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Whole-genome sequencing of childhood cancer survivors treated with cranial radiation therapy identifies 5p15.33 locus for stroke: A report from the St. Jude Lifetime Cohort study.
CONCLUSIONS: A novel locus 5p15.33 is associated with stroke risk among childhood cancer survivors, with a possible CRT dose-specific effect. The locus is of potential clinical utility in characterizing individuals who may benefit from surveillance and intervention strategies. PMID: 31462438 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - August 27, 2019 Category: Cancer & Oncology Authors: Sapkota Y, Cheung YT, Moon W, Shelton K, Wilson CL, Wang Z, Mulrooney DA, Zhang J, Armstrong GT, Hudson MM, Robison LL, Krull KR, Yasui Y Tags: Clin Cancer Res Source Type: research

Survivors of childhood cancer have high-risk of recurrent stroke
(University of California - San Francisco) A new study from the UCSF Pediatric Brain Center shows that childhood cancer survivors suffering one stroke have double the risk of suffering a second stroke, when compared with non-cancer stroke survivors.
Source: EurekAlert! - Cancer - August 26, 2015 Category: Cancer & Oncology Source Type: news

Childhood Cancer Survivors Who’ve Had One Stroke at Risk of Second
Rate is double that of people without cancer who've lived through one stroke, study finds
Source: The Doctors Lounge - Oncology - August 26, 2015 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Cardiology, Neurology, Oncology, Pediatrics, News, Source Type: news

Childhood Cancer Survivors Who've Had One Stroke at Risk of Second
Rate is double that of people without cancer who've lived through one stroke, study finds
Source: Cancercompass News: Other Cancer - August 27, 2015 Category: Cancer & Oncology Source Type: news

Genetic variant linked to increased stroke risk in childhood cancer survivors treated with CRT
(American Association for Cancer Research) A common single nucleotide polymorphism (SNP) was associated with increased risk for developing stroke in childhood survivors who received cranial radiation therapy (CRT) for their primary cancer, according to results presented at the AACR Annual Meeting 2019, March 29-April 3.
Source: EurekAlert! - Cancer - April 2, 2019 Category: Cancer & Oncology Source Type: news

A Cross‐Sectional Cohort Study of Cerebrovascular Disease and Late Effects After Radiation Therapy for Craniopharyngioma
ConclusionsPatients with craniopharyngioma treated with RT have a high prevalence of stroke and vascular abnormalities, particularly those with low HDL and longer duration of time since RT. There is a trend to suggest that continual GH replacement may reduce the risk of stroke. These patients should undergo careful monitoring and aggressive modification of stroke risk factors.
Source: Pediatric Blood and Cancer - January 12, 2016 Category: Cancer & Oncology Authors: Andrea C. Lo, A. Fuchsia Howard, Alan Nichol, Haroon Hasan, Monty Martin, Manraj Heran, Karen Goddard Tags: Research Article Source Type: research

Prevalence of cardiovascular late sequelae in long ‐term survivors of childhood cancer: A systematic review and meta‐analysis
ConclusionThis review showed the vast range of cardiovascular late effects after childhood or adolescent cancer therapy. The differences between the papers prevented drawing a conclusive picture of the prevalence of cardiovascular late effects. Large cohort studies and better reporting are needed to improve the knowledge on this topic.
Source: Pediatric Blood and Cancer - February 16, 2017 Category: Cancer & Oncology Authors: Peter Scholz ‐Kreisel, Claudia Spix, Maria Blettner, Susan Eckerle, Jörg Faber, Philipp Wild, Hiltrud Merzenich, Ulrike Hennewig Tags: Research Article Source Type: research

Clinical events in a large prospective cohort of children with sickle cell disease in Nagpur, India: evidence against a milder clinical phenotype in India
ConclusionsSCD‐related complications are more frequent in Indian children than that observed in CSSCD. Further study is indicated to define SCD phenotype in India.
Source: Pediatric Blood and Cancer - June 9, 2016 Category: Cancer & Oncology Authors: Dipty Jain, Aishwarya Arjunan, Vijaya Sarathi, Harshwardhan Jain, Amol Bhandarwar, Marike Vuga, Lakshmanan Krishnamurti Tags: Research Article Source Type: research

