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Cancer: Chronic Leukemia
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Total 284 results found since Jan 2013.
The basophil: From control of immunity to control of leukemias
Ann Pharm Fr. 2021 May 27:S0003-4509(21)00074-2. doi: 10.1016/j.pharma.2021.05.005. Online ahead of print.ABSTRACTThe basophils, first described by Paul Ehlrich in 1879, are rare circulating cells, representing approximately 0.01 to 0.3% of the blood leukocytes. Until recently, these cells have been neglected because of their minority status among immune cells and because they show some similarities to mast cells residing in tissues. However, basophils and mast cells are now recognized as distinct cell lines and it appears that basophils have important and non-redundant functions, distinct from those of mast cells. On the ...
Source: Annales Pharmaceutiques Francaises - May 29, 2021 Category: Drugs & Pharmacology Authors: M Arock Source Type: research
Corrigendum Cryptotanshinone inhibits IgE ‑mediated degranulation through inhibition of spleen tyrosine kinase and tyrosine‑protein kinase phosphorylation in mast cells
In this study, novel function of CRT on phosphorylations of Lyn/Syk kinases in mast cells is elucidated for the first time. Furthermore, it is likely that this inhibitory effect of CRT on Lyn/Syk kinases negatively affected activities of their downstream signalling molecules including PLCγ, PKCδ, and IKKβ, which leads to decrease in mast cell degranulation by CRT treatment. Besides the inhibitory effect of CRT on mast cell degranulation, here we provide additional evidence that CRT exerts anti-AD effects through inactivation of MAPK and NF‑κB. It has been reported that CRT regulates the activities of MAPK and NF‑κ...
Source: Mol Biol Cell - July 19, 2021 Category: Molecular Biology Authors: Sumiyasuren Buyanravjikh Sora Han Sunyi Lee Ae Lee Jeong Hye In Ka Ji Young Park Ariundavaa Boldbaatar Jong-Seok Lim Myeong-Sok Lee Young Yang Source Type: research
M153 dasatinib therapy and hypogammaglobulinemia
We present the case of a patient on chronic dasatinib for B-cell. ALL who developed a common variable immunodeficiency (CVID)-like phenotype.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2021 Category: Allergy & Immunology Authors: S. Modi, L. Kaminsky, T. Al-Shaikhly Source Type: research
M079 a case of chronic lymphocytic leukemia unveiled in a patient presenting with eosinophilia
We present a case of chronic lymphocytic leukemia (CLL) uncovered by CBC obtained to phenotype asthma.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2021 Category: Allergy & Immunology Authors: A. Chastant, M. Le, E. Atkinson Source Type: research
CD8+ T-cells Co-expressing PD-1 and TIGIT Are Highly Frequent in Chronic Lymphocytic Leukemia
Iran J Allergy Asthma Immunol. 2021 Dec 8;20(6):751-763. doi: 10.18502/ijaai.v20i6.8027.ABSTRACTThe role of immune checkpoint receptors in T-cell exhaustion has been demonstrated in several cancers. We investigated the co-expression of TIGIT/PD-1 and LAG-3/PD-1 cells in patients with chronic lymphocytic leukemia (CLL). The frequencies of TIGIT+PD-1+CD8+and LAG-3+PD-1+CD8+cells and relative mRNA expression of LSECtin and CD155 were examined in PBMCs from 33 CLL patients and 20 controls. The percentage of TIGIT+PD-1+CD8+cells was significantly higher in CLL patients than in control subjects, with the preference in advanced s...
Source: Cancer Control - December 18, 2021 Category: Cancer & Oncology Authors: Reza Hajiasghar-Sharbaf Hossein Asgarian-Omran Reza Valadan Hadi Hossein-Nattaj Ramin Shekarriz Ehsan Zaboli Ghasem Janbabaei Mohsen Tehrani Source Type: research
Concomitant use of Tyrosine-Kinase Inhibitor and Mepolizumab in Asthma Secondary to Chronic Myeloid Leukemia with Hypereosinophilia
Source: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry - January 16, 2022 Category: Allergy & Immunology Authors: Gidaro, Antonio Salvi, Emanuele Carraro, Maria C. Rossi, Roberta Simona Castelli, Roberto Tags: Case report Source Type: research
CLL Patients ' Cured ' : 10 Years Post-Infusion, CAR T Cells Persist CLL Patients ' Cured ' : 10 Years Post-Infusion, CAR T Cells Persist
Two patients with chronic lymphocytic leukemia who were among the first to receive the groundbreaking therapy were still in remission a decade later.Medscape Medical News
Source: Medscape Allergy Headlines - February 3, 2022 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
IL-25 Impact on Malignant B Cells Survival and T Cells Activation in Chronic Lymphocytic Leukemia
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):299-311. doi: 10.18502/ijaai.v22i3.13058.ABSTRACTT cell dysregulation and shift to T helper 2 responses, boosting tumor microenvironment support, contributes to the survival of leukemic B cells in Chronic Lymphocytic Leukemia. Interleukin (IL)-25 is involved in the initiation of T helper 2 cell responses. Signal transduction of IL-25 begins with the heterodimer receptor (IL-17RA/IL-17RB). The presence of IL-25 in the tumor microenvironment may affect the supportive effects of T cells in the surrounding tumor cell environment. The purpose of this study was to evaluate the rol...
Source: Cancer Control - July 31, 2023 Category: Cancer & Oncology Authors: Mehrnoosh Pashei Farahnaz Ghahremanfard Ehsan Manouchehri Doulabi Maral Hemmati Fatemeh Pak Parviz Kokhaei Source Type: research
