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Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Exploring Cardiac Impact of Oral Nicotine Exposure in a Transplantable Neoplasm Mice Model: Insights from Biochemical Analysis, Morphometry, and Molecular Docking: Chlorella vulgaris Green Algae Support
This study was designed to investigate the impact of nicotine and Chlorella vulgaris (Ch. V) on cardiac glutathione homeostasis, inflammatory response, cardiac damage markers, apoptotic proteins and histopathological findings in an experimentally transplantable neoplasm mouse model (Ehrlich ascites carcinoma; EAC). In the in-vivo experiment, the female Swiss mice were divided into four groups: control, Ch.V (100mg/kg), Nicotine (100µg/ml/kg), and a combination group ( Nocotine+ Ch.V) for 40 days. Furthermore, the effects of C. vulgaris components on caspase-3, TNF-α, and IL-1β activity were explored using Molecular Oper...
Source: Toxicology - September 13, 2023 Category: Toxicology Authors: Amany Abdel-Rahman Mohamed Gihan G Moustafa Khlood M El Bohy Taghred M Saber Mohamed M M Metwally Heba El Desoukey Mohammed Ali H El-Far Badriyah S Alotaibi Manal Alosaimi Samah S Abuzahrah Leena S Alqahtani Source Type: research

Oral nicotine pouches with an aftertaste? Part 1: screening and initial toxicological assessment of flavorings and other ingredients
Arch Toxicol. 2023 Jun 30. doi: 10.1007/s00204-023-03538-9. Online ahead of print.ABSTRACTNicotine pouches are oral products that deliver nicotine without containing tobacco. Previous studies mainly focused on the determination of known tobacco toxicants, while yet no untargeted analysis has been published on unknown constituents, possibly contributing to toxicity. Furthermore, additives might enhance product attractiveness. We therefore performed an aroma screening with 48 different nicotine-containing and two nicotine-free pouches using gas chromatography coupled to mass spectrometry, following acidic and basic liquid-li...
Source: Archives of Toxicology - June 30, 2023 Category: Toxicology Authors: Nadja Mallock-Ohnesorg Selina Rinaldi Sebastian Malke Nadine Dreiack Elke Pieper Peter Laux Thomas Schulz Ralf Zimmermann Andreas Luch Source Type: research

The risk profile of electronic nicotine delivery systems, compared to traditional cigarettes, on oral disease: a review
Front Public Health. 2023 May 15;11:1146949. doi: 10.3389/fpubh.2023.1146949. eCollection 2023.ABSTRACTThe use of electronic nicotine delivery systems (ENDS) has exploded, especially among teenagers and new smokers, amid widespread awareness of the dangers of traditional tobacco and restrictions on smoking. However, the risk effects of ENDS on physical health, especially oral health, are still ambiguous. The purpose of this study was to review the available evidence on risks of ENDS on oral health, and compares the differences between ENDS and traditional cigarettes. For heavy smokers, transferring the addiction of tobacco...
Source: Cancer Control - May 31, 2023 Category: Cancer & Oncology Authors: Qing Zhang Cai Wen Source Type: research

Effect of educational intervention based on theory of planned behaviour on promoting preventive behaviours of oral cancer in rural women
CONCLUSION: Due to the alarming situation of oral cancer and the prevalence of hookah use among women, educational programs based on TPB could effectively prevent hookah use and oral cancer.PMID:37161434 | DOI:10.1186/s12905-023-02411-2
Source: Cancer Control - May 10, 2023 Category: Cancer & Oncology Authors: Siamak Najafi Fatemeh Mohammadkhah Pooyan Afzali Harsini Mojtaba Sohrabpour Ali Khani Jeihooni Source Type: research

Interactions of Betel Quid Constituents with Drug Disposition Pathways: An Overview
Curr Drug Metab. 2023 Feb 28. doi: 10.2174/1389200224666230228142052. Online ahead of print.ABSTRACTGlobal estimates indicate that over 600 million individuals worldwide consume the areca (betel) nut in some form. Nonetheless, its consumption is associated with a myriad of oral and systemic ailments, such as pre-cancerous oral lesions, oropharyngeal cancers, liver toxicity and hepatic carcinoma, cardiovascular distress, and addiction. Users commonly chew sliver nuts in a complex consumable preparation called betel quid (BQ). Consequently, the user is exposed to a wide array of chemicals with diverse pharmacokinetic behavio...
Source: Current Drug Metabolism - February 28, 2023 Category: Drugs & Pharmacology Authors: Jasmine Canlas Alan L Myers Source Type: research