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Fight Aging! Newsletter, August 8th 2022
In conclusion, aging research will benefit from a better definition of how specific regulators map onto age-dependent change, considered on a phenotype-by-phenotype basis. Resolving some of these key questions will shed more light on how tractable (or intractable) the biology of aging is. Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes? https://www.fightaging.org/archives/2022/08/does-acarbose-extend-life-in-short-lived-species-via-gut-microbiome-changes/ Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a ...
Source: Fight Aging! - August 7, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
August 04, 2022 Edition-----The war seems to grind on sadly and Pres. Biden is having a second round with COVID as unprecedented weather happens all over the US. It all feels rather like ‘the end of days’!In the UK we see an increasing chance of a third female PM being elected as the country seems to be struggling. We do need to remember however the UK remains a significant power with nuclear weapons and home-grown nuclear submarines!In OZ we have had last week working out how to progress the First Nations ‘Voice’ as we wrap up the 1st session of Parliament for the new Government. Comments welcome on how you think ...
Source: Australian Health Information Technology - August 4, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Exposome and Skin. Part 2. The Influential Role of the Exposome, Beyond UVR, in Actinic Keratosis, Bowen ’s Disease and Squamous Cell Carcinoma: A Proposal
AbstractActinic keratosis (AK) is the main risk factor for the development of cutaneous invasive squamous cell carcinoma (SCC). It represents the first sign of severe chronic ultraviolet radiation exposure, which has a clear significant effect. Nevertheless, the skin is exposed to many other exposome factors which should be thoroughly considered. Our aim was to assess the impact of exposome factors other than ultraviolet radiation (UVR) on the etiopathology of AK and Bowen ’s disease (BD) and progression of AK to SCC and to design tailored prevention strategies. We performed an exhaustive literature search in September 2...
Source: Dermatology and Therapy - February 3, 2022 Category: Dermatology Source Type: research

Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, November 8th 2021
In conclusion, in less common and visible cardiovascular diseases, it is crucial to recognize substantial progress and achievement, given that penetration of such information into clinical practice and the patient community can be inconsistent. Diseases such as hypertrophic cardiomyopathy, pulmonary arterial hypertension, and ATTR cardiac amyloidosis, once linked to a uniformly adverse prognosis, are now associated with the opportunity for patients to experience satisfactory quality of life and extended longevity. VitaDAO, a Novel Approach to Crowdfunding Life Science Research https://www.fightaging.org/archive...
Source: Fight Aging! - November 7, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Evaluating the Impact of the U.S. National Toxicology Program: A Case Study on Hexavalent Chromium
Conclusions: This study identified a broad and objective approach for assessing NTP’s effectiveness, including methodological needs for more thorough and efficient impact assessments in the future. Citation: Xie Y, Holmgren S, Andrews DMK, Wolfe MS. 2017. Evaluating the impact of the U.S. National Toxicology Program: a case study on hexavalent chromium. Environ Health Perspect 125:181–188; http://dx.doi.org/10.1289/EHP21 Address correspondence to Y. Xie, National Institute of Environmental Health Sciences, P.O. Box 12233, Mail Drop K2-03, Research Triangle Park, NC 27709 USA. Express mail address: 530 Davis Dr., Room...
Source: EHP Research - February 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles February 2017 Source Type: research

Moving out of academia: rethink and reshape your skills
For those transitioning from academia to non-academic jobs, the fear of not getting hired due to a lack of skills or experience can be very real. However, scientists have many transferrable skills that are highly sought after by various companies. For example, postdocs are essentially mini project managers – they design and implement experiments, manage students and collaborators, set timelines and schedules, keep projects within budget, organize data in presentable formats, and routinely meet deadlines. Although we may not view these mundane tasks as ‘skills’ per se, in the broader picture, they are skills. Specific...
Source: BioMed Central Blog - December 21, 2015 Category: Journals (General) Authors: Victoria Schulman Tags: Biology Health Medicine career exploration Source Type: blogs