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Cell-penetrating albumin enhances the sublingual delivery of antigens through macropinocytosis
Int J Biol Macromol. 2022 Sep 17:S0141-8130(22)02063-3. doi: 10.1016/j.ijbiomac.2022.09.132. Online ahead of print.ABSTRACTInnovations in oral immunotherapy have greatly advanced the therapeutic control of allergies. However, these therapeutic effects suffer from the fact that the amount of antigen delivered to antigen-presenting cells is limited given the formulations that are currently available. We recently designed a cell-penetrating albumin and found that this modified albumin enters cells via the induction of macropinocytosis. Herein, we report on a novel system for delivering antigens based on cell-penetrating album...
Source: International Journal of Biological Macromolecules - September 20, 2022 Category: Biochemistry Authors: Hitoshi Maeda Shota Ichimizu Hiroshi Watanabe Keisuke Hamasaki Mayuko Chikamatsu Ryota Murata Nao Yumoto Takahiro Seki Hiroshi Katsuki Masaki Otagiri Toru Maruyama Source Type: research

Characterization of outcomes in patients with advanced genitourinary malignancies treated with immune checkpoint inhibitors.
CONCLUSION: Greater frequency and higher grades of irAEs are associated with better treatment response in patients with RCC and urothelial malignancy receiving ICI therapy. The presence of liver metastases denotes a negative predictive marker for immunotherapy efficacy. SUMMARY: Immune checkpoint inhibitors (ICI) are increasingly used to treat genitourinary (GU) malignancies. However, clinical data regarding patients with advanced-stage GU malignancies treated with ICI is lacking. Thus, we performed a single-center, retrospective cohort study on patients with metastatic and unresectable renal cell carcinoma (RCC) and ...
Source: Urologic Oncology - January 22, 2021 Category: Urology & Nephrology Authors: Ma VT, Su CT, Hu M, Taylor JMG, Daignault-Newton S, Kellezi O, Dahl MN, Shah MA, Erickson S, Lora J, Hamasha R, Ali A, Yancey S, Kiros L, Balicki HM, Winfield DC, Green MD, Alva AS Tags: Urol Oncol Source Type: research

Human Gut-Associated Natural Killer Cells in Health and Disease
Alessandro Poggi1*, Roberto Benelli2, Roberta Venè1, Delfina Costa1, Nicoletta Ferrari1, Francesca Tosetti1 and Maria Raffaella Zocchi3 1Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 3Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research