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Inhibition of microRNA-21-3p suppresses proliferation as well as invasion and induces apoptosis by targeting RBPMS through Smad4/ERK signaling pathway in human colorectal cancer HCT116 cells.
This study aimed to investigate the key role of miR-21-3p in CRC by inhibiting its expression using transfection with miR-21-3p inhibitors into human CRC HCT116 cells. Results showed that the expression of miR-21-3p was higher than other CRC cells used in the study including Lovo, HT29, Colo320 and SW480 cells, inhibition of which suppressed the proliferation and induced cell cycle arrest in HCT116 cells. Besides, transfection with miR-21-3p inhibitors also attenuated cell migration and invasion, and induced apoptosis as well. Moreover, luciferase assay confirmed RBPMS as a direct target of miR-21-3p in HCT116 cells. Furth...
Source: Clinical and Experimental Pharmacology and Physiology - March 14, 2018 Category: Drugs & Pharmacology Authors: Hou N, Guo Z, Zhao G, Jia G, Luo B, Shen X, Bai Y Tags: Clin Exp Pharmacol Physiol Source Type: research

Invited submission to the Diamond Jubilee Special Issue of Biochemical PharmacolLeptin induces SIRT1 expression through activation of NF-E2-related factor 2: implications for obesity-associated colon carcinogenesis.
In conclusion, leptin might play a role in colon carcinogenesis by inducing Nrf2-dependent SIRT1 overexpression. PMID: 29427626 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - February 7, 2018 Category: Drugs & Pharmacology Authors: Song NY, Lee YH, Na HK, Baek JH, Surh YJ Tags: Biochem Pharmacol Source Type: research

Silencing of hsa_circ_0007534 suppresses proliferation and induces apoptosis in colorectal cancer cells.
CONCLUSIONS: Hsa_circ_0007534 plays a crucial role in the initiation and progression of CRC and may be a potential therapeutic target of CRC. PMID: 29364478 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - January 26, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

MiRNA-155 promotes the invasion of colorectal cancer SW-480 cells through regulating the Wnt/ β-catenin.
CONCLUSIONS: The findings of this study suggest that miR-155 and β-catenin may have a unique potential as a novel biomarker candidate for diagnosis and treatment of tumor metastasis. PMID: 29364476 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - January 26, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Suppression of Capn4 by microRNA-1271 impedes the proliferation and invasion of colorectal cancer cells
In this study, we aimed to investigate the potential role of Capn4 in CRC and the regulation of Capn4 by microRNAs (miRNAs). Here, we found that Capn4 expression was highly up-regulated in CRC cell lines. Knockdown of Capn4 by siRNA significantly inhibited the proliferation and invasion of CRC cell lines. Furthermore, knockdown of Capn4 suppressed Wnt signaling in CRC cells. Interestingly, Capn4 was found to be a target gene of miR-1271, a tumor suppressive miRNA. The results showed that miR-1271 negatively regulated Capn4 expression in CRC cells. An inverse correlation between miR-1271 and Capn4 was also shown in CRC clin...
Source: Biomedicine and Pharmacotherapy - January 21, 2018 Category: Drugs & Pharmacology Source Type: research

Suppression of Capn4 by microRNA-1271 impedes the proliferation and invasion of colorectal cancer cells.
In this study, we aimed to investigate the potential role of Capn4 in CRC and the regulation of Capn4 by microRNAs (miRNAs). Here, we found that Capn4 expression was highly up-regulated in CRC cell lines. Knockdown of Capn4 by siRNA significantly inhibited the proliferation and invasion of CRC cell lines. Furthermore, knockdown of Capn4 suppressed Wnt signaling in CRC cells. Interestingly, Capn4 was found to be a target gene of miR-1271, a tumor suppressive miRNA. The results showed that miR-1271 negatively regulated Capn4 expression in CRC cells. An inverse correlation between miR-1271 and Capn4 was also shown in CRC clin...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 10, 2018 Category: Drugs & Pharmacology Authors: Li J, Xu J, Yan X, Jin K, Li W, Zhang R Tags: Biomed Pharmacother Source Type: research

Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner
In conclusion, we confirmed the HDAC3-relied activity of butyrate on inhibiting motility of colorectal cancer cells via deactivating Akt/ERK signaling. Our data indicate that modulating butyrate metabolism is an effective therapeutic strategy of metastatic colorectal cancer; and HDAC3 might be a novel target for management of colorectal cancer metastasis.
Source: Journal of Pharmacological Sciences - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Monophosphorylation by deoxycytidine kinase affects apparent cellular uptake of decitabine in HCT116 colon cancer cells.
Authors: Ueda K, Masuda A, Fukuda M, Tanaka S, Hosokawa M, Iwakawa S Abstract Decitabine (DAC), a nucleoside-related DNA methylation inhibitor, is taken up into cancer cells via equilibrative nucleoside transporter 1 (ENT1), and is then monophosphorylated by deoxycytidine kinase (dCK). In the present study, we examined the contribution of dCK to the uptake of DAC in HCT116 colon cancer cells. Irinotecan and etoposide inhibited the uptake of [3H]-uridine and [3H]-DAC at 10 s and 5 min, while cytarabine and gemcitabine only inhibited that of [3H]-DAC at 5 min. Irinotecan and etoposide inhibited [3H]-DAC uptake in ...
Source: Drug Metabolism and Pharmacokinetics - November 29, 2017 Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research

