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Total 40 results found since Jan 2013.
"Don't let it to air": A cautionary tale of the potential consequences of surgery of residual cancer
Brain Behav Immun. 2023 Apr 29:S0889-1591(23)00110-1. doi: 10.1016/j.bbi.2023.04.012. Online ahead of print.ABSTRACTIn this issue of the BBI, Haldar et al. demonstrate that major surgical stress from laparotomy caused a significant increase in post-operative metastatic burden in a mouse model of cancer. They identified this metastatic outbreak was driven by a novel mechanism of direct, surgery-induced activation of the primary tumour which, if left in situ, released pro-metastatic factors (IL-6, IL-8, and VEGF). Surgical stress induced significant changes in the transcriptional programming of the primary tumor, with marked...
Source: Brain, Behavior, and Immunity - May 1, 2023 Category: Neurology Authors: Gayashan Tennakoon Rebecca Auer Source Type: research
Perioperative escape from dormancy of spontaneous micro-metastases: A role for malignant secretion of IL-6, IL-8, and VEGF, through adrenergic and prostaglandin signaling
Brain Behav Immun. 2023 Jan 13:S0889-1591(23)00005-3. doi: 10.1016/j.bbi.2023.01.005. Online ahead of print.ABSTRACTWe recently showed that a minimally-invasive removal of MDA-MB-231HM primary tumors (PTs) and elimination of their secreted factors (including IL-6, IL-8, VEGF, EGF, PDGF-aa, MIF, SerpinE1, and M-CSF), caused regression of spontaneous micro-metastases into a non-growing dormant state. To explore the underlying mechanisms and potential clinical ramifications of this phenomenon, we herein used the MDA-MB-231HM human breast cancer cell-line, in-vitro, and in vivo following orthotopic implantation in immune-defic...
Source: Brain, Behavior, and Immunity - January 16, 2023 Category: Neurology Authors: Rita Haldar Lee Shaashua Berger Ella Rossenne Arielle Radin Anabel Eckerling Elad Sandbank Erica K Sloan Steve W Cole Shamgar Ben-Eliyahu Source Type: research
Mucormycosis threats: A systemic review
J Basic Microbiol. 2022 Nov 4. doi: 10.1002/jobm.202200334. Online ahead of print.ABSTRACTDuring the catastrophic wave of Coronavirus disease 2019, health agencies started to report an infrequent but lethal mucormycosis or black fungal infection. Primarily, it causes sinusitis by affecting nasal, oral, lung, brain, ocular, and other body tissues. It becomes more fatal, especially in diabetic, cancer, and immune-compromised patients. Before 2020, the prevalence of mucormycosis was very rare but it has rapidly emerged globally from late 2020 to mid-2021. Recently, the mucormycosis got worse and epidemic with more than 30,000...
Source: Cancer Control - November 4, 2022 Category: Cancer & Oncology Authors: Shaurya Prakash Antresh Kumar Source Type: research
Postoperative surveillance in cranial and spinal tumor neurosurgery: when is this warranted?
CONCLUSIONS: Postoperative surveillance in cranial and spinal tumor neurosurgery might only be required in a distinct patient collective. In this study, the authors present a new score allowing efficient prediction of the likelihood of early adverse events in patients undergoing neurooncological procedures, thus helping to stratify the necessity for ICU or intermediate care unit beds. Nevertheless, validation of the score in a multicenter prospective setting is needed.PMID:36115051 | DOI:10.3171/2022.7.JNS22691
Source: Journal of Neurosurgery - September 17, 2022 Category: Neurosurgery Authors: Stephanie Schipmann Dorothee C äcilia Spille Marco Gallus Sebastian Lohmann Michael Schwake Nils Warneke Eric Suero Molina Walter Stummer Markus Holling Source Type: research
Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research
