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Specialty: Neurology
Cancer: Leukemia
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Total 63 results found since Jan 2013.
Prospective assessment of vincristine-induced peripheral neuropathy in paediatric acute lymphoblastic leukemia
CONCLUSIONS: Clinical and neurophysiological evaluation of VIPN suggests vincristine produces a motor-prominent sensorimotor neuropathy in children which persisted at follow-up.SIGNIFICANCE: VIPN signs and symptoms develop early in the treatment course, in line with axonal excitability profiles. Early detection of significant nerve changes may support timely implementation of neuroprotection strategies.PMID:37633123 | DOI:10.1016/j.clinph.2023.08.002
Source: Clinical Neurophysiology - August 26, 2023 Category: Neurology Authors: Tiffany Li Tejaswi Kandula Richard J Cohn Matthew C Kiernan Susanna B Park Michelle A Farrar Source Type: research
Early life cancer and chemotherapy lead to cognitive deficits related to alterations in microglial-associated gene expression in prefrontal cortex
Brain Behav Immun. 2023 Jul 17:S0889-1591(23)00182-4. doi: 10.1016/j.bbi.2023.07.009. Online ahead of print.ABSTRACTChildren that survive leukemia are at an increased risk for cognitive difficulties. A better understanding of the neurobiological changes in response to early life chemotherapy will help develop therapeutic strategies to improve quality of life for leukemia survivors. To that end, we used a translationally-relevant mouse model consisting of leukemic cell line (L1210) injection into postnatal day (P)19 mice followed by methotrexate, vincristine, and leucovorin chemotherapy. Beginning one week after the end of ...
Source: Brain, Behavior, and Immunity - July 19, 2023 Category: Neurology Authors: Collin Laaker Claire Cantelon Alyshia Davis Kelsey R Lloyd Nana Agyeman Adam Hiltz Brittany L Smith Jan Pieter Konsman Teresa M Reyes Source Type: research
Relapsing GABA(A) Encephalitis After Stem Cell Transplant for Acute Myeloid Leukaemia
Can J Neurol Sci. 2023 Jul 12:1-9. doi: 10.1017/cjn.2023.252. Online ahead of print.NO ABSTRACTPMID:37434473 | DOI:10.1017/cjn.2023.252
Source: The Canadian Journal of Neurological Sciences - July 12, 2023 Category: Neurology Authors: Joshua Chin Ern Ooi Presaad Pillai Shirley Lee Sheila Ai Mei Ong Kee Leong Koh Yuen Kang Chia Source Type: research
Neuregulin-1/PI3K signaling effects on oligodendrocyte proliferation, remyelination and behaviors deficit in a male mouse model of ischemic stroke
In this study, we investigated the effect of neuregulin-1 (NRG1) on demyelination and neurological function in an ischemic stroke model, and further explored its neuroprotective mechanisms. Adult male ICR mice underwent photothrombotic ischemia surgery and were injected with NRG1 beginning 30 min after ischemia. Cylinder and grid walking tests were performed to evaluate the forepaw function. In addition, the effect of NRG1 on neuronal damage/death (Cresyl violet, CV), neuronal nuclei (NeuN), nestin, doublecortin (DCX), myelin basic protein (MBP), non-phosphorylated neurofilaments (SMI-32), adenomatous polyposis coli (APC),...
Source: Experimental Neurology - January 23, 2023 Category: Neurology Authors: Mai Yin Cui Yan Qiong Fu Zhuo Li Li Yu Zheng Yi Yu Chan Zhang Yun Qi Zhang Bing Rui Gao Wu Yue Chen Yun-Lyul Lee Moo-Ho Won Min Liao Yong Jian Bai Hui Chen Source Type: research
Ethanol-induced ceramide production causes neuronal apoptosis by increasing MCL-1S-mediated ER-mitochondria contacts
In conclusion, we suggest that ethanol-induced ceramide production may lead to mitochondrial calcium overload through MCL-1S-mediated INF2 activation-dependent MAM formation, which promotes neuronal apoptosis.PMID:36689912 | DOI:10.1016/j.nbd.2023.106009
Source: Neurobiology of Disease - January 23, 2023 Category: Neurology Authors: Jae Ryong Lim Chang Woo Chae Ji Yong Park Young Hyun Jung Jee Hyeon Yoon Min Jeong Kim Hyun Jik Lee Gee Euhn Choi Ho Jae Han Source Type: research
Neuregulin-1/PI3K signaling effects on oligodendrocyte proliferation, remyelination and behaviors deficit in a male mouse model of ischemic stroke
In this study, we investigated the effect of neuregulin-1 (NRG1) on demyelination and neurological function in an ischemic stroke model, and further explored its neuroprotective mechanisms. Adult male ICR mice underwent photothrombotic ischemia surgery and were injected with NRG1 beginning 30 min after ischemia. Cylinder and grid walking tests were performed to evaluate the forepaw function. In addition, the effect of NRG1 on neuronal damage/death (Cresyl violet, CV), neuronal nuclei (NeuN), nestin, doublecortin (DCX), myelin basic protein (MBP), non-phosphorylated neurofilaments (SMI-32), adenomatous polyposis coli (APC),...
Source: Experimental Neurology - January 23, 2023 Category: Neurology Authors: Mai Yin Cui Yan Qiong Fu Zhuo Li Li Yu Zheng Yi Yu Chan Zhang Yun Qi Zhang Bing Rui Gao Wu Yue Chen Yun-Lyul Lee Moo-Ho Won Min Liao Yong Jian Bai Hui Chen Source Type: research
Ethanol-induced ceramide production causes neuronal apoptosis by increasing MCL-1S-mediated ER-mitochondria contacts
In conclusion, we suggest that ethanol-induced ceramide production may lead to mitochondrial calcium overload through MCL-1S-mediated INF2 activation-dependent MAM formation, which promotes neuronal apoptosis.PMID:36689912 | DOI:10.1016/j.nbd.2023.106009
Source: Neurobiology of Disease - January 23, 2023 Category: Neurology Authors: Jae Ryong Lim Chang Woo Chae Ji Yong Park Young Hyun Jung Jee Hyeon Yoon Min Jeong Kim Hyun Jik Lee Gee Euhn Choi Ho Jae Han Source Type: research
