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Cancer: Head and Neck Cancer
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Total 98 results found since Jan 2013.

GCS Inhibition in HNC
This study investigates whether GCS is targetable in HNC by assessing whether GCS inhibition sensitizes HNC to cisplatin. The effect of genetic or pharmacologic GCS inhibition (using GCS siRNA/shRNA or d,l-threo-PPMP, respectively) on cisplatin sensitivity was assessed in several human HNC cells and acquired cisplatin-resistant HNC cells by measuring cell viability, cell cycle, death, mRNA and protein expression, ceramide production, and in preclinical tumor xenograft mouse models. GCS and P-gp expression were significantly associated with cisplatin resistance in several HNC cell lines (P = 0.007). Both were significantly ...
Source: Molecular Cancer Therapeutics - August 5, 2015 Category: Cancer & Oncology Authors: Roh, J.-L., Kim, E. H., Park, J. Y., Kim, J. W. Tags: Cancer Biology and Signal Transduction Source Type: research

Abstract 1428: Targeting RRM2 by siRNA inhibits cellular invasion and represents a rational approach for inhibition of metastasis of head and neck and lung cancers
Background: Ribonucleotide reductase subunit M2 (RRM2) has been frequently observed to be aberrantly overexpressed in various tumors. RRM2 is a key enzyme, and essential regulator of balanced deoxyribonucleotides (dNTPs). It is critical for DNA replication and repair, and hence cell survival. In addition to DNA synthesis, it has been reported to modulate cellular invasiveness. However, the mechanisms through which RRM2 affects the invasive phenotype have not been elucidated.Methods: We evaluated the expression of RRM2 protein in metastatic (n = 40) and non-metastatic (n = 40) head and neck squamous cell carcinoma (HNSCC) t...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Rahman, M. A., Amin, A. R. M. R., Zhang, J., Nannapaneni, S., Saba, N. F., Chen, Z. G., Shin, D. M. Tags: Tumor Biology Source Type: research

Abstract 5474: PD-L1 regulates cisplatin chemoresistance in head and neck squamous cell carcinoma
In conclusion, we have identified a novel role for PD-L1 in the development of chemoresistance through its interaction with the MRN complex, which plays a major role in the repair of chemo-induced DNA DSB. Therapies aimed at blocking PD-L1 show great promise because of their ability to enhance both chemotherapeutics and the anti-tumor immune response.Citation Format: Randall S. Ruffner, Andrew Ramsey, Bert W. O'Malley, Daqing Li. PD-L1 regulates cisplatin chemoresistance in head and neck squamous cell carcinoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Ap...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Ruffner, R. S., Ramsey, A., O'Malley, B. W., Li, D. Tags: Experimental and Molecular Therapeutics Source Type: research

Abstract 813: Human papillomavirus 16 oncoprotein E6 upregulates c-Met partially through p53 in squamous cell carcinoma of the head and neck
Conclusion: Our results show that c-Met expression is upregulated by HPV E6, which is partially mediated by p53. The data suggest that targeting c-Met may serve as a novel approach for treating HPV-associated OPSCC.(This study was supported by grants from Small Business Innovation Research (SBIR) Program (HHSN261201200097C), National Institutes of Health (R33 CA161873), and National Cancer Institute (NCI P50 CA 128613, Head and Neck SPORE).Citation Format: Guoqing Qian, Dongsheng Wang, Kelly R. Magliocca, Praveen Duggal, Sreenivas Nannapaneni, Sungjin Kim, Zhengjia Chen, Dong M. Shin, Nabil F. Saba, Zhuo G. Chen. Human pap...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Qian, G., Wang, D., Magliocca, K. R., Duggal, P., Nannapaneni, S., Kim, S., Chen, Z., Shin, D. M., Saba, N. F., Chen, Z. G. Tags: Carcinogenesis Source Type: research

Abstract 101: WHSC1L1 as a therapeutic target in squamous cell carcinoma of the head and neck
Conclusions: WHSC1L1 is genetically altered in multiple cancer types. In SCCHN, it is significantly overexpressed in 24% of the tumors and its knockdown caused significant growth suppression of both HPV-positive and HPV-negative SCCHN cell lines. Taken together, WHSC1L1 merits further investigation as a potential therapeutic target in SCCHN.Citation Format: Vassiliki Saloura, Theodore Vougiouklakis, Mark Lingen, Tanguy Seiwert, Everett Vokes, Yusuke Nakamura, Ryuji Hamamoto. WHSC1L1 as a therapeutic target in squamous cell carcinoma of the head and neck. [abstract]. In: Proceedings of the 106th Annual Meeting of the Americ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Saloura, V., Vougiouklakis, T., Lingen, M., Seiwert, T., Vokes, E., Nakamura, Y., Hamamoto, R. Tags: Molecular and Cellular Biology Source Type: research

