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Detection of red cell alloantibody prior to overflow phenomenon in a case of warm AIHA secondary to Chronic Lymphocytic Leukemia and Myasthenia Gravis: A Case Report
CONCLUSION: This case emphasizes the significance of understanding the overflow phenomenon in AIHA as it can guide a transfusion medicine specialist in early detection and identification of underlying alloantibodies which is crucial for appropriate transfusion management in AIHA. However, early presentation and timely workup along with high level of suspicion is crucial to identify this phenomenon.PMID:37689387 | DOI:10.1016/j.tracli.2023.09.001
Source: Transfusion Clinique et Biologique - September 9, 2023 Category: Hematology Authors: Davood Bava Vasanth Asirvatham Saptarshi Mandal Amit Kumar Rohilla Siddharth Mittal Source Type: research
The 'inbetweeners': living on a watch and wait approach for chronic lymphocytic leukaemia - a qualitative study
CONCLUSIONS: A greater understanding of how information provision affects levels of anxiety and worry among people living with CLL on watch and wait is needed. In addition, clinical nurse specialists could deliver education on the watch and wait approach, supplemented by video-based educational materials developed by the haematology team.PMID:37682762 | DOI:10.12968/bjon.2023.32.16.794
Source: British Journal of Nursing - September 8, 2023 Category: Nursing Authors: Claire Dunnion Martina Giltenane Maura Dowling Source Type: research
Aggressive chronic lymphocytic leukemia masked by extensive marrow fibrosis
We present an uncommon case of a patient initially diagnosed with primary myelofibrosis but later revealed to have aggressive CLL leading to bone marrow fibrosis upon re-evaluation. Treatment for CLL resolved the bone marrow fibrosis completely, confirming our suspicion of fibrosis being secondary to CLL. This sheds light on the importance of understanding the etiology of bone marrow fibrosis in patients with CLL owing to its therapeutic implications. The utility of bone marrow biopsy in not only helping understand the etiology of the fibrosis but also providing prognostic information merits reconsideration of performing i...
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Hareem Farooq Ke Li Talha Badar Source Type: research
The 'inbetweeners': living on a watch and wait approach for chronic lymphocytic leukaemia - a qualitative study
CONCLUSIONS: A greater understanding of how information provision affects levels of anxiety and worry among people living with CLL on watch and wait is needed. In addition, clinical nurse specialists could deliver education on the watch and wait approach, supplemented by video-based educational materials developed by the haematology team.PMID:37682762 | DOI:10.12968/bjon.2023.32.16.794
Source: British Journal of Nursing - September 8, 2023 Category: Nursing Authors: Claire Dunnion Martina Giltenane Maura Dowling Source Type: research
BCR::ABL1-negative myeloproliferative neoplasms in the era of next-generation sequencing
The classical BCR::ABL1-negative myeloproliferative neoplasms such as polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF) are clonal diseases with the presence of characteristic “driver mutations” in one of the genes: JAK2, CALR, or MPL. The search for mutations in these three genes is required for the diagnosis of MPNs. Nevertheless, the progress that has been made in the field of molecular genetics has opened a new era in medicine. The search for additional mutations in MPNs is helpful in assessing the risk stratification, disease progression, transformation to acute myeloid leukemia (AML),...
Source: Frontiers in Genetics - September 8, 2023 Category: Genetics & Stem Cells Source Type: research
Frequent, high density expression of surface CD38 as a potential therapeutic target in adult T-lineage acute lymphoblastic leukemia
Haematologica. 2023 Sep 7. doi: 10.3324/haematol.2023.283814. Online ahead of print.ABSTRACTNot available.PMID:37675513 | DOI:10.3324/haematol.2023.283814
Source: Haematologica - September 7, 2023 Category: Hematology Authors: Sebastian Koslowski Rainer Glauben Stefan Habringer Thomas Burmeister Ulrich Keller Monika Br üggemann Nicola G ökbuget Stefan Schwartz Source Type: research
Maximal benefit of minimal residual disease monitoring in pediatric acute myeloid leukemia
Haematologica. 2023 Sep 7. doi: 10.3324/haematol.2023.283765. Online ahead of print.ABSTRACTNot available.PMID:37675508 | DOI:10.3324/haematol.2023.283765
Source: Haematologica - September 7, 2023 Category: Hematology Authors: Henrik Hasle Kristian L øvvik Juul-Dam Source Type: research
A commentary on the optimal red blood cell transfusion threshold in acute leukemia patients
Blood Transfus. 2023 Sep 4. doi: 10.2450/BloodTransfus.594. Online ahead of print.NO ABSTRACTPMID:37677098 | DOI:10.2450/BloodTransfus.594
Source: Blood Transfusion - September 7, 2023 Category: Hematology Authors: Akua Asante Phuong-Lan Nguyen Neil Blumberg Source Type: research
Unique blast phase of chronic myeloid leukemia with concurrent erythroid and megakaryocytic differentiation
Int J Lab Hematol. 2023 Sep 6. doi: 10.1111/ijlh.14167. Online ahead of print.NO ABSTRACTPMID:37674279 | DOI:10.1111/ijlh.14167
Source: International Journal of Laboratory Hematology - September 7, 2023 Category: Hematology Authors: Shuyu E Karen A Nahmod Sa A Wang C Cameron Yin Source Type: research
Generation of CHOPi-008-B, a euploid iPSC line from a patient with Trisomy 21 and a GATA1 mutation
Stem Cell Res. 2023 Sep 1;72:103198. doi: 10.1016/j.scr.2023.103198. Online ahead of print.ABSTRACTTransient myeloproliferative disorder (TMD) is a pre-leukemic condition that occurs only in neonates with Trisomy 21 (T21), and is attributed to a genetic interaction between the third copy of chromosome 21 (HSA21) and a mutation in the transcription factor GATA1 that results in a truncated protein (GATA1s). We generated a euploid iPSC line with a GATA1s mutation that is isogenic to a previously published pair of T21 lines with and without a GATA1 mutation. The line was characterized for pluripotency, differentiation potentia...
Source: Cell Research - September 7, 2023 Category: Cytology Authors: Kaoru Takasaki Sara S Kumar Alyssa Gagne Deborah L French Stella T Chou Source Type: research
