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Systems Pharmacology-Based Identification of Mechanisms of Action of Bolbostemma paniculatum for the Treatment of Hepatocellular Carcinoma.
CONCLUSIONS The PI3K/Akt, HIF1, p53, and PPAR pathways may play vital roles in TBM treatment of HCC. Also, the potential anti-cancer effect of TBM on HCC appears to stem from the synergetic effect of multiple targets and mechanisms. PMID: 33436534 [PubMed - in process]
Source: Medical Science Monitor - January 15, 2021 Category: Research Tags: Med Sci Monit Source Type: research

System-Wide Pollution of Biomedical Data: Consequence of the Search for Hub Genes of Hepatocellular Carcinoma Without Spatiotemporal Consideration
AbstractBiomedical institutions rely on data evaluation and are turning into data factories. Big-data storage centers, supercomputing systems, and increased algorithmic efficiency allow us to analyze the ever-increasing amount of data generated every day in biomedical research centers. In network science, the principal intrinsic problem is how to integrate the data and information from different experiments on genes or proteins. Data curation is an essential process in annotating new functional data to known genes or proteins, undertaken by a biobank curator, which is then reflected in the calculated networks. We provide a...
Source: Molecular Diagnosis and Therapy - January 21, 2021 Category: Molecular Biology Source Type: research

The value of preoperative systemic immune-inflammation index in predicting vascular invasion of hepatocellular carcinoma: a meta-analysis
Braz J Med Biol Res. 2021 Feb 26;54(4):e10273. doi: 10.1590/1414-431X202010273. eCollection 2021.ABSTRACTVascular invasion and systemic immune-inflammation index (SII) are risk factors for the prognosis of patients with hepatocellular carcinoma. At present, the correlation between the two is not clear. This meta-analysis explored the relationship between preoperative SII and vascular invasion in patients with hepatocellular carcinoma. According to the search formula, the Pubmed, Embase, Cochrane, Web of Science, and CNKI databases were searched for the relevant research until March 2020. After the quality evaluation of the...
Source: Brazilian Journal of Medical and Biological Research - March 3, 2021 Category: Research Authors: YiFeng Wu ChaoYong Tu ChuXiao Shao Source Type: research

Stereotactic ablative radiotherapy for hepatocellular carcinoma: A systematic review and meta ‐analysis of local control, survival and toxicity outcomes
SummaryThere is a growing body of literature supporting the use of stereotactic ablative body radiotherapy (SABR) in the management of primary hepatocellular carcinoma (HCC). This systematic review and meta-analysis of the current published evidence for SABR for HCC assessed the impact of treatment dose, fractionation and tumour size on the outcomes of local control (LC), overall survival (OS) and toxicity. A systematic search was independently performed by two authors for articles published in peer-reviewed journals between January 2005 and December 2019. A DerSimonian and Laird random effects model was used to assess poo...
Source: Journal of Medical Imaging and Radiation Oncology - August 16, 2021 Category: Radiology Authors: Mihir D. Shanker, Pereshin Moodaley, Wei Soon, Howard Y. Liu, Yoo Young Lee, David I. Pryor Tags: Radiation Oncology —Review Article Source Type: research

Retraction Note: LINC01296 promotes the proliferation and invasion by regulating microRNA-760 expression and predicts poor prognosis of hepatocellular carcinoma
Eur Rev Med Pharmacol Sci. 2023 Jan;27(2):442. doi: 10.26355/eurrev_202301_31042.ABSTRACTThe article "LINC01296 promotes the proliferation and invasion by regulating microRNA-760 expression and predicts poor prognosis of hepatocellular carcinoma", by Z.-C. Wang, S. Yang, M.-Q. Chen, S.-S. Wu, H.-H. Lv, W.-X. Jin, published in Eur Rev Med Pharmacol Sci 2019; 23 (22): 9848-9856-DOI: 10.26355/eurrev_201911_19548- PMID: 31799652 has been retracted by the author for the following reasons: After the publication of this article, the authors reviewed the process of the experiment and found there were mistakes in the methodology se...
Source: European Review for Medical and Pharmacological Sciences - February 3, 2023 Category: Drugs & Pharmacology Authors: Z-C Wang S Yang M-Q Chen S-S Wu H-H Lv W-X Jin Source Type: research