Abstract 585: Elevated levels of CD24 in head and neck squamous carcinoma cells: A potential marker for unfavorable cisplatin response
Conclusion: Our work thus far, indicates that higher expression of CD24 in head and neck tumors result in a cisplatin resistant population that may well be the cause of unfavorable response to cisplatin treatment. Overall, CD24 has the potential to be a valuable predictor of response to cisplatin in HNSCC patients as well as a therapeutic target.Citation Format: Vishnu Modur. Elevated levels of CD24 in head and neck squamous carcinoma cells: A potential marker for unfavorable cisplatin response. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadel...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Modur, V. Tags: Clinical Research (Excluding Clinical Trials) Source Type: research

Abstract 20: Honokiol radiosensitizes squamous cells carcinoma of head and neck by down-regulation of survivin
Conclusions: Survivin is a negative prognostic factor in SCCHN, and is involved in DNA damage response and repair induced by IR in SCCHN cells. Down regulation of survivin by honokiol enhances the efficacy of IR, and may provide a novel therapeutic approach to improve the efficacy of radiotherapy in SCCHN. (This research was supported by the National Cancer Institute award P50 CA128613, and GCC Distinguished Cancer Scholar to Dong M. Shin, Zhuo (Georgia) Chen, and Jonathan J Beitler)Citation Format: Xu Wang, Jonathan J. Beitler, Wen Huang, Guoqing Qian, Kelly Magliocca, Jun Zhang, Sreenivas Nannapaneni, Sungjin Kim, Zhengj...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Wang, X., Beitler, J. J., Huang, W., Qian, G., Magliocca, K., Zhang, J., Nannapaneni, S., Kim, S., Chen, Z., Nabil, S. F., Chen, Z. G., Arbiser, J. L., Shin, D. M. Tags: Molecular and Cellular Biology Source Type: research

Abstract 353: Vorinostat enhances anti-tumor effects of cisplatin in head and neck cancer cells by targeting cancer stem cells
Conclusions: Taken together, our results suggest that targeting of HDACs with Vorinostat could be an effective treatment strategy for the treatment of HNSCC patients that do not respond to currently used treatment regimens.Citation Format: Bhavna Kumar, Arti Yadav, Theodoros N. Teknos, Pawan Kumar. Vorinostat enhances anti-tumor effects of cisplatin in head and neck cancer cells by targeting cancer stem cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 353. doi:10...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Kumar, B., Yadav, A., Teknos, T. N., Kumar, P. Tags: Tumor Biology Source Type: research

Anticancer activity of Ashwagandha against human head and neck cancer cell lines
ConclusionsThese suggest that MEAG and WA may be potential natural materials for the treatment of HNSCC.
Source: Journal of Oral Pathology and Medicine - August 1, 2015 Category: Pathology Authors: Haeng‐Eun Lee, Ji‐Ae Shin, Joseph H. Jeong, Jae‐Gyu Jeon, Min‐Ho Lee, Sung‐Dae Cho Tags: Original Article Source Type: research

Plasminogen activator inhibitor‐1 as regulator of tumor‐initiating cell properties in head and neck cancers
ConclusionThe inhibition of PAI‐1 by PAI‐039 or siRNA could suppress head and neck cancer‐TICs within head and neck cancer cell lines through the downregulation of Sox2. © 2015 Wiley Periodicals, Inc. Head Neck, 2015
Source: Head and Neck - July 16, 2015 Category: ENT & OMF Authors: Yueh‐Chun Lee, Cheng‐Chia Yu, Chih Lan, Che‐Hsin Lee, Hsueh‐Te Lee, Yu‐Liang Kuo, Po‐Hui Wang, Wen‐Wei Chang Tags: Original Article Source Type: research

