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Guillain-Barr é Syndrome-Like Polyneuropathy Associated with Immune Checkpoint Inhibitors: A Systematic Review of 33 Cases
Biomed Res Int. 2021 Aug 19;2021:9800488. doi: 10.1155/2021/9800488. eCollection 2021.ABSTRACTImmune checkpoint inhibitors (ICIs) have been increasingly used in the treatment of various types of tumors with favorable results. But these treatments also led to a variety of immune-related adverse events (irAEs). Neurological irAEs such as Guillain-Barré Syndrome are rare and may have serious consequences once they occur. A systematic literature search was performed in PubMed and Embase for all case reports of GBS associated with ICIs published in English reporting on human beings from 1990 up to date. A total of 30 case repo...
Source: Biomed Res - August 30, 2021 Category: Research Authors: Yan Li Xiuchun Zhang Chuansheng Zhao Source Type: research
The Gut Microbiome and Cancer Immunotherapy: Can We Use the Gut Microbiome as a Predictive Biomarker for Clinical Response in Cancer Immunotherapy?
Conclusions: Overall, significant differences in the diversity and composition of the gut microbiome were identified in ICIs responders and non-responders. Our findings provide new insights into the value of assessing the gut microbiome in immunotherapy. Further robust randomized controlled trials (RCTs) examining the modulatory effects of the gut microbiome and FMT on ICIs in patients not responding to immunotherapy are warranted.PMID:34638308 | PMC:PMC8508052 | DOI:10.3390/cancers13194824
Source: Genomics Proteomics ... - October 13, 2021 Category: Genetics & Stem Cells Authors: Byeongsang Oh Frances Boyle Nick Pavlakis Stephen Clarke Thomas Eade George Hruby Gillian Lamoury Susan Carroll Marita Morgia Andrew Kneebone Mark Stevens Wen Liu Brian Corless Mark Molloy Benjamin Kong Towia Libermann David Rosenthal Michael Back Source Type: research
Predictive Role of Tumor-Stroma Ratio for Survival of Patients With Non-Small Cell Lung Cancer: A Meta-Analysis
Conclusion: Tumor TSR could be used as a predictor of survival in patients with NSCLC. The relative proportion of patients with SCC/AC in the included NSCLC patients may be an important determinant for the association between TSR and survival in NSCLC. Stroma richness may be a predictor of poor survival in patients with lung SCC, but a predictor of better survival in patients with lung AC.PMID:35132307 | PMC:PMC8817052 | DOI:10.3389/pore.2021.1610021
Source: Cell Research - February 8, 2022 Category: Cytology Authors: Xuefeng Zhang Hongfu Ma Liang Zhang Fenghuan Li Source Type: research
Prevalence of Merkel Cell Polyomavirus in Normal and Lesional Skin: A Systematic Review and Meta-Analysis
Front Oncol. 2022 Mar 22;12:868781. doi: 10.3389/fonc.2022.868781. eCollection 2022.ABSTRACTThe prevalence of Merkel cell polyomavirus(MCPyV) in Merkel cell carcinoma(MCC) and non-MCC skin lesions and its possible role in the etiology of other skin diseases remain controversial. To systematically assess the association between MCPyV infection and MCC, non-MCC skin lesions, and normal skin. For this systematic review and meta-analysis, a comprehensive search for eligible studies was conducted using Medline Ovid, Pubmed, Web of Science, and the Cochrane CENTRAL databases until August 2021; references were searched to identif...
Source: Cancer Control - April 8, 2022 Category: Cancer & Oncology Authors: Wilson A Wijaya Yu Liu Yong Qing Zhengyong Li Source Type: research
Carcinogenicity risk associated with tacrolimus use in kidney transplant recipients: a systematic review and meta-analysis
This report provides an up to date systematic review and evaluation of all relevant studies in the literature to determine the risk of malignancy in kidney transplant recipients exposed to tacrolimus.METHODS: A systematic literature search was performed using the Medline (PubMed and Ovid), Embase, Clinical Trials, and Cochrane databases (from creation to May 2021). We performed a meta-analysis of 11 studies with 36,985 kidney transplant recipients that compared the tacrolimus group with the control group. Outcomes of this study were incidence of malignancies and skin cancer risk. Risk of Bias was assessed in terms of wheth...
