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Total 145 results found since Jan 2013.
Corrigendum Cryptotanshinone inhibits IgE ‑mediated degranulation through inhibition of spleen tyrosine kinase and tyrosine‑protein kinase phosphorylation in mast cells
In this study, novel function of CRT on phosphorylations of Lyn/Syk kinases in mast cells is elucidated for the first time. Furthermore, it is likely that this inhibitory effect of CRT on Lyn/Syk kinases negatively affected activities of their downstream signalling molecules including PLCγ, PKCδ, and IKKβ, which leads to decrease in mast cell degranulation by CRT treatment. Besides the inhibitory effect of CRT on mast cell degranulation, here we provide additional evidence that CRT exerts anti-AD effects through inactivation of MAPK and NF‑κB. It has been reported that CRT regulates the activities of MAPK and NF‑κ...
Source: Molecular Medicine Reports - July 19, 2021 Category: Molecular Biology Authors: Sumiyasuren Buyanravjikh Sora Han Sunyi Lee Ae Lee Jeong Hye In Ka Ji Young Park Ariundavaa Boldbaatar Jong-Seok Lim Myeong-Sok Lee Young Yang Source Type: research
Altered Expression Levels of MicroRNA-155 and SOCS-1 in Peripheral Blood Mononuclear Cells of Newly Diagnosed Breast Cancer Patients
This study investigated the association of inflammatory changes with the variations of miR-155 expression in newly diagnosed breast cancer (NDBC) patients. Seventy NDBC patients were categorized as lobular and ductal subgroups and forty healthy individuals participated in this study. The expression rate of miR-155 and its downstream target gene, SOCS-1, as well as the plasma levels of IL-6, were evaluated in peripheral blood mononuclear cells of NDBC patients; using real-time PCR and enzyme-linked immunosorbent assay, respectively. Our results indicated an over-expression of miR-155 in the PBMCs of NDBC patients which was ...
Source: Cancer Control - May 7, 2022 Category: Cancer & Oncology Authors: Sara Iranparast Maryam Tahmasebi-Birgani Azim Motamedfar Afshin Amari Mehri Ghafourian Source Type: research
Potential of Anti-inflammatory Molecules in the Chemoprevention of Breast Cancer
This article gives a comprehensive overview of the recent advancements in using anti-inflammatory molecules in chemoprevention of breast cancer along with their mechanism of action, supported by latest preclinical and clinical data. The merits of anti-inflammatory chemopreventive agents in prevention of cardiotoxicity have been described. We have also highlighted the ongoing research and advancements in improving the efficacy of using anti-inflammatory molecules as chemopreventive agents.PMID:36043708 | DOI:10.2174/2772270816666220829090716
Source: Adv Data - August 31, 2022 Category: Epidemiology Authors: Vaishnavi Gadi Saritha Shetty Source Type: research
The Increasing Role of SOX10 in Diagnostic Breast Pathology The Increasing Role of SOX10 in Diagnostic Breast Pathology
A recent study confirms the usefulness of the transcription factor SOX10 in the practice of breast pathology, primarily as a marker for triple-negative breast carcinoma.American Journal of Clinical Pathology
Source: Medscape Allergy Headlines - November 24, 2022 Category: Allergy & Immunology Tags: Pathology & Lab Medicine Journal Article Source Type: news
< em > Dolomiaea costus: < /em > an untapped mine of sesquiterpene lactones with wide magnificent biological activities
Nat Prod Res. 2023 Jan 10:1-11. doi: 10.1080/14786419.2022.2164577. Online ahead of print.ABSTRACTDolomiaea costus (Falc.) Kasana & A.K. Pandey Family Asteraceae, formerly known as Saussurea costus (Falc.) Lipsch contains a rich treasury of diverse bioactive compounds such as monoterpenes, sesquiterpenes, triterpenes, sterols, cardenolides, flavonoids, coumarins, lignans, phenylpropanoids and alkaloids. The sesquiterpene lactones, costunolide and dehydrocostuslactone in D. costus, possess unique promising in vitro and in vivo biological activities for the prevention and cure of diverse ailments like Parkinson's disease...
Source: Natural Product Research - January 10, 2023 Category: Biochemistry Authors: Ebraheem Abouelwafa Amal Zaki Omar M Sabry Giovanni Caprioli Essam Abdel-Sattar Source Type: research
