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Specialty: Cytology
Condition: Ischemic Stroke
Cancer: Brain Cancers
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Total 26 results found since Jan 2013.
Targeting p53 for neuroinflammation: New therapeutic strategies in ischemic stroke
We describe the function of p53, the major immune cells involved in neuroinflammation, and the role of p53 in inflammatory responses mediated by these cells. Finally, we summarize the therapeutic strategies of targeting p53 in regulating the neuroinflammatory response after IS to provide new directions and ideas for the treatment of ischemic brain injury.PMID:37156641 | DOI:10.1002/jnr.25200
Source: Cell Research - May 8, 2023 Category: Cytology Authors: Juan Gao Jifei Liu Yonghong Li Junxi Liu He Wang Miao Chai Ying Dong Zhenchang Zhang Gang Su Manxia Wang Source Type: research
Posttreatment with Ospemifene Attenuates Hypoxia- and Ischemia-Induced Apoptosis in Primary Neuronal Cells via Selective Modulation of Estrogen Receptors
Neurotox Res. 2023 May 2. doi: 10.1007/s12640-023-00644-5. Online ahead of print.ABSTRACTStroke and perinatal asphyxia have detrimental effects on neuronal cells, causing millions of deaths worldwide each year. Since currently available therapies are insufficient, there is an urgent need for novel neuroprotective strategies to address the effects of cerebrovascular accidents. One such recent approach is based on the neuroprotective properties of estrogen receptors (ERs). However, activation of ERs by estrogens may contribute to the development of endometriosis or hormone-dependent cancers. Therefore, in this study, we util...
Source: Cell Research - May 2, 2023 Category: Cytology Authors: Bernadeta A Pietrzak Agnieszka Wnuk Karolina Przepi órska Andrzej Łach Ma łgorzata Kajta Source Type: research
Cumulative Incidence of Thromboembolism and Prognostic Impact of Stroke in < em > BRAF < /em > V600E-mutant Non-small-cell Lung Cancer
CONCLUSION: A substantial proportion of patients with BRAF V600E-mutant lung cancer experienced thromboembolism during their disease course. CRS of undetermined source may predict a worse prognosis in this population.PMID:36697098 | DOI:10.21873/anticanres.16237
Source: Cell Research - January 25, 2023 Category: Cytology Authors: Sho Yamada Akimasa Sekine Eri Hagiwara Yoko Onodera Erina Tabata Satoshi Ikeda Hideya Kitamura Tomohisa Baba Shigeru Komatsu Takashi Ogura Source Type: research
Synthesis and Pharmacological Evaluation of Novel Triazole-Pyrimidine Hybrids as Potential Neuroprotective and Anti-neuroinflammatory Agents
CONCLUSION: The possible mechanism of action was observed through the inhibition of ER stress, apoptosis, and the NF-kB inflammatory pathway. Thus, our study strongly indicates that the novel scaffolds of triazole-pyrimidine-based compounds can potentially be developed as neuroprotective and anti-neuroinflammatory agents.PMID:36376607 | DOI:10.1007/s11095-022-03429-1
Source: Cell Research - November 14, 2022 Category: Cytology Authors: Shoaib Manzoor Daniyah A Almarghalani Antonisamy William James Md Kausar Raza Tasneem Kausar Shahid M Nayeem Nasimul Hoda Zahoor A Shah Source Type: research
Long non-coding RNA RPL34-AS1 ameliorates oxygen –glucose deprivation-induced neuronal injury via modulating miR-223–3p/IGF1R axis
In this study, RPL34-AS1 expression was reduced in patients suffering from ischemic s troke. The overexpression of RPL34-AS1 reduced ischemic brain damage. However, the cell viability and glucose uptake were increased, and the apoptosis rate was decreased in the OGD/R-induced neurons. Further, miR-223-3p resulted in the decreased cell viability and glucose uptake and the increased ce ll apoptosis to cause ischemic brain damage. Besides, the neuroprotective effects of RPL34-AS1 on OGD/R injury were partly reversed by miR-223–3p. Mechanistically, lncRNA RPL34-AS1 could function as the competing endogenous RNA (ceRNA) of mi...
