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Phloretin induces G2/M arrest and apoptosis by suppressing the β-catenin signaling pathway in colorectal carcinoma cells
In conclusion, our results strongly suggested that phloretin can be utilized as a nutraceutical anticancer agent for combating CRC.PMID:36884140 | DOI:10.1007/s10495-023-01826-4
Source: Cell Research - March 8, 2023 Category: Cytology Authors: Smita Kapoor Yogendra S Padwad Source Type: research

Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer
CONCLUSIONS: Our findings highlight a novel anti-tumoral mechanism of curcumin through its action on NCLX and mitochondria calcium overload that could benefit for therapeutic schedule of patients with MSI CRC.PMID:35526196 | DOI:10.1007/s00018-022-04311-4
Source: Cellular and Molecular Life Sciences : CMLS - May 8, 2022 Category: Cytology Authors: Maxime Gu éguinou Sajida Ibrahim J érôme Bourgeais Alison Robert Trayambak Pathak Xuexin Zhang David Crott ès Jacques Dupuy David Ternant Val érie Monbet Roseline Guibon Hector Flores-Romero Antoine Lef èvre St éphanie Lerondel Alain Le Pape Jean-F Source Type: research

Zeolites as Carriers of Antitumor Ribonuclease Binase
In this study we tested the clinoptilolite, chabazite, and natrolite ability to be loaded by antitumor ribonuclease binase and the cytotoxicity of the obtained complexes. We found the optimal conditions for binase loading into zeolites and established the dynamic of its release. Cytotoxic effects of zeolite-binase complexes toward colorectal cancer Caco2 cells were characterized after 24 and 48 h of incubation with cells using MTT-test. Zeolites were toxic by itselfs and reduced cells viability by 30% (clinoptilolite), 40% (chabazite), and 70% (natrolite) after 48 h of incubation. Binase complexes with clinoptilolite as we...
Source: Frontiers in Pharmacology - May 2, 2019 Category: Drugs & Pharmacology Source Type: research