• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Potential Applications of Remote Limb Ischemic Conditioning for Chronic Cerebral Circulation Insufficiency
Conclusion Due to its long-term and often invisible course, CCCI has received less attention than acute cerebral ischemic stroke. However, without appropriate intervention, CCCI may lead to a variety of adverse events. Because the pathophysiological changes associated with CCCI are complex, pharmacological research in this area has been disappointing. Recent research suggests that RLIC, which is less invasive and more well-tolerated than drug treatment, can activate endogenous protective mechanisms during CCCI. In the present report, we reviewed studies related to CCCI (Table 1), as well as those related to stroke and sta...
Source: Frontiers in Neurology - May 2, 2019 Category: Neurology Source Type: research

Functional MRI of Letter Cancellation Task Performance in Older Adults
Conclusion The present work is the first to identify neural correlates of the LCT using fMRI and tablet technology in a healthy aging population. Across all ages, the activation was found to be bilateral, including in the cerebellum, superior temporal lobe, precentral gyrus, frontal gyrus, and various occipital and parietal areas. With increasing age, performance generally decreased and brain activity was reduced in the supplementary motor area, middle and inferior frontal gyrus, middle occipital gyrus, putamen and cerebellum. Better LCT performance was correlated with increased activity in the middle frontal gyrus, and r...
Source: Frontiers in Human Neuroscience - April 15, 2019 Category: Neuroscience Source Type: research

Abstract 4058: Acid-sensing ion channel 1a (ASIC1a) contributes to cell proliferation and migration caused by acidic environment in human glioma cells
Conclusions: Extracellular acid reduces proliferation and migration in glioma cells. Extracellular acid induces death of glioma cells via ASIC1a mechanisms. These results indicate the presence of ASIC1a in glioma cells and may play significant role in glioma progression. This work was supported by the National Institutes of Health grant numbers NIH R01NS047506, R01NS066027, UL1 RR025008, U54 RR026137, AHA 0840132N, and ALZ IIRG-10-173350. Citation Format: Mingli Liu, Alyssa (Aihui) Guo, Christopher Ghiathi, Zhigang Xiong. Acid-sensing ion channel 1a (ASIC1a) contributes to cell proliferation and migration caused by acidic ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Liu, M., Guo, A., Ghiathi, C., Xiong, Z. Tags: Tumor Biology Source Type: research