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Causal association between serum 25-Hydroxyvitamin D levels and cutaneous melanoma: a two-sample Mendelian randomization study
CONCLUSION: The findings indicated a potentially causal positive association between serum 25-Hydroxyvitamin D levels and melanoma risk, challenging traditional beliefs about vitamin D's role in melanoma. This emphasizes the need for a balanced and personalized approach to vitamin D supplementation and sun exposure, particularly in high-risk populations. These results should be interpreted with caution due to potential unrecognized pleiotropy and confounding factors. Future research should focus on validating these findings in diverse populations and exploring underlying biological mechanisms.PMID:37664026 | PMC:PMC1047062...
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Beichen Cai Qian Lin Ruonan Ke Xiuying Shan Jiaqi Yu Xuejun Ni Xinjian Lin Biao Wang Source Type: research

Salivary vitamin D levels among OSCC and normal Indian patients
Bioinformation. 2022 Oct 31;18(10):884-887. doi: 10.6026/97320630018884. eCollection 2022.ABSTRACTOral Squamous Cell Carcinoma comprises nearly 90% of all Oral cancers. Recent studies on Oral Squamous Cell Carcinoma are done with a focus on identification of factors that affect the outcome of treatment, one of which is vitamin D levels. The aim of this study was to evaluate vitamin D3 levels in patients with Oral Squamous Cell Carcinoma and Normal Population with saliva as a biomarker. The study sample comprised of 40 subjects, of whom 20 were patients diagnosed with OSCC and 20 healthy subjects. The salivary samples obtai...
Source: Bioinformation - September 1, 2023 Category: Bioinformatics Authors: Sandra Sagar Pratibha Raman S Gheena R Abilasha Reshma Poothakulath Krishnan J Selvaraj Source Type: research

Circulating vitamin D concentration and risk of 14 cancers: a bidirectional Mendelian randomization study
CONCLUSIONS: Our findings provide support for a causal relationship between circulating vitamin D concentration and risk of MSC. Additionally, we found a causal relationship between circulating vitamin D concentration and risk of colorectal cancer in reverse-MR analysis. This evidence indicate that vitamin D is of great significance in the prevention and treatment of MSC and the prognosis of colorectal cancer.PMID:37642723 | DOI:10.1007/s00432-023-05322-9
Source: Clinical Colorectal Cancer - August 29, 2023 Category: Cancer & Oncology Authors: Yuxuan Dai Yu Chen Yifu Pu Rui Jiang Source Type: research

PDIA3 modulates genomic response to 1,25 < sub > - < /sub > dihydroxyvitamin D < sub > 3 < /sub > in squamous cell carcinoma of the skin
Steroids. 2023 Aug 5:109288. doi: 10.1016/j.steroids.2023.109288. Online ahead of print.ABSTRACTAn active form of vitamin D3 (1,25-dihydroxyvitamin D3) acts through vitamin D receptor (VDR) initiating genomic response, but several studies described also non-genomic actions of 1,25-dihydroxyvitamin D3, implying the role of PDIA3 in the process. PDIA3 is a membrane-associated disulfide isomerase involved in disulfide bond formation, protein folding, and remodeling. Here, we used a transcriptome-based approach to identify changes in expression profiles in PDIA3-deficient squamous cell carcinoma line A431 after 1,25-dihydroxyv...
Source: Cancer Control - August 7, 2023 Category: Cancer & Oncology Authors: Joanna I Nowak Anna M Olszewska Anna Piotrowska Kamil Myszczy ński Pawe ł Domżalski Micha ł A Żmijewski Source Type: research

Metabolism of Lumisterol < sub > 2 < /sub > by CYP27A1
In conclusion, this study shows that L2 is not metabolized appreciably by CYP11A1, but it is a good substrate for CYP27A1 which hydroxylates its side chain to produce 3 major products that display anti-proliferative activity on skin-cancer cell lines.PMID:37499840 | DOI:10.1016/j.jsbmb.2023.106370
Source: Mol Biol Cell - July 27, 2023 Category: Molecular Biology Authors: Dongxian Wu Gareth Nealon Yuchen Liu Tae-Kang Kim Andrzej T Slominski Robert C Tuckey Source Type: research

Role of Vitamin D in Head and Neck Cancer-Immune Function, Anti-Tumour Effect, and Its Impact on Patient Prognosis
This article presents the data in line with increasing clinical credibility.PMID:37299554 | DOI:10.3390/nu15112592
Source: Cancer Control - June 10, 2023 Category: Cancer & Oncology Authors: Katarzyna Starska-Kowarska Source Type: research

Roles of Nuclear Receptors in Esophageal Cancer
CONCLUSION: The studies on the roles of NRs in EC have provided a theoretical basis for us to further understand the pathogenesis of EC and develop potential therapeutic drugs targeting NRs for the treatment of different diseases.PMID:36740804 | DOI:10.2174/1389201024666230202155426
Source: Current Pharmaceutical Biotechnology - February 6, 2023 Category: Biotechnology Authors: Lihao Deng Jiaxuan Liu Wei-Dong Chen Yan-Dong Wang Source Type: research

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