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Allergen immunotherapy, cancer, and immune disorders
Purpose of review The purpose of this review is to provide an update on the intriguing relationships between allergies, allergen immunotherapy, cancer, and immune disorders. Allergic diseases and cancer are increasing in incidence and prevalence and a potential relationship, or not, between these diseases have been suggested for many years. Recent findings Recent findings suggest that there may be some causative effects between certain types of cancer and allergic diseases, as described in the text. Some types of cancer may be more linked to the presence of an allergic disease, than others. However, epigenetic f...
Source: Current Opinion in Allergy and Clinical Immunology - November 4, 2022 Category: Allergy & Immunology Tags: IMMUNOTHERAPY AND NEW TREATMENTS: Edited by Giovanni Passalacqua and Robert Bush Source Type: research

Human Gut-Associated Natural Killer Cells in Health and Disease
Alessandro Poggi1*, Roberto Benelli2, Roberta Venè1, Delfina Costa1, Nicoletta Ferrari1, Francesca Tosetti1 and Maria Raffaella Zocchi3 1Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 3Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Nanoallergen platform for detection of platin drug allergies
Platinum-based antineoplastic agents (platins) are the most frequently used chemotherapeutics in patients with a variety of cancers, such as ovarian, colorectal, endometrial, and pancreatic cancer among others, and their use is associated with an increase in drug hypersensitivity reactions (DHRs).1 In particular, 2 commonly used platins, oxaliplatin and carboplatin, have high rates of DHR: carboplatin DHR rates range from 9% to 27%, whereas oxaliplatin DHR rates are as high as 25% and typically manifest between the fifth and seventh infusions.
Source: Journal of Allergy and Clinical Immunology - January 22, 2019 Category: Allergy & Immunology Authors: Peter E. Deak, Baksun Kim, Ather Adnan, Marina Labella, Leticia De las Vecillas, Mariana Castells, Basar Bilgicer Tags: Letter to the Editor Source Type: research