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Condition: Diabetes
Cancer: Liver Cancer
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Total 698 results found since Jan 2013.
Canagliflozin reduces chemoresistance in hepatocellular carcinoma through PKM2-c-Myc complex-mediated glutamine starvation
In conclusion, our study showed that CANA re-sensitized HCC to CPT by inducing ferroptosis through dual effects on glycolysis and glutamine metabolism. This is a novel mechanism to increase chemosensitivity, which may provide compatible chemotherapy drugs for HCC.PMID:37696420 | DOI:10.1016/j.freeradbiomed.2023.09.006
Source: Free Radical Biology and Medicine - September 11, 2023 Category: Biology Authors: Yuan Zeng Haoran Jiang Xiangting Zhang Jun Xu Xiao Wu Qian Xu Weimin Cai Huiya Ying Ruoru Zhou Yingrong Ding Kanglei Ying Xian Song Zhuoyan Chen Liuwei Zeng Luying Zhao Fujun Yu Source Type: research
Tartary buckwheat root polysaccharides ameliorate non-alcoholic fatty liver disease via the IL6-SOCS3-SREBP1c pathway
Food Chem Toxicol. 2023 Aug 19:113997. doi: 10.1016/j.fct.2023.113997. Online ahead of print.ABSTRACTOur previous study demonstrated that Tartary buckwheat root polysaccharides (TBRP) could reduce insulin resistance in diabetes mellitus by inhibiting SOCS3-stimulated IRS1 protein degradation. However, whether TBRP has the efficiency to treat non-alcoholic fatty liver disease (NAFLD) is still undetermined. This investigation aimed to examine the effects of TBRP on a high-fat diet (HFD)-triggered NAFLD, and elucidate the underlying molecular mechanisms. Briefly, TBRP toxicity in hepatoma (BEL7404) and pancreatic cancer (BxPC...
Source: Food and Chemical Toxicology - August 21, 2023 Category: Food Science Authors: Litao Zhang Shuo Wang Yimin Li Boyu Liu Zeyu Duan Fei Liu Qiang Ren Source Type: research
Serum resistin and the risk for hepatocellular carcinoma in diabetic patients
This article aims to examine the existing literature on the possible use of resistin levels as a biomarker for HCC development and monitoring. Furthermore, it reviews the possible pathways of HCC initiation due to elevated resistin and offers new perspectives on comprehending the fundamental mechanisms of HCC in diabetic patients. Gaining a better understanding of these processes may yield valuable insights into HCC's development and progression, as well as identify possible avenues for prevention and therapy.PMID:37545641 | PMC:PMC10401662 | DOI:10.3748/wjg.v29.i27.4271
Source: World Journal of Gastroenterology : WJG - August 7, 2023 Category: Gastroenterology Authors: Mona Mohamed Ibrahim Abdalla Source Type: research
Synthesis and potential antidiabetic and lipid-lowering activities of putative asperidine B and its desmethyl analogue
Bioorg Med Chem Lett. 2023 Aug 6;93:129437. doi: 10.1016/j.bmcl.2023.129437. Online ahead of print.ABSTRACTPutative asperidine B is an unnatural 2,6-disubstituted piperidin-3-ol and a structural isomer of (+)-preussin, a well-known pyrrolidin-3-ol alkaloid. This work reports the first enantioselective synthesis of putative asperidine B and its desmethyl analogue via a chiron approach starting from d-isoascorbic acid as well as evaluation of their free-radical scavenging, antidiabetic, and anti-hyperlipidemic activities. Both putative asperidine B and its desmethyl analogue markedly reduced the total reactive oxygen species...
Source: Bioorganic and Medicinal Chemistry Letters - August 7, 2023 Category: Chemistry Authors: Kittisak Thongpat Pannita Holasut Atcharaporn Ontawong Jakkapong Inchai Acharaporn Duangjai Vatcharin Rukachaisirikul Chutima S Vaddhanaphuti Kwanruthai Tadpetch Source Type: research
Serum resistin and the risk for hepatocellular carcinoma in diabetic patients
This article aims to examine the existing literature on the possible use of resistin levels as a biomarker for HCC development and monitoring. Furthermore, it reviews the possible pathways of HCC initiation due to elevated resistin and offers new perspectives on comprehending the fundamental mechanisms of HCC in diabetic patients. Gaining a better understanding of these processes may yield valuable insights into HCC's development and progression, as well as identify possible avenues for prevention and therapy.PMID:37545641 | PMC:PMC10401662 | DOI:10.3748/wjg.v29.i27.4271
Source: World Journal of Gastroenterology - August 7, 2023 Category: Gastroenterology Authors: Mona Mohamed Ibrahim Abdalla Source Type: research
Synthesis and potential antidiabetic and lipid-lowering activities of putative asperidine B and its desmethyl analogue
Bioorg Med Chem Lett. 2023 Aug 5:129437. doi: 10.1016/j.bmcl.2023.129437. Online ahead of print.ABSTRACTPutative asperidine B is an unnatural 2,6-disubstituted piperidin-3-ol and a structural isomer of (+)-preussin, a well-known pyrrolidin-3-ol alkaloid. This work reports the first enantioselective synthesis of putative asperidine B and its desmethyl analogue via a chiron approach starting from D-isoascorbic acid as well as evaluation of their free-radical scavenging, antidiabetic, and anti-hyperlipidemic activities. Both putative asperidine B and its desmethyl analogue markedly reduced the total reactive oxygen species (R...
Source: Bioorganic and Medicinal Chemistry Letters - August 7, 2023 Category: Chemistry Authors: Kittisak Thongpat Pannita Holasut Atcharaporn Ontawong Jakkapong Inchai Acharaporn Duangjai Vatcharin Rukachaisirikul Chutima S Vaddhanaphuti Kwanruthai Tadpetch Source Type: research
Serum resistin and the risk for hepatocellular carcinoma in diabetic patients
This article aims to examine the existing literature on the possible use of resistin levels as a biomarker for HCC development and monitoring. Furthermore, it reviews the possible pathways of HCC initiation due to elevated resistin and offers new perspectives on comprehending the fundamental mechanisms of HCC in diabetic patients. Gaining a better understanding of these processes may yield valuable insights into HCC's development and progression, as well as identify possible avenues for prevention and therapy.PMID:37545641 | PMC:PMC10401662 | DOI:10.3748/wjg.v29.i27.4271
Source: World Journal of Gastroenterology - August 7, 2023 Category: Gastroenterology Authors: Mona Mohamed Ibrahim Abdalla Source Type: research