Polymer nanoassemblies with hydrophobic pendant groups in the core induce false positive siRNA transfection in luciferase reporter assays
This study elucidates a cause of the false positive effect in luciferase assays by using polymer nanoassemblies (PNAs) made from PEG, PEI, poly-(l-lysine) (PLL), palmitate (PAL), and deoxycholate (DOC): PEG-PEI (2P), PEG-PEI-PAL (3P), PEG-PLL (2P’), PEG-PLL-PAL (3P’), and PEG-PEI-DOC (2PD). In vitro transfection and western blot assays of luciferase using a colorectal cancer cell line expressing luciferase (HT29/LUC) concluded that 2P and 2P’ caused no luciferase expression reduction while hydrophobically modified PNAs induced a 35–50% reduction (3P’<2PD<3P). Although cell viability remained stagnan...
Source: International Journal of Pharmaceutics - June 21, 2017 Category: Drugs & Pharmacology Source Type: research

FAM83D knockdown regulates proliferation, migration and invasion of colorectal cancer through inhibiting FBXW7/Notch-1 signalling pathway.
In conclusion, FAM83D knockdown promoted colorectal cancer cell apoptosis, inhibited cell proliferation, cell migration and invasion, which might be associated with inhibiting the FBXW7/Notch1 signal pathway. Our findings indicated that FAM83D is a promising molecular target for colorectal cancer treatment. PMID: 28407575 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2017 Category: Drugs & Pharmacology Authors: Mu Y, Zou H, Chen B, Fan Y, Luo S Tags: Biomed Pharmacother Source Type: research

H2S-induced S-sulfhydration of lactate dehydrogenase A (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells.
Abstract Cystathionine-β-synthase (CBS) is upregulated and hydrogen sulfide (H2S) production is increased in colon cancer cells. The functional consequence of this response is stimulation of cellular bioenergetics and tumor growth and proliferation. Lactate dehydrogenase A (LDHA) is also upregulated in various colon cancer cells and has been previously implicated in tumor cell bioenergetics and proliferation. In the present study, we sought to determine the potential interaction between the H2S pathway and LDH activity in the control of bioenergetics and proliferation of colon cancer, using the colon cancer line ...
Source: Biochemical Pharmacology - April 9, 2017 Category: Drugs & Pharmacology Authors: Untereiner AA, Oláh G, Módis K, Hellmich MR, Szabo C Tags: Biochem Pharmacol Source Type: research

Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer.
Abstract Circular RNAs (circRNAs) are recently identified as widespread and diverse endogenous noncoding RNAs that may harbor vital functions in human and animals. However, the role of circRNAs in the process of tumorigenesis and development of colorectal cancer (CRC) remains vague. Here we characterized the circRNA expression profile from three paired CRC cancerous and adjacent normal tissues by human circRNA array, and identified 136 significantly overexpressed circRNAs and 243 downregulated circRNAs in CRC cancerous tissues (>2-fold changes). We further validated one circRNA generated from Exon 5-11 of BANP ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 15, 2017 Category: Drugs & Pharmacology Authors: Zhu M, Xu Y, Chen Y, Yan F Tags: Biomed Pharmacother Source Type: research

Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer
Publication date: April 2017 Source:Biomedicine & Pharmacotherapy, Volume 88 Author(s): Mingchen Zhu, Yijun Xu, Yun Chen, Feng Yan Circular RNAs (circRNAs) are recently identified as widespread and diverse endogenous noncoding RNAs that may harbor vital functions in human and animals. However, the role of circRNAs in the process of tumorigenesis and development of colorectal cancer (CRC) remains vague. Here we characterized the circRNA expression profile from three paired CRC cancerous and adjacent normal tissues by human circRNA array, and identified 136 significantly overexpressed circRNAs and 243 downregulated ...
Source: Biomedicine and Pharmacotherapy - January 15, 2017 Category: Drugs & Pharmacology Source Type: research

The role of microRNAs in colorectal cancer
Publication date: December 2016 Source:Biomedicine & Pharmacotherapy, Volume 84 Author(s): Ali Mohammadi, Behzad Mansoori, Behzad Baradaran Colorectal cancer (CRC) is still the third most common cancer in the world. Mechanism of CRC tumorigenesis has been widely studied at the molecular levels, and has been recently entered the area of microRNAs. MicroRNAs are small 19 to 22 nucleotides of RNA that engage in the regulation of cell differentiation, apoptosis, and cell cycle progression. MicroRNAs are similar to small interfering RNA (siRNA), that post-transcriptionally regulate gene expression and control various c...
Source: Biomedicine and Pharmacotherapy - October 1, 2016 Category: Drugs & Pharmacology Source Type: research

The role of microRNAs in colorectal cancer.
Abstract Colorectal cancer (CRC) is still the third most common cancer in the world. Mechanism of CRC tumorigenesis has been widely studied at the molecular levels, and has been recently entered the area of microRNAs. MicroRNAs are small 19 to 22 nucleotides of RNA that engage in the regulation of cell differentiation, apoptosis, and cell cycle progression. MicroRNAs are similar to small interfering RNA (siRNA), that post-transcriptionally regulate gene expression and control various cellular mechanisms. They are important factors in the carcinogenesis of CRC, one of the most important factors includes microRNA. M...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 30, 2016 Category: Drugs & Pharmacology Authors: Mohammadi A, Mansoori B, Baradaran B Tags: Biomed Pharmacother Source Type: research

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