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Radiation-Induced Carotid Artery Stenosis: What Nurses Need to Know
This article provides an overview of the incidence, risk factors, detection, surveillance, and management of RI-CAS in cancer survivors.METHODS: A literature search was conducted using PubMed®, Embase®, and Web of Science for articles published from January 2008 through June 2022. Search terms included carotid stenosis, radiation therapy, and cancer survivors. This updated review includes content from older references, which serve as a literature-based foundation for the clinical care of cancer survivors at risk for or diagnosed with RI-CAS.FINDINGS: CAS is a long-term sequela of RT to the neck and can lead to serious co...
Source: Clinical Journal of Oncology Nursing - September 7, 2023 Category: Nursing Authors: Ellen Mullen Source Type: research

Clinical utility of serologic testing for celiac disease in asymptomatic patients: an evidence-based analysis.
The objective of this evidence-based analysis was to evaluate the clinical utility of serologic testing for celiac disease in asymptomatic individuals presenting with one of the non-gastrointestinal conditions evaluated in this report. The clinical utility was based on the effects of a gluten-free diet (GFD) on outcomes specific to each of these conditions. The prevalence of celiac disease in asymptomatic individuals and one of these non-gastrointestinal conditions was also evaluated. CLINICAL NEED AND TARGET POPULATION: CELIAC DISEASE: Celiac disease is an autoimmune disease characterized by a chronic inflammatory sta...
Source: Ontario Health Technology Assessment Series - December 20, 2015 Category: Journals (General) Tags: Ont Health Technol Assess Ser Source Type: research

Fight Aging! Newsletter, June 27th 2016
In conclusion, we showed for the first time that 7-KC induces oxidative stress via lysosomal dysfunction, resulting in exacerbation of calcification. CHIMERIC ANTIGEN RECEPTOR CANCER THERAPIES CAN NOW TARGET SOLID TUMORS https://www.fightaging.org/archives/2016/06/chimeric-antigen-receptor-cancer-therapies-can-now-target-solid-tumors/ If the research community is to win in the fight to cure cancer, and win soon enough to matter for all of us, then the focus must be on technology platforms that can be easily and cheaply adapted to many different types of cancer. The biggest strategic problem in the field is tha...
Source: Fight Aging! - June 26, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

What do we know about psychological outcomes of lymphoma in adults?
The goal of this review is to present the results of research on the influence of lymphoma on patients’ emotional status and cognitive functioning. A literature search was conducted to identify articles in English that investigated short- and long-term psychological outcomes of lymphoma and lymphoma treatment. Studies published prior to July 2016 were located by an electronic search using relevant databases such as ScienceDirect and PubMed. The search terms used included both medical subject headings and keywords such as “Hodgkin lymphoma,” “non-Hodgkin lymphoma,” “therapy,” “treatment,” “malignant,” ...
Source: European Psychologist - September 11, 2017 Category: Psychiatry & Psychology Source Type: research

Gastrosplenic fistula occurring in lymphoma patients: Systematic review with a new case of extranodal NK/T-cell lymphoma.
CONCLUSION: This systematic review provides an overview of GSF occurring in lymphomas, and will be helpful in making physicians aware of this rare disease entity. PMID: 29085199 [PubMed - in process]
Source: World Journal of Gastroenterology - September 21, 2017 Category: Gastroenterology Authors: Kang DH, Huh J, Lee JH, Jeong YK, Cha HJ Tags: World J Gastroenterol Source Type: research

Hematological Side Effects of Immune Checkpoint Inhibitors: The Example of Immune-Related Thrombocytopenia
Conclusion Hem-irAEs are potentially life-threatening complications of ICIs that require a high level of clinical suspicion. Ir-TCP is amongst the most frequently reported hem-irAEs. Due to its low incidence and the lack of specific diagnostic criteria, ir-TCP may be underdiagnosed and possibly underreported. The diagnosis is based on exclusion of other causes of TCP together with clinical features that suggest an immune event such as the refractoriness to platelet transfusions and response to corticosteroids. During clinical development, a systematic analysis of ir-TCP cases at clinical study and program level is of outm...
Source: Frontiers in Pharmacology - April 25, 2019 Category: Drugs & Pharmacology Source Type: research

Fight Aging! Newsletter, May 4th 2020
The objective is to start treating chronic diseases from the root and not the symptoms of the disease. As we are starting to enroll patients in "senolytics-clinical trials," it will be imperative to assess if senolysis efficiently targets the primary cause of disease or if it works best in combination with other drugs. Additional basic science research is required to address the fundamental role of senescent cells, especially in the established contexts of disease. Notes on Self-Experimentation with Sex Steroid Ablation for Regrowth of the Thymus https://www.fightaging.org/archives/2020/04/notes-on-self-experim...
Source: Fight Aging! - May 3, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs