour suppressive function has not yet been well elucidated. Here we investigated the epigenetic regulation and molecular mechanism by which HOPX exerts growth inhibitory effects. We found that HOPX was downregulated in 12 out of 13 lung cancer cell lines and in 69 out of 120 primary lung tumours at mRNA and protein levels. Patients with lung adenocarcinoma (ADC) exhibited significantly more positive staining of HOPX protein compared with lung squamous cell carcinoma (SCC)...
Source: The Journal of Pathology - October 24, 2014 Category: Pathology Authors: Yuan Chen, Linlin Yang, Tiantian Cui, Manuela Pacyna‐Gengelbach, Iver Petersen Tags: Original Article Source Type: research

Long Noncoding RNAs as Putative Biomarkers for Prostate Cancer Detection
Publication date: November 2014 Source:The Journal of Molecular Diagnostics, Volume 16, Issue 6 Author(s): Bongyong Lee , Joseph Mazar , Muhammad N. Aftab , Feng Qi , John Shelley , Jian-Liang Li , Subramaniam Govindarajan , Felipe Valerio , Inoel Rivera , Tadzia Thurn , Tien Anh Tran , Darian Kameh , Vipul Patel , Ranjan J. Perera Prostate cancer is one of the leading causes of mortality among US males. There is an urgent unmet need to develop sensitive and specific biomarkers for the early detection of prostate cancer to reduce overtreatment and accompanying morbidity. We identified a group of differentially expressed ...
Source: The Journal of Molecular Diagnostics - December 5, 2014 Category: Pathology Source Type: research

HOPX is methylated and exerts tumour‐suppressive function through Ras‐induced senescence in human lung cancer
Abstract HOPX acts as a tumour suppressor in various cancers. However, the regulation of HOPX in human lung cancer as well as the mechanism underlying its tumour‐suppressive function has not yet been well elucidated. Here we investigated the epigenetic regulation and molecular mechanism by which HOPX exerts growth inhibitory effects. We found that HOPX was down‐regulated in 12 out of 13 lung cancer cell lines and in 69 out of 120 primary lung tumours at mRNA and protein levels. Patients with lung adenocarcinoma (ADC) exhibited significantly more positive staining of HOPX protein compared with lung squamous cell carcino...
Source: The Journal of Pathology - December 18, 2014 Category: Pathology Authors: Yuan Chen, Linlin Yang, Tiantian Cui, Manuela Pacyna‐Gengelbach, Iver Petersen Tags: Original Paper Source Type: research

Binding of the mAb RP215 to IgG in metastatic lung adenocarcinomas is correlated with poor prognosis
ConclusionsRP215 staining is strongly correlated with differentiation, local invasion, metastasis, and clinical outcome of patients with lung ADC. Our results suggest that RP215 can serve as a biomarker for prognosis of lung ADC.This article is protected by copyright. All rights reserved.
Source: Histopathology - March 1, 2015 Category: Pathology Authors: Yang Liu, Dan Liu, Chong Wang, Qinyuan Liao, Jing Huang, Dongyang Jiang, Wenwei Shao, Cheng Cameron Yin, Youhui Zhang, Gregory Lee, Xiaoyan Qiu Tags: Original Article Source Type: research

Binding of the monoclonal antibody RP215 to immunoglobulin G in metastatic lung adenocarcinomas is correlated with poor prognosis
ConclusionsRP215 staining is correlated strongly with differentiation, local invasion, metastasis and clinical outcome of patients with lung ADC. Our results suggest that RP215 can serve as a biomarker for prognosis of lung ADC.
Source: Histopathology - April 30, 2015 Category: Pathology Authors: Yang Liu, Dan Liu, Chong Wang, Qinyuan Liao, Jing Huang, Dongyang Jiang, Wenwei Shao, Cheng Cameron Yin, Youhui Zhang, Gregory Lee, Xiaoyan Qiu Tags: Original Article Source Type: research

Insulinoma-Associated Protein 1 Is a Crucial Regulator of Neuroendocrine Differentiation in Lung Cancer.
Abstract Insulinoma-associated protein 1 (INSM1) is expressed exclusively in embryonic developing neuroendocrine (NE) tissues. INSM1 gene expression is specific for small-cell lung cancer (SCLC), along with achaete-scute homolog-like 1 (ASCL1) and several NE molecules, such as chromogranin A, synaptophysin, and neural cell adhesion molecule 1. However, the underlying biological role of INSM1 in lung cancer remains largely unknown. We first showed that surgically resected SCLC samples specifically expressed INSM1. Forced expression of the INSM1 gene in adenocarcinoma cell lines (H358 and H1975) induced the expressi...
Source: The American Journal of Pathology - October 16, 2015 Category: Pathology Authors: Fujino K, Motooka Y, Hassan WA, Ali Abdalla MO, Sato Y, Kudoh S, Hasegawa K, Niimori-Kita K, Kobayashi H, Kubota I, Wakimoto J, Suzuki M, Ito T Tags: Am J Pathol Source Type: research

Forkhead box protein A2, a pioneer factor for hepatogenesis, is involved in the expression of hepatic phenotype of alpha-fetoprotein-producing adenocarcinoma
Publication date: Available online 23 July 2017 Source:Pathology - Research and Practice Author(s): Nobuhisa Yamamura, Kazunori Fugo, Takashi Kishimoto Alpha-fetoprotein (AFP)-producing adenocarcinoma is a high-malignant variant of adenocarcinoma with a hepatic or fetal-intestinal phenotype. The number of cases of AFP-producing adenocarcinomas is increasing, but the molecular mechanism underlying the aberrant production of AFP is unclear. Here we sought to assess the role of Forkhead box A (FoxA)2, which is a pioneer transcription factor in the differentiation of hepatoblasts. FoxA2 expression was investigated in five cas...
Source: Pathology Research and Practice - July 24, 2017 Category: Pathology Source Type: research