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Cancer: Non-Small Cell Lung Cancer
Drug: Acetylcysteine
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Total 18 results found since Jan 2013.
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer
Eur J Pharmacol. 2023 Aug 23:176004. doi: 10.1016/j.ejphar.2023.176004. Online ahead of print.ABSTRACTSmall molecule drugs are of significant importance in the treatment of non-small cell lung cancer (NSCLC). Here, we explored biological effects of the PI3K/mTOR inhibitor VS-5584 on NSCLC. Our findings indicated that VS-5584 administration resulted in a dose-dependent inhibition of NSCLC cell proliferation, as well as the induction of apoptosis and cycle arrest. Additionally, we observed a significant increase in intracellular reactive oxygen species (ROS) levels following VS-5584 treatment. The use of the ROS inhibitor N-...
Source: European Journal of Pharmacology - August 25, 2023 Category: Drugs & Pharmacology Authors: Senxia Zhao Yibin Li Gang Li Juanping Ye Rong Wang Xiaoting Zhang Fei Li Chang Gao Junbiao Li Jie Jiang Yanjun Mi Source Type: research
Pendulone induces apoptosis via the ROS-mediated ER-stress pathway in human non-small cell lung cancer cells
CONCLUSION: Our findings provide evidence that pendulone induces apoptosis by inducing ER stress through ROS accumulation and mitochondrial dysfunction in NSCLC cell lines.PMID:35288263 | DOI:10.1016/j.tiv.2022.105346
Source: Toxicology in Vitro - March 15, 2022 Category: Toxicology Authors: Wen-Chien Cheng Ya Wen Yen-Shuo Chiu Chia-Hao Chou Chen-Jen Lim Sheng-Hao Lin Jia-Ming Chang Chi-Chien Lin Source Type: research
Arsenite-induced cytotoxicity is regulated by p38-SQSTM1/p62 and JNK-BNIP3L/Nix signaling in lung cancer cells
Biochem Biophys Res Commun. 2021 Nov 26;587:16-23. doi: 10.1016/j.bbrc.2021.11.068. Online ahead of print.ABSTRACTArsenic is a potent carcinogen in humans. However, the molecular mechanisms underlying its toxicity in lung cancer remain unclear. Here, we report that arsenite-induced cytotoxicity is regulated by SQSTM1/p62 and BNIP3L/Nix signaling in non-small-cell lung cancer H460 cells. Arsenite exposure resulted in dose-dependent growth inhibition, which was associated with apoptosis, as demonstrated by depolarized mitochondrial membrane potential and cleavage of caspase-8, caspase-3, PARP-1, and Bax. The autophagy adapto...
Source: Biochemical and Biophysical Research communications - December 3, 2021 Category: Biochemistry Authors: Hyun-Young Lee Seon-Hee Oh Source Type: research
Raddeanin A induced apoptosis of non-small cell lung cancer cells by promoting ROS-mediated STAT3 inactivation
CONCLUSION: Raddeanin A suppressed the proliferation and induced apoptosis of NSCLC cells via promoting the ROS-mediated STAT3 inactivation.PMID:34146943 | DOI:10.1016/j.tice.2021.101577
Source: Tissue and Cell - June 19, 2021 Category: Cytology Authors: Liang Li Minbiao Chen Gao Li Renzhong Cai Source Type: research
Aloe-emodin induces autophagy and apoptotic cell death in non-small cell lung cancer cells via Akt/mTOR and MAPK signaling.
In this study, the bioassay results demonstrated that AE reduced the viability of the non-small cell lung cancer cell line A549 and NCI-H1299 in a dose- and time-dependent manner. Moreover, AE induced caspase-dependent apoptosis and autophagy. AE induced autophagy through activation of MAPK signaling and inhibition of the Akt/mTOR pathway. We also found that AE-induced autophagy was attenuated by the reactive oxygen species scavenger N-acetylcysteine, indicating that reactive oxygen species played a key role in AE-mediated autophagy in A549 and NCI-H1299 cells. Furthermore, AE induced reactive oxygen species-dependent au...
Source: European Journal of Pharmacology - September 10, 2020 Category: Drugs & Pharmacology Authors: Shen F, Ge C, Yuan P Tags: Eur J Pharmacol Source Type: research
Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling
In this study, we aimed to investigate the potential anti-proliferative and pro-apoptotic activities of SNG in a panel of MM cell lines (U266, IM9, MM1S, and RPMI-8226). SNG treatment of MM cells resulted in a dose-dependent decrease in cell viability through mitochondrial membrane potential loss and activation of caspase 3, 9, and cleavage of PARP. Pre-treatment of MM cells with a universal caspase inhibitor, Z-VAD-FMK, prevented SNG mediated loss of cell viability, apoptosis, and caspase activation, confirming that SNG-mediated apoptosis is caspase-dependent. The SNG-mediated apoptosis appears to be resulted from suppres...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research
