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Total 53 results found since Jan 2013.
Effectiveness and safety of atezolizumab-bevacizumab in patients with unresectable hepatocellular carcinoma: a systematic review and meta-analysis
EClinicalMedicine. 2023 Aug 30;63:102179. doi: 10.1016/j.eclinm.2023.102179. eCollection 2023 Sep.ABSTRACTBACKGROUND: Atezolizumab-bevacizumab (atezo-bev) is recommended as first-line therapy for patients with unresectable hepatocellular carcinoma (uHCC). However, its effectiveness and safety in other populations, including those with Child-Turcotte-Pugh (CTP) class B cirrhosis, is unclear.METHODS: For this systematic review and meta-analysis, electronic databases, including PubMed, Embase, and Scopus, were searched from 1st May, 2020 till 5th October, 2022; the last date of access was January 31, 2023. Pooled progression-...
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Anand V Kulkarni Harshvardhan Tevethia Karan Kumar Madhumita Premkumar Mark D Muttaiah Atsushi Hiraoka Takeshi Hatanaka Toshifumi Tada Takashi Kumada Satoru Kakizaki Arndt Vogel Richard S Finn Padaki Nagaraja Rao Anjana Pillai Duvvur Nageshwar Reddy Amit Source Type: research
RUNX-3-expressing CAR T cells targeting glypican-3 in patients with heavily pretreated advanced hepatocellular carcinoma: a phase I trial
This study was funded by CARsgen Therapeutics Co., Ltd.PMID:37680942 | PMC:PMC10480529 | DOI:10.1016/j.eclinm.2023.102175
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Qihan Fu Yi Zheng Weijia Fang Qingwei Zhao Peng Zhao Lulu Liu You Zhai Zhou Tong Hangyu Zhang Meihua Lin Xudong Zhu Huamao Wang Yumeng Wang Zhen Liu Daijing Yuan Xuanwen Bao Wanwan Gao Xiaomeng Dai Zonghai Li Tingbo Liang Source Type: research
Personalised decision making to predict absolute metastatic risk in cutaneous squamous cell carcinoma: development and validation of a clinico-pathological model
EClinicalMedicine. 2023 Aug 19;63:102150. doi: 10.1016/j.eclinm.2023.102150. eCollection 2023 Sep.ABSTRACTBACKGROUND: Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer, affecting more than 2 million people worldwide yearly and metastasising in 2-5% of patients. However, current clinical staging systems do not provide estimates of absolute metastatic risk, hence missing the opportunity for more personalised treatment advice. We aimed to develop a clinico-pathological model that predicts the probability of metastasis in patients with cSCC.METHODS: Nationwide cohorts from (1) all patients with a first primary c...
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Barbara Rentroia-Pacheco Selin Tokez Edo M Bramer Zoe C Venables Harmen J G van de Werken Domenico Bellomo David van Klaveren Antien L Mooyaart Loes M Hollestein Marlies Wakkee Source Type: research
Camrelizumab plus famitinib in patients with recurrent or metastatic nasopharyngeal carcinoma treated with PD-1 blockade: data from a multicohort phase 2 study
EClinicalMedicine. 2023 Jun 23;61:102043. doi: 10.1016/j.eclinm.2023.102043. eCollection 2023 Jul.ABSTRACTBACKGROUND: Treatment options for patients with recurrent/metastatic nasopharyngeal carcinoma (RM-NPC) are not clear after progression on previous treatment with PD-(L)1 inhibitor; critical gaps in evidence remain for such cases. Immunotherapy combined with antiangiogenic therapy has been reported to have synergistic antitumor activity. Therefore, we evaluated the efficacy and safety of camrelizumab plus famitinib in patients with RM-NPC who failed treatment with PD-1 inhibitor-containing regimens.METHODS: This multice...
Source: Cancer Control - July 7, 2023 Category: Cancer & Oncology Authors: Xi Ding Yi-Jun Hua Xiong Zou Xiao-Zhong Chen Xi-Mei Zhang Bei Xu Yan-Feng Ouyang Zi-Wei Tu Hui-Feng Li Chong-Yang Duan Wei-Jing Zhang Rui You You-Ping Liu Yong-Long Liu Qi Yang Pei-Yu Huang Shu-Ni Wang Jia Fan Ming-Yuan Chen Source Type: research
A comprehensive evaluation of full-spectrum cell-free RNAs highlights cell-free RNA fragments for early-stage hepatocellular carcinoma detection
This study comprehensively evaluated full-spectrum cfRNA biomarker types for HCC detection, highlighted the cfRNA fragment as a promising biomarker type in HCC detection, and provided a panel HCCMDP.FUNDING: National Natural Science Foundation of China, and The National Key Basic Research Program (973 program).PMID:37315449 | DOI:10.1016/j.ebiom.2023.104645
Source: Cancer Control - June 14, 2023 Category: Cancer & Oncology Authors: Chun Ning Peng Cai Xiaofan Liu Guangtao Li Pengfei Bao Lu Yan Meng Ning Kaichen Tang Yi Luo Hua Guo Yunjiu Wang Zhuoran Wang Lu Chen Zhi John Lu Jianhua Yin Source Type: research
Dose-escalated simultaneous integrated boost radiotherapy in early breast cancer (IMPORT HIGH): a multicentre, phase 3, non-inferiority, open-label, randomised controlled trial
Lancet. 2023 Jun 8:S0140-6736(23)00619-0. doi: 10.1016/S0140-6736(23)00619-0. Online ahead of print.ABSTRACTBACKGROUND: A tumour-bed boost delivered after whole-breast radiotherapy increases local cancer-control rates but requires more patient visits and can increase breast hardness. IMPORT HIGH tested simultaneous integrated boost against sequential boost with the aim of reducing treatment duration while maintaining excellent local control and similar or reduced toxicity.METHODS: IMPORT HIGH is a phase 3, non-inferiority, open-label, randomised controlled trial that recruited women after breast-conserving surgery for pT1-...
