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Cancer: Ovarian Cancer
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Total 759 results found since Jan 2013.
Non-invasive evaluation of HABP1 expression with < sup > 99m < /sup > Tc-labeled small-interference RNA in ovarian cancer
CONCLUSIONS: We showed that 99mTc-HYNIC-siHABP1 is a feasible probe for the noninvasive visualization of HABP1 expression in ovarian cancer.PMID:34402389 | DOI:10.1080/09553002.2021.1969052
Source: International Journal of Radiation Biology - August 17, 2021 Category: Radiology Authors: Chunyu Duan Yue Gao Sha Luan Shibo Guo Xueliang Cao Peng Xu Peng Fu Changjiu Zhao Source Type: research
Noninvasive evaluation of HABP1 expression with < sup > 99m < /sup > Tc-labeled small-interference RNA in ovarian cancer
CONCLUSIONS: We showed that 99mTc-HYNIC-siHABP1 is a feasible probe for the noninvasive visualization of HABP1 expression in ovarian cancer.PMID:34402389 | DOI:10.1080/09553002.2021.1969052
Source: International Journal of Radiation Biology - August 17, 2021 Category: Radiology Authors: Chunyu Duan Yue Gao Sha Luan Shibo Guo Xueliang Cao Peng Xu Peng Fu Changjiu Zhao Source Type: research
Actin Beta-Like 2 as a New Mediator of Proliferation and Migration in Epithelial Ovarian Cancer
In this study, we analyzed the prognostic and functional significance of ACTBL2 and its regulatory element Nuclear factor of activated T-cells 5 (NFAT5). The expression of ACTBL2 and NFAT5 was examined in tissue microarrays of 156 ovarian cancer patients by immunohistochemistry. Aiming to assess the molecular impact of ACTBL2 on cellular characteristics, functional assays were executed in vitro upon siRNA knockdown of ACTBL2 and NFAT5. ACTBL2 expression was identified as an independent negative prognostic factor for overall survival of EOC patients. EOC cell lines showed a significantly increased mRNA and protein level of ...
Source: Frontiers in Oncology - September 23, 2021 Category: Cancer & Oncology Source Type: research
The inhibitory role of si-UBB delivered by degradable dendrimers-based lipid nanoparticles in ovarian cancer
Conclusions5A2SC8 complex was a safe and efficient gene delivery vehicle and ubiquitin B was a potential target for the ovarian cancer targeted therapy.
Source: Cancer Nanotechnology - January 29, 2022 Category: Cancer & Oncology Source Type: research
< em > Chelidonium majus < /em > Induces Apoptosis of Human Ovarian Cancer Cells Via ATF3-Mediated Regulation of Foxo3a by Tip60
This study demonstrated that Chelidonium majus upregulated the expression of ATF3 and Tip60 and promoted Foxo3a nuclear translocation, ultimately increasing the level of Bcl-2-associated X protein (Bax) protein. ATF3 overexpression stimulated Tip60 expression, while ATF3 inhibition by siRNA repressed Tip60 expression. Furthermore, siRNA-mediated Tip60 inhibition significantly promoted Foxo3a phosphorylation, leading to blockade of Foxo3a translocation into the nucleus. Thus, we were able to deduce that ATF3 mediates the regulation of Foxo3a by Tip60. Moreover, siRNA-mediated Foxo3a inhibition suppressed the expression of B...
Source: Journal of Microbiology and Biotechnology - March 14, 2022 Category: Biotechnology Authors: Lei Shen Soon Lee Jong Cheon Joo Eunmi Hong Zhen Yang Cui Eunbi Jo Soo Jung Park Hyun-Jin Jang Source Type: research
