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Total 121 results found since Jan 2013.
Control groups for HIV prevention efficacy trials: what does the future hold?
Curr Opin HIV AIDS. 2023 Sep 12. doi: 10.1097/COH.0000000000000818. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Ending the HIV epidemic will require the development of additional effective immune-mediated and nonimmune-mediated means of HIV prevention. Evaluating novel interventions requires large, controlled trials demonstrating efficacy. Recent advances in the field of HIV prevention necessitate new approaches to efficacy trial design.RECENT FINDINGS: Three classes of efficacy trial designs are possible: standard of prevention-controlled trials, active-controlled trials, and active-controlled trials augmented with e...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Holly Janes Susan Buchbinder Source Type: research
Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models.
The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Production of monoclonal antibodies for therapeutic purposes: A review
Int Immunopharmacol. 2023 May 25;120:110376. doi: 10.1016/j.intimp.2023.110376. Online ahead of print.ABSTRACTMonoclonal antibodies (mAbs) have been used in the development of immunotherapies that target a variety of diseases, such as cancer, autoimmune diseases, and even viral infections; they play a key role in immunization and are expected after vaccination. However, some conditions do not promote the development of neutralizing antibodies. Production and use of mAbs, generated in biofactories, represent vast potential as aids in immunological responses when the organism cannot produce them on their own, these convey un...
Source: International Immunopharmacology - May 27, 2023 Category: Allergy & Immunology Authors: Waller-Pulido Alejandra Jim énez-Pérez Miriam Irene Gonzalez-Sanchez Fabio Antonio Rojo-Gutierrez Rocio Patricia Torres-Anguiano Elizabeth Aleman-Aguilar Juan Pablo Garcia-Varela Rebeca Source Type: research
Role of Low-Risk HPV PCR Monoinfection in Screening for HSIL and Anal Cancer in Men Who Have Sex with Men Living with HIV
Int J Mol Sci. 2023 Mar 15;24(6):5642. doi: 10.3390/ijms24065642.ABSTRACTTo determine the value of low-risk human papillomavirus (HPV) PCR to screen for "high-grade anal squamous intraepithelial lesion and anal cancer" (HSIL-plus), rate of patients with low-grade anal squamous intraepithelial lesion (LSIL) progressing to HSIL-plus, and progression-related factors. Prospective, longitudinal study of consecutive MSM-LHIV attended between May 2010 and December 2021 and followed for 43 months (IQR: 12-76). HIV-related variables were gathered at baseline, performing anal cytology for HPV detection/genotyping, thin-layer cytolog...
Source: Anal Sci - March 29, 2023 Category: Chemistry Authors: Carmen Mar ía García-Martínez Inmaculada Calle-G ómez Javier L ópez-Hidalgo Patricia G ómez-Ronquillo Mohamed Omar-Mohamed Balgahata Carmen Hidalgo-Tenorio Source Type: research
Hepatitis A seroprevalence among special populations in the Rio de Janeiro Metropolitan Area, Brazil
The objectives were to estimate hepatitis A virus seroprevalence in subjects attending to a travel medicine and immunization clinic in Rio de Janeiro, Brazil, and to develop a prediction model for hepatitis A virus seroprevalence. This retrospective research included individuals sequentially from April 2011 to June 2019 at a travel medicine and special population immunization clinic with an anti-hepatitis A virus IgG chemiluminescence result. Participants' data were verified via electronic medical records. Data were split into development and validation set taking 2018 as the date break. A cross-validated elastic generaliz...
Source: Cadernos de Saude Publica - March 22, 2023 Category: International Medicine & Public Health Authors: Flavio de Carvalho Luciana Gomes Pedro Brand ão Margaret Catoia Varela Mari Tuyama Danusa Ferreira Correa Ananza Taina da Silva Santos Alberto Dos Santos de Lemos Marcellus Dias da Costa Jos é Cerbino-Neto Pedro Emmanuel Alvarenga Americano do Brasil Source Type: research
Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo.
T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions
https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/
Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in this...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Direct intranodal tonsil vaccination with modified vaccinia Ankara vaccine protects macaques from highly pathogenic SIVmac251
Nat Commun. 2023 Mar 7;14(1):1264. doi: 10.1038/s41467-023-36907-0.ABSTRACTHuman immunodeficiency virus (HIV) is a mucosally transmitted virus that causes immunodeficiency and AIDS. Developing efficacious vaccines to prevent infection is essential to control the epidemic. Protecting the vaginal and rectal mucosa, the primary routes of HIV entry has been a challenge given the significant compartmentalization between the mucosal and peripheral immune systems. We hypothesized that direct intranodal vaccination of mucosa associated lymphoid tissue (MALT) such as the readily accessible palatine tonsils could overcome this compa...
Source: Cancer Control - March 7, 2023 Category: Cancer & Oncology Authors: Jeffy G Mattathil Asisa Volz Olusegun O Onabajo Sean Maynard Sandra L Bixler Xiaoying X Shen Diego Vargas-Inchaustegui Marjorie Robert-Guroff Celia Lebranche Georgia Tomaras David Montefiori Gerd Sutter Joseph J Mattapallil Source Type: research