Source: Human Cell - September 28, 2022 Category: Cytology Source Type: research
β2-Microglobulin exacerbates neuroinflammation, brain damage, and cognitive impairment after stroke in rats
In this study, we established a rat model of focal cerebral ischemia by occlusion of the middle cerebral artery. We found that β2M levels in the cerebral spinal fluid, serum, and brain tissue were significantly increased in the acute period but gradually decreased during the recovery period. RNA interference was used to inhibit β2M expression in the acute period of cerebral stroke. Tissue staining with 2,3,5-triphenyltetrazolium chloride and evaluation of cognitive function using the Morris water maze test demonstrated that decreased β2M expression in the ischemic penumbra reduced infarct volume and alleviated cognitive...
Source: Cell Research - August 26, 2022 Category: Cytology Authors: Feng Chen Jing Liu Fa-Qiang Li Shuai-Shuai Wang Yan-Yan Zhang Yun-Yun Lu Fang-Fang Hu Rui-Qin Yao Source Type: research
Exosomes Derived From Mesenchymal Stem Cells Pretreated With Ischemic Rat Heart Extracts Promote Angiogenesis via the Delivery of DMBT1
Cell Transplant. 2022 Jan-Dec;31:9636897221102898. doi: 10.1177/09636897221102898.ABSTRACTMesenchymal stem cell-derived exosomes (MSC-Exos) have been shown to promote angiogenesis. Treating MSCs with ischemic rat brain extracts was sufficient to augment their benefits in stroke. However, no similar analyses of ischemic heart extracts have been performed to date. We aim to determine whether MSC-Exos derived from MSCs pretreated with ischemic rat heart extract were able to promote angiogenesis and to clarify underlying mechanisms. ELISA (enzyme-linked immunosorbent assay) of heart extracts revealed a significant increase of ...
Source: Cell Transplantation - June 21, 2022 Category: Cytology Authors: Yi Xiao Ye Zhang Yuzhang Li Nanyin Peng Qin Liu Danyang Qiu Justin Cho Cesario V Borlongan Guolong Yu Source Type: research
Final Results of Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells in Acute Ischemic Stroke (AMASCIS): A Phase II, Randomized, Double-Blind, Placebo-Controlled, Single-Center, Pilot Clinical Trial
We report the final trial results after 24 months of follow-up. Recruitment began in December 2014 and stopped in December 2017 after 19 of 20 planned patients were included. Six patients did not receive study treatment: two due to technical issues and four for acquiring exclusion criteria after randomization. The final study sample was composed of 13 patients (4 receiving AD-MSCs and 9 placebo). One patient in the placebo group died within the first week after study treatment delivery due to sepsis. Two non-treatment-related serious AEs occurred in the AD-MSC group and nine in the placebo group. The total number of AEs an...
Source: Cell Transplantation - March 18, 2022 Category: Cytology Authors: Elena de Celis-Ruiz Blanca Fuentes Mar ía Alonso de Leciñana Mar ía Gutiérrez-Fernández Alberto M Borobia Raquel Guti érrez-Zúñiga Gerardo Ruiz-Ares Laura Otero-Ortega Fernando Laso-Garc ía Mari Carmen G ómez-de Frutos Exuperio D íez-Tejedor Source Type: research
Transcranial focused ultrasound stimulation reduces vasogenic edema after middle cerebral artery occlusion in mice
In this study of mice subjected to middle cerebral artery occlusion for 90 minutes, low-intensity low-frequency (0.5 MHz) transcranial focused ultrasound stimulation was applied 2, 4, and 8 hours after occlusion. Ultrasound stimulation reduced edema volume, improved neurobehavioral outcomes, improved BBB integrity (enhanced tight junction protein ZO-1 expression and reduced IgG leakage), and reduced secretion of the inflammatory factors tumor necrosis factor-α and activation of matrix metalloproteinase-9 in the ischemic brain. Our results show that low-intensity ultrasound stimulation attenuated BBB disruption and edema f...
Source: Cell Research - February 10, 2022 Category: Cytology Authors: Li-Dong Deng Lin Qi Qian Suo Sheng-Ju Wu Muyassar Mamtilahun Ru-Bing Shi Ze Liu Jun-Feng Sun Yao-Hui Tang Zhi-Jun Zhang Guo-Yuan Yang Ji-Xian Wang Source Type: research
