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Travel vaccines are strongly associated to reduced mortality in prostate cancer patients - a real effect or residual confounding?
Vaccine. 2022 May 21:S0264-410X(22)00611-9. doi: 10.1016/j.vaccine.2022.05.028. Online ahead of print.ABSTRACTRepurposing of existing drugs and vaccines for diseases that they were not originally intended for is a promising research field. Recently there has been evidence that oral cholera vaccine might be used in the treatment of inflammatory disease and some common cancers. Specifically, Ji et al showed that the administration of cholera vaccine after a prostate cancer diagnosis reduced prostate cancer specific mortality rates by almost 50%. In a cohort of men from Stockholm, Sweden, with more detailed cancer data and a ...
Source: Vaccine - May 24, 2022 Category: Allergy & Immunology Authors: Axel M öller Klaus Schwamborn Adrian Spillmann Janet Hoogstraate Robert Szulkin Olof Akre Lars Egevad Mark Clements Markus Aly Source Type: research

All Your Coronavirus Questions, Answered
One of the worst symptoms of any plague is uncertainty—who it will strike, when it will end, why it began. Merely understanding a pandemic does not stop it, but an informed public can help curb its impact and slow its spread. It can also provide a certain ease of mind in a decidedly uneasy time. Here are some of the most frequently asked questions about the COVID-19 pandemic from TIME’s readers, along with the best and most current answers science can provide. A note about our sourcing: While there are many, many studies underway investigating COVID-19 and SARS-CoV-19, the novel coronavirus that causes the illn...
Source: TIME: Health - April 14, 2020 Category: Consumer Health News Authors: TIME Staff Tags: Uncategorized COVID-19 Explainer Source Type: news

Fight Aging! Newsletter, January 20th 2020
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role is t...
Source: Fight Aging! - January 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

An Animal Model of Acute and Chronic Chagas Disease With the Reticulotropic Y Strain of Trypanosoma cruzi That Depicts the Multifunctionality and Dysfunctionality of T Cells
In conclusion, during acute T. cruzi infection with the reticulotropic Y strain, immune activation leads to the generation of antigen-specific multifunctional CD4+ Th1 and CD8+ Tc1 cells and their regulation by inhibitory receptor co-expression. In contrast, during chronic T. cruzi infection, the chronicity of the infection induces a moderate inflammatory infiltrate in colon and liver tissues accompanied with poor T cell effector function that is possibly related to the co-expression of inhibitory receptors on T cells, but this phenomenon does not occur in cytotoxic CD8+ T cells. Taken together, these data supp...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research