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Nicotinic acetylcholine receptors in cancer: Limitations and prospects
Biochim Biophys Acta Mol Basis Dis. 2023 Sep 4:166875. doi: 10.1016/j.bbadis.2023.166875. Online ahead of print.ABSTRACTNicotinic acetylcholine receptors (nAChRs) have long been considered to solely mediate neurotransmission. However, their widespread distribution in the human body suggests a more diverse physiological role. Additionally, the expression of nAChRs is increased in certain cancers, such as lung cancer, and has been associated with cell proliferation, epithelial-to-mesenchymal cell transition, angiogenesis and apoptosis prevention. Several compounds that interact with these receptors have been identified as po...
Source: Biochimica et Biophysica Acta - September 6, 2023 Category: Biochemistry Authors: T Bele T Turk I Kri žaj Source Type: research

Comparative analyses of transcriptome sequencing and carcinogenic exposure toxicity of nicotine and 6-methyl nicotine in human bronchial epithelial cells
Toxicol In Vitro. 2023 Aug 14:105661. doi: 10.1016/j.tiv.2023.105661. Online ahead of print.ABSTRACTElectronic cigarettes have become a purported safer alternative to the conventional cigarettes in recent years. Nicotine is the main component of electronic cigarettes, and other nicotinic compounds are synthesized as alternatives to nicotine. However, scientific data on the potential health effects of electronic cigarettes are scarce. Herein, we evaluated the cytotoxicity of nicotine and its analog 6-methyl nicotine (6-MN) on human bronchial epithelial cells (BEAS-2B cells) in vitro. Furthermore, we performed transcriptome ...
Source: Toxicology in Vitro - August 16, 2023 Category: Toxicology Authors: Huaiyuan Qi Xia Chang Ke Wang Qiaoxin Xu Meisen Liu Bin Han Source Type: research

Transcription factor Sp1 and oncoprotein PPP1R13L regulate nicotine-induced epithelial-mesenchymal transition in lung adenocarcinoma via a feedback loop
Biochem Pharmacol. 2022 Nov 10:115344. doi: 10.1016/j.bcp.2022.115344. Online ahead of print.ABSTRACTTobacco remains the most common environmental carcinogen leading to the occurrence and development of lung cancer. Nicotine, a tumor promoter in cigarette smoke, has been shown to induce epithelial-mesenchymal transition (EMT), a cellular program required for the invasion and metastasis in tumor cells. Specificity Protein 1 (Sp1) is a well-characterized transcription factor that can regulate the EMT process via transcriptionally activating E-cadherin expression. Protein Phosphatase 1 Regulatory Subunit 13 Like (PPP1R13L) is...
Source: Biochemical Pharmacology - November 13, 2022 Category: Drugs & Pharmacology Authors: Hongchao Zhang Guopei Zhang Jingyue Zhang Mingyang Xiao Su Cui Shengwen Wu Cuihong Jin Jinghua Yang Xiaobo Lu Source Type: research

Molecular mechanisms underlying the action of carcinogens in gastric cancer with a glimpse into targeted therapy
CONCLUSIONS: In this review, we highlight recent clinical trial data reported in the literature dealing with different ways to target various carcinogens in gastric cancer. Moreover, we touch upon other multidisciplinary therapeutic approaches such as surgery, adjuvant and neoadjuvant chemotherapy. Rational clinical trials focusing on identifying suitable patient populations are imperative to the success of single-agent therapeutics. Novel insights regarding signaling pathways that regulate gastric cancer can potentially improve treatment responses to targeted therapy alone or in combination with other/conventional treatme...
Source: Cancer Control - September 23, 2022 Category: Cancer & Oncology Authors: Elham Patrad Solmaz Khalighfard Taghi Amiriani Vahid Khori Ali Mohammad Alizadeh Source Type: research

Impact of E-Cigarette Aerosol on Primary Human Alveolar Epithelial Type 2 Cells
Am J Physiol Lung Cell Mol Physiol. 2022 Jun 7. doi: 10.1152/ajplung.00503.2021. Online ahead of print.ABSTRACTElectronic cigarettes (e-cigarettes) are designed to simulate combustible cigarette smoking and to aid in smoking cessation. Although the number of e-cigarette users has been increasing, the health impacts and biological effects of e-cigarettes are still not fully understood. Previous research has focused on the biological effects of e-cigarettes on lung cancer cell lines and distal airway epithelial cells; however, there have been few published studies on the effect of e-cigarettes on primary lung alveolar epithe...
Source: Am J Physiol Lung Ce... - June 7, 2022 Category: Respiratory Medicine Authors: Katherine D Wick Xiaohui Fang Mazharul Maishan Shotaro Matsumoto Natasha Spottiswoode Aartik Sarma Camille Simoneau Manisha Khakoo Chaz Langelier Carolyn S Calfee Jeffrey Earl Gotts Michael A Matthay Source Type: research

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