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MicroRNA-203-mediated Posttranscriptional Deregulation of CPEB4 Contributes to Colorectal Cancer Progression.
In this study, we demonstrated that CPEB4 is abundantly overexpressed in colorectal cancers and has the potential to be used for predicting clinical outcomes of colorectal cancer patients. We suppressed CPEB4 expression by small interfering RNA (siRNA) in SW480 and LOVO cells to clarify the role of CPEB4 on the cell apoptosis and proliferation in vitro. Further study revealed that knockdown of CPEB4 decreased the expression of anti-apoptotic protein B-cell lymphoma-extra large (Bcl-XL), but enhanced the expression of B-cell lymphoma-2-associated X (Bax). In addition, we indicated that CPEB4 is a novel target of miR-203, a ...
Source: Biochemical and Biophysical Research communications - September 7, 2015 Category: Biochemistry Authors: Zhong X, Xiao Y, Chen C, Wei X, Hu C, Ling X, Liu X Tags: Biochem Biophys Res Commun Source Type: research

Enhancement of Paclitaxel-induced breast cancer cell death via the Glycogen Synthesis Kinase-3β-mediated B-cell lymphoma 2 regulation.
Abstract Glycogen synthase kinase-3β (GSK-3β) is a serine/threonine protein kinase that is known to mediate cancer cell death. Here, we show that B-cell lymphoma 2 (Bcl-2), an anti-apoptotic protein, is regulated by GSK-3β and that GSK-3β-mediated regulation of Bcl-2 is crucial for mitochondrial-dependent cell death in paclitaxel-stimulated cells. We demonstrate that MCF7 GSK-3β siRNA cells are more sensitive to cell death than MCF7 GFP control cells and that in the absence of GSK-3β, Bcl-2 levels are reduced, a result enhanced by paclitaxel. Paclitaxel-induced JNK (c-Jun N-terminal kinase) activation is cri...
Source: BMB Reports - August 7, 2015 Category: Biochemistry Authors: Noh KT, Cha GS, Kang TH, Cho J, Jung ID, Kim KY, Ahn SC, You JC, Park YM Tags: BMB Rep Source Type: research

Histone deacetylase HDAC1 downregulates transcription of the serotonin transporter (5-HTT) gene in tumor cells.
In this study, we examined the expression of the serotonin transporter (5-HTT) and the role of histone deacetylases (HDACs) in regulating the 5-HTT gene in tumor cells. The 5-HTT gene expression was almost silenced in chicken lymphoma DT40, myelomonocytic tumor HD11 and hepatoma DU249 cells, compared to their physiological counterpart. In contrast, HDAC1 mRNA expression was increased in these cell lines. Indeed, the pan-HDAC inhibitor trichostatin A (TSA) enhanced the 5-HTT mRNA expression in several tumor cell lines including the human cell lines HepG2 and THP-1 and increased the 5-HT uptake in HD11 cells. In addition, tr...
Source: Biochimica et Biophysica Acta - May 26, 2015 Category: Biochemistry Authors: Phi van DK, Mühlbauer E, Phi-van L Tags: Biochim Biophys Acta Source Type: research

Hypoxia-induced STAT3 Contributes to Chemoresistance and Epithelial-Mesenchymal Transition in Prostate Cancer Cells.
This study suggests a new rationale for inhibiting cancer chemoresistance and EMT under hypoxia using anti-STAT3 strategies. PMID: 25701777 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - February 18, 2015 Category: Biochemistry Authors: Liu ZQ, Han YC, Fang JM, Hu F, Zhang X, Xu Q Tags: Biochem Biophys Res Commun Source Type: research

Histone deacetylases inhibitor trichostatin A increases the expression of Dleu2/miR-15a/16-1 via HDAC3 in non-small cell lung cancer.
Abstract Histone deacetylases (HDACs) inhibitor is a promising new approach to the treatment of lung cancer therapy via inhibiting cell growth and inducing apoptosis. miR-15a and miR-16-1 are important tumor suppressors through modulating B cell lymphoma 2 (Bcl-2), Cyclin D1, D2, and others. However, whether HDACs inhibitor modulates the expression of miR-15a/16-1 in lung cancer is still unknown. The purpose of our study was to identify a new miRNA-mediated mechanism which plays an important role in the anti-cancer effects of HDACs inhibitor. We found HDACs inhibitors trichostatin A (TSA) and sodium butyrate upreg...
Source: Molecular and Cellular Biochemistry - July 19, 2013 Category: Biochemistry Authors: Chen CQ, Chen CS, Chen JJ, Zhou LP, Xu HL, Jin WW, Wu JB, Gao SM Tags: Mol Cell Biochem Source Type: research

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