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Diagnosis and Therapy of Anal Carcinoma
Praxis (Bern 1994). 2022 Feb;110(2):89-96. doi: 10.1024/1661-8157/a003804.ABSTRACTDiagnosis and Therapy of Anal Carcinoma Summary. The squamous cell carcinoma of the anorectum is rare and subdivided into perianal, anal canal and combined carcinomas. Persistent infection with a high-risk human papillomavirus (HPV) is believed to be the main cause for the development of anal cancer. Therefore, the incidence in high-risk individuals (e.g. immuno-compromised patients or patients living with HIV) is much higher than in the general population. Nevertheless, a nearly three-fold overall increase was observed within the last three ...
Source: Praxis - February 2, 2022 Category: General Medicine Authors: Alexander Radke J örg Beyer Source Type: research

Case Report: Intra-Tumoral Vaccinations of Quadrivalent HPV-L1 Peptide Vaccine With Topical TLR-7 Agonist Following Recurrence: Complete Resolution of HPV-HR-Associated Gynecologic Squamous Cell Carcinomas in Two Patients
Pathol Oncol Res. 2021 Dec 20;27:1609922. doi: 10.3389/pore.2021.1609922. eCollection 2021.ABSTRACTThe human papilloma virus (HPV) high-risk variants (HPV-HR) such as HPV16 and HPV18 are responsible for most HPV related cancers, including anogenital and head and neck cancers. Here, we present two patients with HPV-HR-associated gynecological malignancies who, after failing radiation therapy, were treated with experimental salvage immunotherapy regimen resulting in complete, durable responses in both patients. Each patient was diagnosed with recurrent, radiation-refractory, HPV-HR positive, squamous cell carcinoma of the lo...
Source: Pathology Oncology Research - January 6, 2022 Category: Pathology Authors: Mark Reedy Shirisha Jonnalagadda Komaraiah Palle Source Type: research

The Prevalence of Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma at One of the Largest Tertiary Care Centers in Sub-Saharan Africa
CONCLUSIONS.—: The presence of high-risk HPV in 5% of cases suggests that high-risk HPV is a minor etiologic agent in oropharyngeal squamous cell carcinoma in this region. Given its suboptimal positive predictive value, p16 is not a reliable marker for high-risk HPV infection in this region. When p16 is positive, HPV-specific testing is necessary. The identification of less common high-risk HPV types, HPV-52 and HPV-31, may influence current local vaccination strategies.PMID:34871360 | DOI:10.5858/arpa.2021-0021-OA
Source: Archives of Pathology and Laboratory Medicine - December 6, 2021 Category: Laboratory Medicine Authors: Gloria Dapaah Jos Hille William C Faquin Judith Whittaker Corneli M Dittrich Abdul-Kader Ebrahim Johann W Schneider Abraham C van Wyk Johan Opperman Marc Merven Komeela Naidoo James W Loock Amir H Afrogheh Source Type: research

Double Positivity for HPV DNA/P16(INK4a) Does Not Influence Survival of Patients With Oral Squamous Cell Carcinoma
CONCLUSION: In contrast to oropharyngeal cancer, the prevalence of HPV in OSCC is low and the presence of HPV does not influence survival outcomes. Hence, there is no evidence to support a parallel transfer of therapy regimen for HPV-positive OPC to OSCC, in terms of therapy de-escalation and/or vaccination.PMID:34732426 | DOI:10.21873/anticanres.15369
Source: Cell Research - November 4, 2021 Category: Cytology Authors: Ubai Alsharif Marvin Hofmann Maximilian Gebhard Lars Tharun Dirk Rades Peter Sieg Samer G Hakim Source Type: research

Association between systemic lupus erythematosus and risk of cervical atypia: A meta-analysis
CONCLUSION: In summary, findings of this meta-analysis demonstrated that SLE was associated with a higher risk of cervical pre-malignant lesions and carcinoma. It may be necessary for clinicians to remind women with SLE to screen human papillomavirus infection and be vaccinated as soon as possible. However, caution is required when interpreting our findings. Further studies, especially well-designed randomized controlled clinical trials are awaited to confirm the association between SLE and cervical atypia-associated diseases.PMID:34715754 | DOI:10.1177/09612033211048129
Source: Lupus - October 30, 2021 Category: Rheumatology Authors: Yanya Chen Xuewei Wu Lu Liu Source Type: research

The Association Between Sex and Survival for Anal Squamous Cell Carcinoma
CONCLUSIONS: We demonstrate better overall survival for females compared to males for stage I-IV anal SCC. It is not clear why women have a survival advantage over men, though exposure to prominent risk factors may play a role. High-risk men may warrant routine screening for anal cancer.PMID:34425409 | DOI:10.1016/j.jss.2021.07.015
Source: Cell Research - August 23, 2021 Category: Cytology Authors: Vanessa M Welten Adam C Fields Robert A Malizia James Yoo Jennifer L Irani Ronald Bleday Joel E Goldberg Nelya Melnitchouk Source Type: research

Physiopathology and effectiveness of therapeutic vaccines against human papillomavirus
Environ Sci Pollut Res Int. 2021 Jul 21. doi: 10.1007/s11356-021-15441-w. Online ahead of print.ABSTRACTHuman papillomavirus (HPV) is a well-known sexually transmitted disorder globally. Human papillomavirus (HPV) is the 3rd most common cancer that causes cervical carcinoma, and globally it accounts for 275,000 deaths every year. The load of HPV-associated abrasions can be lessened through vaccination. At present, three forms of prophylactic vaccines, Cervarix, Gadrasil, and Gardasil 9, are commercially accessible but all these prophylactic vaccines have not the ability to manage and control developed abrasions or infectio...
Source: Cell Research - July 22, 2021 Category: Cytology Authors: Noor Ayesha Sara Aboulaghras Muhammad Jahangeer Areej Riasat Rehana Ramzan Rameen Fatima Muhammad Akram Abdelaali Balahbib Abdelhakim Bouyahya Ekaterina Sepiashvili Gokhan Zengin Mohammad Ali Shariati Source Type: research

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