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Long non-coding RNA Plasmacytoma variant 1 in acute ischemic stroke: association with disease risk, severity, and recurrence-free survival and relation with inflammatory cytokines
CONCLUSION: Lnc-PVT1 not only correlates with AIS risk, inflammation, and disease severity, but also reveals a dependable value for AIS prognostication, which still needs further studies for validation.PMID:34617244 | DOI:10.1007/s11845-021-02724-x
Source: Methods of Information in Medicine - October 7, 2021 Category: Information Technology Authors: Liqiang Yu Weihua Ling Qi Fang Source Type: research

Depleting SOX2 improves ischemic stroke via lncRNA PVT1/microRNA-24-3p/STAT3 axis
CONCLUSION: This study presents that depleting SOX2 improves IS via PVT1/miR-24-3p/STAT3 axis which may broaden our knowledge about the mechanisms of SOX2/PVT1/miR-24-3p/STAT3 axis and provide a reference of therapy for IS.PMID:34521353 | DOI:10.1186/s10020-021-00346-8
Source: Molecular Medicine - September 15, 2021 Category: Molecular Biology Authors: Zhongjun Chen Tieping Fan Xusheng Zhao Zhichen Zhang Source Type: research

Long Non-coding RNA PVT1 Inhibits miR-30c-5p to Upregulate Rock2 to Modulate Cerebral Ischemia/Reperfusion Injury Through MAPK Signaling Pathway Activation
AbstractLong non-coding RNAs (lncRNAs) play a key role in a variety of disease processes. Plasmacytoma variant translocation 1 (PVT1), a lncRNA, is known to regulate cell functions and play a key role in the pathogenesis of many malignant tumors. The function and molecular mechanisms of lncRNA-PVT1 in cerebral ischemia remain unknown. Real-time PCR (qRT-PCR) was used to detect lncRNA-PVT1 and microRNA-30c-5p (miR-30c-5p) expression in the brain tissues of mice underwent middle cerebral artery occlusion/reperfusion (MCAO/R) and oxygen –glucose deprivation/reperfusion (OGD/R)-treated mouse primary brain neurons. Gain- or l...
Source: Molecular Neurobiology - August 26, 2021 Category: Neurology Source Type: research

Recurrent stroke due to quasi-moyamoya disease associated with POEMS syndrome: An autopsy case
POEMS syndrome, an acronym for polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes, is a fatal disorder associated with plasmacytoma and overproduction of vascular endothelial growth factor (VEGF) [1,2]. Nowadays, a new diagnostic criteria is proposed with high sensitivity and specificity: it demands both three mandatory major criteria (polyneuropathy, monoclonal plasma cell proliferative disorder and elevated VEGF) and at least two of the four minor criteria (oedema/effusion, skin changes, organomegaly and sclerotic bone lesions) [2].
Source: Journal of the Neurological Sciences - February 14, 2020 Category: Neurology Authors: Teruhiko Sekiguchi, Satoru Ishibashi, Jo Sasame, Jun-Ichi Mukae, Kotaro Noda, Hiroaki Tanaka, Koh Yamamoto, Yasunori Takemoto, Jiro Kumagai, Takanori Yokota Tags: Letter to the Editor Source Type: research