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Transcriptomic Analysis of Mecp2 Mutant Mice Reveals Differentially Expressed Genes and Altered Mechanisms in Both Blood and Brain
This study was carried out in accordance with the recommendations of National Animal Welfare Authority, Ireland. The protocol was approved by the Animal Ethical Committee Trinity College Dublin and HPRA.Author ContributionsAS performed the experiments and wrote the paper; KH provided assistance in the design and analysis of the RNAseq experiment; DT contributed to sample extraction and establishment of the colony; and DT and MG designed and supervised all the parts of the research and the writing of the manuscript.FundingThe study was funded by the Wellcome Trust Grant WT079408/C/06/Z issued to MG, and by an SFI FN Funded ...
Source: Frontiers in Psychiatry - April 29, 2019 Category: Psychiatry Source Type: research

Neurologic Outcome Predictors in Pediatric Intracerebral Hemorrhage Brief Report
Background and Purpose—Intracerebral hemorrhage is a considerable source of morbidity and mortality. This 3-center study describes outcomes of pediatric intracerebral hemorrhage and identifies 2-year neurological outcome predictors.Methods—Children 29 days to 18 years of age presenting with intracerebral hemorrhage from March 2007 to May 2015 were enrolled prospectively. Exclusion criteria included trauma; intracranial tumor; hemorrhagic transformation of arterial ischemic stroke or cerebral sinovenous thrombosis; isolated subdural, epidural, or subarachnoid hemorrhage; and abnormal baseline neurological function. Intr...
Source: Stroke - June 25, 2018 Category: Neurology Authors: Giulia S. Porcari, Lauren A. Beslow, Rebecca N. Ichord, Daniel J. Licht, Jonathan T. Kleinman, Lori C. Jordan Tags: Pediatrics, Prognosis, Mortality/Survival, Intracranial Hemorrhage Brief Reports Source Type: research

Cardiac myxoma: clinical characteristics, surgical intervention, intra-operative challenges and outcome.
CONCLUSION: The success rate after surgical removal of cardiac myxoma in this study was substantial and complications were rare. PMID: 28762298 [PubMed - as supplied by publisher]
Source: Perfusion - July 1, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Abu Abeeleh M, Saleh S, Alhaddad E, Alsmady M, Alshehabat M, Bani Ismail Z, Massad I, Bani Hani A, Abu Halaweh S Tags: Perfusion Source Type: research

Neuropsychiatric disorders among Syrian and Iraqi refugees in Jordan, 2012-2013: A retrospective, cohort study (P2.324)
CONCLUSIONS:There is a need for long-term planning and financing for neuropsychiatric disorders traditionally considered outside of refugee health. Possible interventions may include stroke risk factor reduction and targeted medication donations for multiple sclerosis, epilepsy, and schizophrenia. Study Supported by: No funding recieved.Disclosure: Dr. McKenzie has nothing to disclose. Dr. Spiegel has nothing to disclose. Dr. Khalifa has nothing to disclose. Dr. Mateen has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: McKenzie, E., Spiegel, P., Khalifa, A., Mateen, F. Tags: Global Neurology Source Type: research

Neuropsychiatric disorders among Syrian and Iraqi refugees in Jordan: a retrospective cohort study 2012–2013
Conclusions: Neuropsychiatric disorders, including those traditionally considered outside the purview of refugee health, are an important burden to health among Iraqi and Syrian refugees. Possible interventions could include stroke risk factor reduction and targeted medication donations for multiple sclerosis, epilepsy, and schizophrenia.
Source: Conflict and Health - March 29, 2015 Category: Global & Universal Authors: Erica McKenziePaul SpiegelAdam KhalifaFarrah Mateen Source Type: research