Abstract B05: PI3K/mTOR pathway-dependent regulation of oxygen metabolism via pyruvate dehydrogenase (PDH)-E1alpha phosphorylation
The PI3K/mTOR pathway plays a central role in coupling metabolic processes to the cellular proliferative state. In the current study we show that pharmacological inhibition of this pathway leads to a decrease in hypoxia within SQ20B human head and neck cancer xenografts. The mechanism underlying the effect appears in part to be due to reduced tumor cell oxygen consumption induced by the drug. Pharmacologic inhibitors of the PI3K/mTOR pathway or genetic inhibition of Akt/PI3K decreased the oxygen consumption rate (OCR) in transformed cell lines in vitro by 30-40%. Pharmacologic inhibition of this pathway increased phosphory...
Source: Molecular Cancer Therapeutics - July 6, 2015 Category: Cancer & Oncology Authors: Cerniglia, G., Dey, S., Gallagher-Colombo, S. M., Daurio, N., Tuttle, S., Busch, T. M., Lin, A., Esipova, T. V., Vinogradov, S., Koumenis, C., Maity, A. Tags: Downstream Effectors Underlying Cancer Progression: Poster Presentations - Proffered Abstracts Source Type: research

Plasminogen activator inhibitor‐1 regulates tumor initiating cell properties in head and neck cancers
Conclusion The inhibition of PAI‐1 by PAI‐039 or siRNA could suppress HNC‐TICs within HNC cell lines through the down‐regulation of Sox2. This article is protected by copyright. All rights reserved.
Source: Head and Neck - May 1, 2015 Category: ENT & OMF Authors: Yueh‐Chun Lee, Cheng‐Chia Yu, Chih Lan, Che‐Hsin Lee, Hsueh‐Te Lee, Yu‐Liang Kuo, Po‐Hui Wang, Wen‐Wei Chang Tags: Original Article Source Type: research

Energy Metabolism in a Matched Model of Radiation Resistance for Head and Neck Squamous Cell Cancer.
In this study, we investigated the reprogramming of the energy metabolism in radiosensitive and radioresistant head and neck squamous cell carcinomas (HNSCC) using a preclinical matched model of radiation resistance. Our investigation found that radioresistant rSCC-61 cells: 1. They display increased glucose uptake and decreased fatty acid uptake; 2. They deviate from the classical Warburg effect by diverting the glycolytic flux into the pentose phosphate pathway; 3. They are more dependent on glucose than glutamine metabolism to support growth; 4. They have decreased mitochondrial oxidative phosphorylation; 5. They have e...
Source: Radiation Research - March 4, 2015 Category: Physics Authors: Mims J, Bansal N, Bharadwaj MS, Chen X, Molina AJ, Tsang AW, Furdui CM Tags: Radiat Res Source Type: research

Abstract 596: DKK3 expression and its function in head and neck squamous cell carcinoma
In this study, 90 cases of HNSCC tissue samples, which were obtained from Okayama University hospital with written informed consent, for immunohistochemistry to examine DKK3 protein expression. The protein expression status was scored as positive or negative. Pearson's Chi-square test and Fisher's exact test were used to evaluate the correlation between the DKK3 protein expression and clinicopathological characteristics. Kaplan-Meier analysis was performed to determine the survival analysis. For functional analyses, HNSCC-derived cells were used. Gastric and colorectal cancer cell lines were also used for comparison. DKK3 ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Katase, N., Gunduz, M., Tsujigiwa, H., Ito, S., Fujii, M., Nagatsuka, H., Sasaki, A., Nohno, T. Tags: Molecular and Cellular Biology Source Type: research

Abstract 1925: CK2 phosphorylates and inhibits tumor suppressor TAp73 function to promote cancer stem cell gene expression and phenotype in head and neck cancer
Cancer development, cell survival, and therapeutic resistance have recently been linked to a small sub-population of cells expressing stem cell genes, and capable of reproducing the cancer cell population, called cancer stem cells (CSC). CK2 (formerly casein kinase II) has emerged as a key signal serine/threonine kinase that modulates diverse signal cascades that regulate cell fate and growth. We previously showed that CK2 is aberrantly expressed and activated in head and neck squamous cell carcinomas (HNSCC). Concomitant inactivation of tumor suppressor TAp73, along with mutation of related family member TP53, is also oft...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Lu, H., Yan, C. H., Bian, Y., Chen, Z., Waes, C. V. Tags: Tumor Biology Source Type: research