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Total 26098 results found since Jan 2013.

Neurofibromatosis type 1-associated optic pathway gliomas: pathogenesis and emerging treatments
Eur Rev Med Pharmacol Sci. 2023 Jun;27(12):5636-5653. doi: 10.26355/eurrev_202306_32804.ABSTRACTNeurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder associated with an increased risk of developing a variety of benign and malignant tumors. Fifteen to 20% of children with NF1 are diagnosed with an optic pathway glioma (NF1-OPG) before 7 years of age, and more than half of them experience visual decline. At present, no effective therapy is available for prevention, restoration, or even stabilization of vision loss in subjects affected by NF1-OPG. This paper aims to review the main emerging pharmacological ...
Source: European Review for Medical and Pharmacological Sciences - July 4, 2023 Category: Drugs & Pharmacology Authors: A Amato B P Imbimbo B Falsini Source Type: research

Impact of Continuing First-Line EGFR Tyrosine Kinase Inhibitor Therapy Beyond RECIST Disease Progression in Patients with Advanced EGFR-Mutated Non-Small-Cell Lung Cancer (NSCLC): Retrospective GFPC 04-13 Study
This study suggests that under certain circumstances, first-line TKI treatment continuation after RECIST progression is an acceptable option in EGFR-mutated NSCLC patients. Clinical trial information: NCT02293733
Source: Targeted Oncology - August 29, 2015 Category: Cancer & Oncology Source Type: research

Diagnosis of Brain Metastases from Lung Cancer Using a Modified Electromagnetism like Mechanism Algorithm
Abstract Brain metastases are commonly found in patients that are diagnosed with primary malignancy on their lung. Lung cancer patients with brain metastasis tend to have a poor survivability, which is less than 6 months in median. Therefore, an early and effective detection system for such disease is needed to help prolong the patients’ survivability and improved their quality of life. A modified electromagnetism-like mechanism (EM) algorithm, MEM-SVM, is proposed by combining EM algorithm with support vector machine (SVM) as the classifier and opposite sign test (OST) as the local search technique. The propo...
Source: Journal of Medical Systems - November 14, 2015 Category: Information Technology Source Type: research

Weekly Postings
See something of interest? Please share our postings with colleagues in your institutions! Spotlight The University of Pittsburgh Health Sciences Library System (HSLS) invites applications for the newly created position of All of Us Community Engagement Coordinator for the Middle Atlantic Region of the National Network of Libraries of Medicine (NNLM MAR). View the full posting for more information about the position. Renew your membership today! If you have not yet verified that your organization’s record is up-to-date, see our recent blog post about the benefits of renewal and NNLM Membership. Are you having trouble...
Source: NN/LM Middle Atlantic Region Blog - October 6, 2017 Category: Databases & Libraries Authors: Hannah Sinemus Tags: Weekly Postings Source Type: news

Negative Symptom Dimensions of the Positive and Negative Syndrome Scale Across Geographical Regions: Implications for Social, Linguistic, and Cultural Consistency
Conclusion: These results suggest that the Positive and Negative Syndrome Scale negative symptom factor can be better represented by a two-factor model than by a single-factor model. Additionally, the results show significant differences in responses to items representing the Positive and Negative Syndrome Scale expressive factors, but not the experiential factors, across regions. This could be due to a lack of equivalence between the original and translated versions, cultural differences with the interpretation of items, dissimilarities in rater training, or diversity in the understanding of scoring anchors. Knowing which...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Original Research experiential deficits expressive deficits negative symptoms PANSS Positive and Negative Syndrome Scale schizophrenia Source Type: research

Genes, Vol. 12, Pages 1037: ZEB2, the Mowat-Wilson Syndrome Transcription Factor: Confirmations, Novel Functions, and Continuing Surprises
onidi After its publication in 1999 as a DNA-binding and SMAD-binding transcription factor (TF) that co-determines cell fate in amphibian embryos, ZEB2 was from 2003 studied by embryologists mainly by documenting the consequences of conditional, cell-type specific Zeb2 knockout (cKO) in mice. In between, it was further identified as causal gene causing Mowat-Wilson Syndrome (MOWS) and novel regulator of epithelial–mesenchymal transition (EMT). ZEB2’s functions and action mechanisms in mouse embryos were first addressed in its main sites of expression, with focus on those that helped to explain neurodevelopmental an...
Source: Genes - July 3, 2021 Category: Genetics & Stem Cells Authors: Judith C. Birkhoff Danny Huylebroeck Andrea Conidi Tags: Review Source Type: research

Does Long COVID Exist in the Pediatric Age Group?
Discussion With COVID-19, the scientific research process is playing out daily in the press where the general public can see for themselves and share in the new knowledge and frustrating events that occur usually behind the curtain of science. People try to understand the little snippets of new knowledge that come forth and how they fit into the COVID problem, and most importantly how it may affect themselves, the people they care about and their community. Patients and families daily ask questions of their health care providers who themselves have the same questions, and answer something like “We’re learning s...
Source: PediatricEducation.org - November 29, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

A small but real risk of cancer in children from undergoing CT
Commentary on: Pearce MS, Salotti JA, Little MP, et al.. Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet 2012;380:499–505. Context Use of ionising radiation in medical imaging has grown in recent decades. In some populations, its cumulative radiation dose approaches that from all other sources combined. This radiation burden has led to concerns about cancers caused by medical imaging. However, imaging studies expose patients to considerably lower radiation doses, and different types of radiation, than those received by most individ...
Source: Evidence-Based Medicine - July 5, 2013 Category: Internal Medicine Authors: Mercuri, M., Einstein, A. J. Tags: EBM Aetiology, Smoking and tobacco, Clinical trials (epidemiology), Epidemiologic studies, Screening (oncology), Radiology, Clinical diagnostic tests, Radiology (diagnostics), Health education, Smoking Source Type: research

Complementary and alternative medical interventions for the management of anxiety in parents of children who are hospitalized and suffer from a malignancy: A systematic review of RCTs
Conclusions: The methodological quality of reviewed RCT's studies was low and many failed to provide sufficient information in order to assess their quality on many of the methodological indicators. Although, the review did not provide strong evidence in favor of CAM interventions, the results were encouraging. The studies showed promising results and some positive trends such as the feasibility and acceptability of CAM interventions in pediatric oncology/hematology unit.
Source: European Journal of Integrative Medicine - November 4, 2013 Category: Complementary Medicine Authors: Theologia Tsitsi, Vasilios Raftopoulos, Evridiki Papastavrou, Andreas Charalambous Tags: Student Section Source Type: research