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Condition: Ischemic Stroke
Cancer: Brain Cancers

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Total 832 results found since Jan 2013.

Effect of Dihuang Yinzi on Inflammatory Response in Cerebral Ischemia-Reperfusion Model Rats by Regulating Gut Microbiota
Biomed Res Int. 2022 Aug 17;2022:3768880. doi: 10.1155/2022/3768880. eCollection 2022.ABSTRACTDihuang Yinzi, as a classical Chinese medicine prescription, plays an important role for the treatment of ischemic stroke. Gut microbiota play a functional role for the expression of proinflammatory cytokines and anti-inflammatory cytokines, which further affect central nervous system and change brain function. Our research confirmed that Dihuang Yinzi can exert brain protection by inhibiting inflammatory reaction. Dihuang Yinzi can significantly decrease the contents of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and...
Source: Biomed Res - August 29, 2022 Category: Research Authors: Xinyu Wang Lei Ye Wanru Sun Liya Li Chaoyun Wang Xiaoyan Xu Zhaohai Pan Jianwei Gong Source Type: research

β2-Microglobulin exacerbates neuroinflammation, brain damage, and cognitive impairment after stroke in rats
In this study, we established a rat model of focal cerebral ischemia by occlusion of the middle cerebral artery. We found that β2M levels in the cerebral spinal fluid, serum, and brain tissue were significantly increased in the acute period but gradually decreased during the recovery period. RNA interference was used to inhibit β2M expression in the acute period of cerebral stroke. Tissue staining with 2,3,5-triphenyltetrazolium chloride and evaluation of cognitive function using the Morris water maze test demonstrated that decreased β2M expression in the ischemic penumbra reduced infarct volume and alleviated cognitive...
Source: Cell Research - August 26, 2022 Category: Cytology Authors: Feng Chen Jing Liu Fa-Qiang Li Shuai-Shuai Wang Yan-Yan Zhang Yun-Yun Lu Fang-Fang Hu Rui-Qin Yao Source Type: research

Cancer ‐related stroke: Exploring personalized therapy strategies
ConclusionIn this review, we retrospectively analyzed the incidence, mechanisms of CRS, its potential as a new stroke subtype, options for acute treatment, secondary prevention strategies, and disease progression, with the aim of attempting to explore personalized therapy strategies.
Source: Brain and Behavior - August 8, 2022 Category: Neurology Authors: Yu ‐Jie Chen, Rui‐Guo Dong, Meng‐Meng Zhang, Chao Sheng, Peng‐Fei Guo, Jie Sun Tags: REVIEW Source Type: research

Acute ischemic stroke secondary to ventriculoperitoneal shunt dysfunction in a child with Moyamoya syndrome
CONCLUSION: Children who receive RT for brain tumor, particularly if the circle of Willis region is involved, require close surveillance for the development of vasculopathy and consequent stroke. This surveillance must be even tighter if the patient has been treated with ventricular shunt for the possible synergistic interaction between the two causes on reducing cerebral perfusion and increasing the risk of acute ischemic events.PMID:35928308 | PMC:PMC9345112 | DOI:10.25259/SNI_434_2022
Source: Surgical Neurology International - August 5, 2022 Category: Neurosurgery Authors: Francesca Vitulli Pietro Spennato Domenico Cicala Giuseppe Mirone Maria Rosaria Scala Giuseppe Cinalli Source Type: research

Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment
In conclusion, 5j has the potential for the treatment of stroke as an anti-inflammatory and neuroprotective agent.PMID:35931005 | DOI:10.1016/j.ejmech.2022.114597
Source: European Journal of Medicinal Chemistry - August 5, 2022 Category: Chemistry Authors: Hongwei Wang Enjing Cui Jiaming Li Xiaodong Ma Xueyang Jiang Shuaishuai Du Shihu Qian Le Du Source Type: research

Acute ischemic stroke secondary to ventriculoperitoneal shunt dysfunction in a child with Moyamoya syndrome
CONCLUSION: Children who receive RT for brain tumor, particularly if the circle of Willis region is involved, require close surveillance for the development of vasculopathy and consequent stroke. This surveillance must be even tighter if the patient has been treated with ventricular shunt for the possible synergistic interaction between the two causes on reducing cerebral perfusion and increasing the risk of acute ischemic events.PMID:35928308 | PMC:PMC9345112 | DOI:10.25259/SNI_434_2022
Source: Surgical Neurology International - August 5, 2022 Category: Neurosurgery Authors: Francesca Vitulli Pietro Spennato Domenico Cicala Giuseppe Mirone Maria Rosaria Scala Giuseppe Cinalli Source Type: research