Cancers, Vol. 15, Pages 3992: Long-Term Adverse Effects of Neck Radiotherapy in Childhood on the Carotid Arteries in Survivors of Hodgkin Lymphoma
Conclusions: Vascular changes in survivors of childhood Hodgkin lymphoma after neck RT seem to be long-term. Therefore, these patients may have an increased risk of stroke. We suggest refinement of international guidelines according to our results.
Source: Cancers - August 6, 2023 Category: Cancer & Oncology Authors: Matja ž Popit Marjan Zaletel Bojana Žvan Lorna Zadravec Zaletel Tags: Article Source Type: research

Treatment-related cardiotoxicity in survivors of childhood cancer
Nature Reviews Clinical Oncology 10, 697 (2013). doi:10.1038/nrclinonc.2013.195 Authors: Steven E. Lipshultz, Thomas R. Cochran, Vivian I. Franco & Tracie L. Miller Treatment advances and higher participation rates in clinical trials have rapidly increased the number of survivors of childhood cancer. However, chemotherapy and radiation treatments are cardiotoxic and can cause cardiomyopathy, conduction defects, myocardial infarction, hypertension, stroke, pulmonary oedema, dyspnoea and exercise intolerance later in life.
Source: Nature Clinical Practice Oncology - October 29, 2013 Category: Cancer & Oncology Authors: Steven E. LipshultzThomas R. CochranVivian I. FrancoTracie L. Miller Tags: Review Source Type: research

Cardiovascular Disease Among Survivors of Adult-Onset Cancer: A Community-Based Retrospective Cohort Study.
CONCLUSION: The magnitude of subsequent CVD risk varies according to cancer subtype and by the presence of CVRFs. Overall survival in survivors who develop CVD is poor, emphasizing the need for targeted prevention strategies for individuals at highest risk of developing CVD. PMID: 26834065 [PubMed - as supplied by publisher]
Source: Clinical Prostate Cancer - February 1, 2016 Category: Cancer & Oncology Authors: Armenian SH, Xu L, Ky B, Sun C, Farol LT, Pal SK, Douglas PS, Bhatia S, Chao C Tags: J Clin Oncol Source Type: research

Cardiovascular Disease Among Survivors of Adult-Onset Cancer: A Community-Based Retrospective Cohort Study Epidemiology
Conclusion The magnitude of subsequent CVD risk varies according to cancer subtype and by the presence of CVRFs. Overall survival in survivors who develop CVD is poor, emphasizing the need for targeted prevention strategies for individuals at highest risk of developing CVD.
Source: Journal of Clinical Oncology - March 22, 2016 Category: Cancer & Oncology Authors: Armenian, Xu, Ky, Sun, Farol, Pal, Douglas, Bhatia, Chao Tags: Population and observational studies (SEER, WHI observational, etc.) Epidemiology Source Type: research

The right to be forgotten: a change in access to insurance and loans after childhood cancer?
ConclusionThis study showed that the financial burden of cancer can extend decades after diagnosis.Implications for Cancer SurvivorsThanks to a 2016 law, French cancer survivors no longer have to disclose their cancer to insurers after a fixed number of years. This law will probably lessen the socioeconomic burden of cancer.
Source: Journal of Cancer Survivorship - January 26, 2017 Category: Cancer & Oncology Source Type: research

The management of childhood cancer survivors at risk for stroke: A Delphi survey of regional experts
Pediatric Blood&Cancer, EarlyView.
Source: Pediatric Blood and Cancer - August 10, 2018 Category: Cancer & Oncology Authors: Lisa B.Kenney , BethanyAmes , Alexis L.Michaud , David N.Williams , Peter E.Manley , Nicole J.Ullrich Source Type: research

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