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Rates of Influenza and Pneumococcal Vaccination and Correlation With Survival in Multiple Myeloma Patients
CONCLUSION: Vaccination is important in MM and should be encouraged. Vaccination status should be recorded in prospective clinical trials as it may affect survival. This trial was registered at www.CLINICALTRIALS: gov as #NCT02761187.PMID:36641358 | DOI:10.1016/j.clml.2022.12.003
Source: Clinical Lymphoma and Myeloma - January 14, 2023 Category: Cancer & Oncology Authors: Michael A Thompson Mario Boccadoro Xavier Leleu Jorge Vela-Ojeda Frits van Rhee Katja C Weisel Robert M Rifkin Saad Z Usmani Roman H ájek Gordon Cook Rafat Abonour Mira Armour Kathryn E Morgan Su-Peng Yeh Caitlin L Costello Jesus G Berdeja Faith E Davies Source Type: research

Vaccination coverage in hematological patients undergoing chemotherapy: Should we move towards personalized vaccination?
CONCLUSION: Despite vaccination opportunities, the complexity of these specific recommendations and the lack of communication between the health actors could explain the suboptimal vaccination coverage in this high-risk population. A proactive attitude of all actors in the city and hospital, including better patient information and a personalized and evolving vaccination schedule to help GPs to coordinate vaccination would allow to improve vaccine coverage.PMID:34740475 | DOI:10.1016/j.vaccine.2021.10.040
Source: Vaccine - November 6, 2021 Category: Allergy & Immunology Authors: Alix Pierron Fabienne Bozon Ana Berceanu Jean Fontan Annie Brion Erick Deconinck Catherine Chirouze Anne-Sophie Brunel Source Type: research

An allogeneic multiple myeloma GM-CSF-secreting vaccine with lenalidomide induces long-term immunity and durable clinical responses in patients in near complete remission
CONCLUSIONS: MM-GVAX, along with lenalidomide, effectively primed durable immunity and resulted long-term disease control, as suggested by the reappearance of a detectable, fluctuating M-spike without meeting the criteria for clinical relapse. For patients in a nCR, MM-GVAX administration was safe and resulted in prolonged clinical responses.PMID:34667029 | DOI:10.1158/1078-0432.CCR-21-1916
Source: Clinical Cancer Research - October 20, 2021 Category: Cancer & Oncology Authors: Luca Biavati Carol Ann Huff Anna Ferguson Amy Sidorski M Amanda Stevens Lakshmi Rudraraju Cristina Zucchinetti Syed Abbas Ali Philip Imus Christian B Gocke Rachel M Gittelman Sarah Johnson Catherine Sanders Marissa Vignali Anita Gandhi Xiaobu Ye Kimberly Source Type: research

B Cell Reconstitution and Influencing Factors After Hematopoietic Stem Cell Transplantation in Children
Nicolaas G. van der Maas, Dagmar Berghuis, Mirjam van der Burg and Arjan C. Lankester* Willem-Alexander Children's Hospital, Department of Pediatrics and Laboratory for Pediatric Immunology, Leiden University Medical Center, Leiden, Netherlands B cell reconstitution after hematopoietic stem cell transplantation (HSCT) is variable and influenced by different patient, donor, and treatment related factors. In this review we describe B cell reconstitution after pediatric allogeneic HST, including the kinetics of reconstitution of the different B cell subsets and the development of the B cell repertoire, and d...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Evidence Based Recommendations for Supportive Care in Multiple Myeloma
Conclusion:Along with anti-myeloma chemotherapy therapy, management of complications (anemia, infections, renal insufficiency) and other associated symptoms is necessary to improve the quality of life.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Qureshi, A., Tariq, M. J., Shah, Z., Abu Zar, M., Aslam, S., Rafae, A., Malik, M. N., Kamal, A., Jose, J. A., Selene, I. I., Shafqat, M., Jamil, F., Durer, S., Durer, C., Anwer, F. Tags: 653. Myeloma: Therapy, excluding Transplantation: Poster I Source Type: research