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Cancer: Lymphoma
Nutrition: Zinc
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Total 115 results found since Jan 2013.
BACH1 loss exerts antitumor effects on mantle cell lymphoma cells via inducing a tumor-intrinsic innate immune response and cell cycle arrest
Mol Cancer Res. 2023 Sep 15. doi: 10.1158/1541-7786.MCR-23-0424. Online ahead of print.ABSTRACTBTB and CNC homology 1 (BACH1) is a transcription repressor that regulates multiple physiological processes including intracellular heme homeostasis and immune responses. Increasing lines of evidence indicate that BACH1 reshapes metastasis and metabolism of human solid tumors. However, its potential roles in mantle cell lymphoma (MCL) remain largely unknown. Here we found that silencing BACH1 in MCL cells induced markedly cell-cycle arrest and cell apoptosis, whereas overexpression of BACH1 exhibited the opposite patterns. Increa...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Guilan Li Min Feng Ziting Zhang Jiangyuan Liu Han Zhang Source Type: research
Zinc Supplementation Reduces Testicular Cell Apoptosis in Mice and Improves Spermatogenic Dysfunction Caused by Marginal Zinc Deficiency
Biol Trace Elem Res. 2023 Jul 29. doi: 10.1007/s12011-023-03789-8. Online ahead of print.ABSTRACTZinc (Zn) is an important trace element in the human body and plays an important role in growth, development, and male reproductive functions. Marginal zinc deficiency (MZD) is common in the human population and can cause spermatogenic dysfunction in males. Therefore, the aim of this study was to investigate methods to improve spermatogenic dysfunction caused by MZD and to further explore its mechanism of action. A total of 75 4-week-old male SPF ICR mice were randomly divided into five groups (control, MZD, MZD + ZnY2, MZD + Z...
Source: Biological Trace Element Research - July 29, 2023 Category: Biology Authors: Xiangchao Zeng Ziqiong Wang Lu Yu Lei Wang Yueling Liu Yuxin Chen Chunhong Wang Source Type: research
Zinc oxide nanoparticles induce toxicity in diffuse large B-cell lymphoma cell line U2932 via activating PINK1/Parkin-mediated mitophagy
Biomed Pharmacother. 2023 Jun 10;164:114988. doi: 10.1016/j.biopha.2023.114988. Online ahead of print.ABSTRACTDiffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma. Zinc oxide (ZnO) nanoparticles have excellent anti-tumor properties in the biomedical field. The present study aimed to explore the underlying mechanism by which ZnO nanoparticles induce toxicity in DLBCL cells (U2932) via the PINK1/Parkin-mediated mitophagy pathway. After U2932 cells were exposed to various concentrations of ZnO nanoparticles, the cell survival rate, reactive oxygen species (ROS) generation, cell cycle arrest, and changes i...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 12, 2023 Category: Drugs & Pharmacology Authors: Zonghong Li Xuewei Yin Chunyi Lyu Teng Wang Wenhao Wang Jiachen Zhang Jinxin Wang Zhenzhen Wang Chen Han Ruixue Zhang Dadong Guo Ruirong Xu Source Type: research
Baicalin attenuates dexamethasone-induced apoptosis of bone marrow mesenchymal stem cells by activating the hedgehog signaling pathway
CONCLUSIONS: BA antagonizes Dex-induced apoptosis of human BMSCs by activating the HH signaling pathway. It is a potential candidate for preventing SONFH.PMID:36804262 | DOI:10.1097/CM9.0000000000002113
Source: Molecular Medicine - February 22, 2023 Category: Molecular Biology Authors: Bin Jia Yaping Jiang Yao Yao Yingxing Xu Yingzhen Wang Tao Li Source Type: research
A novel variant in BCL11B in an individual with neurodevelopmental delay: A case report
CONCLUSIONS: The BCL11B-related neurodevelopmental disorders are rare, and only 17 variants in 25 patients have been found to date. Our report expands the variants spectrum of BCL11B and increases the case of neurodevelopmental abnormalities.PMID:36683525 | DOI:10.1002/mgg3.2132
Source: Molecular Medicine - January 23, 2023 Category: Molecular Biology Authors: Yonglin Yu Xiaoyi Jia Hongwei Yin Hongfang Jiang Yu Du Fan Yang Zuozhen Yang Haifeng Li Source Type: research
Tempol and silymarin rescue from zinc-induced degeneration of dopaminergic neurons through modulation of oxidative stress and inflammation
Mol Cell Biochem. 2022 Dec 23. doi: 10.1007/s11010-022-04620-z. Online ahead of print.ABSTRACTOxidative stress and inflammation are the key players in the toxic manifestation of sporadic Parkinson's disease and zinc (Zn)-induced dopaminergic neurodegeneration. A synthetic superoxide dismutase (SOD) mimetic, tempol, and a naturally occurring antioxidant, silymarin protect against oxidative stress-mediated damage. The study intended to explore the effects of tempol and silymarin against Zn-induced dopaminergic neurodegeneration. Exposure to Zn produced neurobehavioral deficits and striatal dopamine depletion. Zn reduced glut...
Source: Cell Research - December 23, 2022 Category: Cytology Authors: Garima Singh Namrata Mittra Chetna Singh Source Type: research