Source: Cancer Control - April 11, 2022 Category: Cancer & Oncology Authors: Liangping Wang Kuifen Ma Yao Yao Liang Yu Jianyong Wu Qingwei Zhao Ziqi Ye Source Type: research
Metabolomics of Esophageal Squamous Cell Carcinoma Tissues: Potential Biomarkers for Diagnosis and Promising Targets for Therapy
CONCLUSIONS: From the metabolomic data, 4 unknown compounds were found to be abnormally expressed in esophageal squamous cell carcinoma for the first time, such as 9,10-epoxy-12,15-octadecadienoate; 3 metabolites were found in multiple abnormal expression in another tumor, but upregulation or downregulation was found for the first time in esophageal cancer, such as oleoyl glycine; at the same time, it was further confirmed that five metabolites were abnormally expressed in esophageal squamous cell carcinoma, which was similar to the results of other studies, such as PE.PMID:35782075 | PMC:PMC9246618 | DOI:10.1155/2022/7819235
Source: Biomed Res - July 5, 2022 Category: Research Authors: Jia Xu Weiping Cao Aizhong Shao Ming Yang Vivian Andoh Qi Ge Hui-Wen Pan Ke-Ping Chen Source Type: research
Modern aspects of the use of natural polyphenols in tumor prevention and therapy
Front Cell Dev Biol. 2022 Sep 12;10:1011435. doi: 10.3389/fcell.2022.1011435. eCollection 2022.ABSTRACTPolyphenols are secondary plant metabolites or organic compounds synthesized by them. In other words, these are molecules that are found in plants. Due to the wide variety of polyphenols and the plants in which they are found, these compounds are divided according to the source of origin, the function of the polyphenols, and their chemical structure; where the main ones are flavonoids. All the beneficial properties of polyphenols have not yet been studied, since this group of substances is very extensive and diverse. Howe...
Source: Cancer Control - September 29, 2022 Category: Cancer & Oncology Authors: Galina Sufianova Ilgiz Gareev Ozal Beylerli Jianing Wu Alina Shumadalova Albert Sufianov Xin Chen Shiguang Zhao Source Type: research
Does human papillomavirus modify the risk of oropharyngeal cancer related to smoking and alcohol drinking? A systematic review and meta-analysis
CONCLUSIONS: This meta-analysis suggests a negative directed interaction of HPV and smoking; and HPV and heavy alcohol drinking in the development of primary OPSCC on stratified analysis and joint effect analysis.LEVEL OF EVIDENCE: 3A.PMID:36258880 | PMC:PMC9575072 | DOI:10.1002/lio2.877
Source: Cancer Control - October 19, 2022 Category: Cancer & Oncology Authors: Rawan T Arif Meaad A Mogaddam Leena A Merdad Nada J Farsi Source Type: research
The Use of Salivary Levels of Matrix Metalloproteinases as an Adjuvant Method in the Early Diagnosis of Oral Squamous Cell Carcinoma: A Narrative Literature Review
Curr Issues Mol Biol. 2022 Dec 12;44(12):6306-6322. doi: 10.3390/cimb44120430.ABSTRACTOral squamous cell carcinoma (OSCC) is an aggressive malignancy with increased mortality, in which the early diagnosis is the most important step in increasing patients' survival rate. Extensive research has evaluated the role of saliva as a source of diagnostic biomarkers, among which matrix metalloproteinases (MMPs) have shown a valuable potential for detecting even early stages of OSCC. The aim of this review was to present recent clinical data regarding the significance of salivary MMPs in the detection of early malignant transformati...
Source: Current Issues in Molecular Biology - December 22, 2022 Category: Molecular Biology Authors: Monica Monea Anca Maria Pop Source Type: research
