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Sex Differences in IL-33-Induced STAT6-Dependent Type 2 Airway Inflammation
In this study, we have demonstrated that delivery of OVA+IL-33 to the lungs of mice induced an innate inflammatory response that exhibited sex-dependent differences in magnitude and regulation. Compared to males, female mice produced larger amounts of type 2 cytokines and chemokines and had substantially more activated eosinophils and AAM in the lung; each of these responses was significantly lower in female mice lacking STAT6. On the contrary, male mice displayed less inflammation overall, and in some instances, no apparent role for STAT6 was observed. BALF levels of inflammatory mediators and eosinophils were very lo...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

Residential Air Pollution and Associations with Wheeze and Shortness of Breath in Adults: A Combined Analysis of Cross-Sectional Data from Two Large European Cohorts
Conclusion: Exposure to PM and NO2 air pollution was associated with the prevalence of wheeze and shortness of breath in this large study, with stronger associations between PM2.5 and both outcomes among lower- versus higher-income participants. https://doi.org/10.1289/EHP1353 Received: 13 November 2016 Revised: 10 August 2017 Accepted: 14 August 2017 Published: 29 September 2017 Address correspondence to D. Doiron, Research Institute of the McGill University Health Centre, 2155 rue Guy, office 458, Montreal, Canada, H3H 2R9. Telephone: 1-514-934-1934 (ex. 71688). Email: ddoiron@maelstrom-research.org Supplemental Ma...
Source: EHP Research - September 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Cochrane Skin Group celebrate 20 years of improving treatment of skin diseases
World-leading dermatologists and their patients are celebrating huge improvements in the treatment of skin diseases like skin cancer, psoriasis, and acne as theCochrane Skin Group marks its 20th anniversary this week.   The effects of the 120 plus published Cochrane Skin Reviews have been far-reaching and have had real impacts on patient care. These include skin cancer, skin allergies, and acne, blistering diseases, hair disorders like alopecia, fungal infections and psoriasis as well as tropical parasitic disea ses.The group is coordinated by the University of Nottingham ’s Centre of Evidence Based Dermatology and is p...
Source: Cochrane News and Events - September 12, 2017 Category: Information Technology Authors: Muriah Umoquit Source Type: news

Updated Global Estimates of Respiratory Mortality in Adults ≥ 30 Years of Age Attributable to Long-Term Ozone Exposure
Conclusions: These findings suggest that the potential magnitude of health benefits of air quality policies targeting O3, health co-benefits of climate mitigation policies, and health implications of climate change-driven changes in O3 concentrations, are larger than previously thought. https://doi.org/10.1289/EHP1390 Received: 17 November 2016 Revised: 19 June 2017 Accepted: 20 June 2017 Published: 28 August 2017 Address correspondence to C.S. Malley, Stockholm Environment Institute, Environment Dept., Environment Building, Wentworth Way, University of York, York, YO10 5NG, UK. Telephone: 44 1904 323685. Email: chri...
Source: EHP Research - August 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Elemental Sulfur Use and Associations with Pediatric Lung Function and Respiratory Symptoms in an Agricultural Community (California, USA)
Conclusions: This study suggests that elemental sulfur use, allowed in both organic and conventional farming, in close proximity to residential areas, may adversely affect children’s respiratory health. https://doi.org/10.1289/EHP528 Received: 19 May 2016 Revised: 05 May 2017 Accepted: 09 May 2017 Published: 14 August 2017 Address correspondence to R. Raanan, Center for Environmental Research and Children’s Health (CERCH), University of California, Berkeley, School of Public Health, 1995 University Ave., Suite 265, Berkeley, CA 94704 USA. Telephone: (510) 642-9431. Email: rachelraananrr@gmail.com Supplemental Ma...
Source: EHP Research - August 14, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Nature Contact and Human Health: A Research Agenda
Conclusions: Nature contact may offer a range of human health benefits. Although much evidence is already available, much remains unknown. A robust research effort, guided by a focus on key unanswered questions, has the potential to yield high-impact, consequential public health insights. https://doi.org/10.1289/EHP1663 Received: 26 January 2017 Revised: 12 May 2017 Accepted: 25 May 2017 Published: 31 July 2017 Address correspondence to H. Frumkin, Dept. of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Box 354695, Seattle, WA 98195-4695 USA; Telephone: 206-897-1723;...
Source: EHP Research - July 31, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

Exposure to Traffic-Related Air Pollution and Serum Inflammatory Cytokines in Children
Conclusion: Our results indicate alterations in systemic inflammatory markers in 8-y-old children in relation to early-life exposure to traffic-related air pollution. https://doi.org/10.1289/EHP460 Received: 04 May 2016 Revised: 20 October 2016 Accepted: 07 November 2016 Published: 16 June 2017 Address correspondence to O. Gruzieva, Karolinska Institutet, Institute of Environmental Medicine, Nobels väg 13 Box 210, SE-17177, Stockholm, Sweden. Telephone: 46 8 524 80022. Fax: 46 8 304571. E-mail: olena.gruzieva@ki.se Supplemental Material is available online (https://doi.org/10.1289/EHP460). The authors declare they h...
Source: EHP Research - June 16, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

Humoral Immunity in Arsenic-Exposed Children in Rural Bangladesh: Total Immunoglobulins and Vaccine-Specific Antibodies
Conclusions: Arsenic exposure increased tIgG and tIgE in plasma, and tended to decrease mumps-specific IgG in children at 9 years of age. https://doi.org/10.1289/EHP318 Received: 09 April 2016 Revised: 09 October 2016 Accepted: 24 October 2016 Published: 14 June 2017 Address correspondence to R. Raqib, Immunobiology, Nutrition and Toxicology Laboratory, Infectious Diseases Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka-1212, Bangladesh. Telephone: 880-2-9827068. E-mail: rubhana@icddrb.org Supplemental Material is available online (https://doi.org/10.1289/EHP318). The authors declare they have n...
Source: EHP Research - June 15, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

Racial and Ethnic Disparities in Research Studies: The Challenge of Creating More Diverse Cohorts
This reporting project was funded through a grant provided by the Reporting Award at New York University’s Arthur L. Carter Journalism Institute. Background image: Bahri Altay/Shutterstock About This Article open Citation: Konkel L. 2015. Racial and ethnic disparities in research studies: the challenge of creating more diverse cohorts. Environ Health Perspect 123:A297–A302; http://dx.doi.org/10.1289/ehp.123-A297 Published: 1 December 2015 PDF Version (873 KB) Minority populations are much less likely than their white counterparts to be included in studies on environmentally related diseases, even t...
Source: EHP Research - December 1, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured News Spheres of Influence December 2015 Source Type: research