Source: Cancer Control - June 11, 2023 Category: Cancer & Oncology Authors: Charlotte E Coles Joanne S Haviland Anna M Kirby Clare L Griffin Mark A Sydenham Jenny C Titley Indrani Bhattacharya A Murray Brunt H Y Charlie Chan Ellen M Donovan David J Eaton Marie Emson Penny Hopwood Monica L Jefford Sara V Lightowlers Elinor J Sawye Source Type: research
Cochrane Lifetime and Emeritus Members
Cochrane is proud to announce new lifetime and emeritus memberships,recognizing the extraordinary contributions of individuals who have made an exceptional, long-standing contribution to Cochrane ’s work and leadership.Cochrane ' s strength is in its collaborative, global community. Over the last 30 years, our members and supporters from more than 130 countries have worked together to produce credible, accessible health information and help inform health decision-making. Though we are spread out across the globe, our shared passion for health evidence unites us.Cochrane ’s Membership schemehelps reward everyone who hel...
Source: Cochrane News and Events - May 3, 2023 Category: Information Technology Authors: Muriah Umoquit Source Type: news
Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo.
T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions
https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/
Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in this...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Applying PET-CT for predicting the efficacy of SBRT to inoperable early-stage lung adenocarcinoma: A Brazilian case-series
Lancet Reg Health Am. 2022 Mar 30;11:100241. doi: 10.1016/j.lana.2022.100241. eCollection 2022 Jul.ABSTRACTBACKGROUND: Stereotactic body radiotherapy (SBRT) is a treatment option for early-stage inoperable primary lung cancer. Here we report a thorough description of the prognostic value of pre-SBRT SUVmax for predicting the efficacy of SBRT in early-stage lung adenocarcinoma.METHODS: This is a retrospective study of consecutive cases of early-stage inoperable lung adenocarcinoma, staged with PET-CT, treated with SBRT between 2007 and 17. Kaplan-Meier (KM) curves were used to assess overall survival and compare time to eve...
Source: Cancer Control - February 13, 2023 Category: Cancer & Oncology Authors: Fabio Y Moraes Carlos E C V Abreu Gabriela S M Siqueira Cecilia K Haddad Fabiana A M Degrande Wilma M Hopman Wellington F P Neves-Junior Rafael Gadia Heloisa A Carvalho Source Type: research
Discovery and Evaluation of Extracellular MicroRNA Biomarkers in Plasma, Ascites, and Urine
Methods Mol Biol. 2023;2630:135-143. doi: 10.1007/978-1-0716-2982-6_10.ABSTRACTMicroRNAs (miRNAs) comprise a large group of small noncoding RNAs within a heterogeneous entity of noncoding RNAs, forming potent functional tools regulating the crucial biological processes within cells and the body. Cell-free miRNAs have become one of the novel promising diagnostic, predictive, and prognostic biomarkers for various diseases extensively investigated in recent years. This is due to their presence within extracellular fractions of various body fluids suggesting their potential as noninvasive "liquid biopsy" in case of their dysre...
Source: Mol Biol Cell - January 23, 2023 Category: Molecular Biology Authors: Lud ěk Záveský Ond řej Slanař Source Type: research
Construction and validation of a novel ten miRNA-pair based signature for the prognosis of clear cell renal cell carcinoma
This study was supported by research grants from the China National Natural Scientific Foundation (81903972, 82002018, and 82170752) and Shanghai Sailing Program (19YF1406700 and 20YF1406000).PMID:35998436 | DOI:10.1016/j.tranon.2022.101519
Source: Translational Oncology - August 23, 2022 Category: Cancer & Oncology Authors: Yulin Wang Ziyan Shen Shaocong Mo Leijie Dai Biao Song Wenchao Gu Xiaoqiang Ding Xiaoyan Zhang Source Type: research
Effect of glycated haemoglobin A1c on the survival of patients with oral squamous cell carcinoma and diabetes: a multicentre, retrospective, database cohort study
Lancet Oncol. 2022 Jul;23 Suppl 1:S23. doi: 10.1016/S1470-2045(22)00422-3.ABSTRACTBACKGROUND: Few studies have evaluated the effect of glucose concentrations on cancer prognosis. We investigated the association between haemoglobin A1c (HbA1c) concentrations and survival in patients with oral squamous cell carcinoma.METHODS: A 19-year retrospective cohort study of patients with oral squamous cell carcinoma was done using the Chang Gung Research Database to identify 7279 patients diagnosed with oral cancer between Jan 1, 2001, and June 30, 2020. A 1:2 frequency-matching ratio between patients with diabetes and patients witho...
Source: Cancer Control - July 15, 2022 Category: Cancer & Oncology Authors: Chun-Yuan Chao Sheng-Dean Luo Wei-Chih Chen Shao-Chun Wu Tai-Jan Chiu Yu-Ming Wang Yao-Hsu Yang Fu-Min Fang Chung-Yi Li Ching-Nung Wu Source Type: research
Early detection of hepatocellular carcinoma with methylation and fragmentation signatures of circulating tumour DNA: a prospective, multicentre, case-control, observational study
This study was supported by the National Key Research and Development Program of China (grant number 2019YFC1315800).PMID:35837910 | DOI:10.1016/S1470-2045(22)00414-4
Source: Cancer Control - July 15, 2022 Category: Cancer & Oncology Authors: Xinrong Yang Jian Zhou Jia Fan De-Zhen Guo Ao Huang Chengcheng Ma Minjie Xu Wei Li Zhixi Su Source Type: research
