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Total 412620 results found since Jan 2013.
Targeting the NAD+ Salvage Pathway: Synergistic Therapeutic Strategy for ER+ Metastatic Breast Cancer
Endocrinology. 2023 Sep 20:bqad140. doi: 10.1210/endocr/bqad140. Online ahead of print.NO ABSTRACTPMID:37738166 | DOI:10.1210/endocr/bqad140
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Rebecca B Riggins Suman Ranjit Source Type: research
Loss of Chromosome 3q Is a Prognostic Marker in Fusion-Negative Rhabdomyosarcoma
CONCLUSION: The pathogenesis of STS including FN-RMS remains poorly understood, emphasizing the need for new therapeutic advances and adequate risk stratification. Our data demonstrate that loss of chr3q is associated with poor OS in FN-RMS, supporting it as an important tool for risk stratification.PMID:37738543 | DOI:10.1200/PO.23.00037
Source: Ann Oncol - September 22, 2023 Category: Cancer & Oncology Authors: Carina A Dehner Robert C Bell Yang Cao Kevin He John S A Chrisinger Amy E Armstrong Marielle Yohe Jack Shern Angela C Hirbe Source Type: research
ctDNA-guided adjuvant treatment after radical-intent treatment of metastatic spread from colorectal cancer-the first interim results from the OPTIMISE study
CONCLUSION: The study was proven to be feasible and continues in the planned large-scale phase II trial. Results from the OPTIMISE study will potentially optimize the adjuvant treatment of patients undergoing radical-intent treatment of mCRC, thereby improving survival and reducing chemotherapy-related toxicity.PMID:37738268 | DOI:10.1080/0284186X.2023.2259083
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: Louise Bach Callesen Torben Fr østrup Hansen Rikke Fredslund Andersen Niels Pallisgaard Stine Kramer Sven Schlander S øren Rafael Rafaelsen Anders Kindberg Boysen Lars Henrik Jensen Anders Jakobsen Karen-Lise Garm Spindler Source Type: research
Accuracy of Essential TNM to stage large colorectal (T3/T4) cancers in absence of nodal status information
Acta Oncol. 2023 Sep 22:1-3. doi: 10.1080/0284186X.2023.2257376. Online ahead of print.NO ABSTRACTPMID:37738263 | DOI:10.1080/0284186X.2023.2257376
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: Marion Pi ñeros James Brierley Enrique Barrios Patricia Cueva Carina Musetti Constanza Pardo Kevin Ward D Maxwell Parkin Source Type: research
The diagnostic likelihood ratio function and modified test for trend: Identifying, evaluating, and validating nontraditional biomarkers in case-control studies
Stat Med. 2023 Sep 21. doi: 10.1002/sim.9912. Online ahead of print.ABSTRACTThe ROC curve and its associated summary statistic, the AUC, are used to identify informative diagnostic biomarkers under the assumption that risk of disease is a monotone function of the biomarker. We refer to biomarkers that meet this assumption as traditional, and those that do not as nontraditional. Nontraditional biomarkers most often arise when both low and high biomarker values are associated with an outcome of interest, such as blood pressure with medical complications or leukocyte count with ICU prognosis. Since nontraditional biomarkers d...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Hanna Lindner Phyllis A Gimotty Warren B Bilker Source Type: research
CT-Guided Percutaneous Cryoablation for Lung Metastasis of Colorectal Cancer: A Case Series
CONCLUSION: Lung CA is a safe and well-tolerated treatment with a satisfactory local control rate for patients with lung metastases derived from mCRC.PMID:37735896 | DOI:10.1177/15330338231201508
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Fu-Ming Wang Rong Luo Jin-Ming Tian Hang Liu Ji-Jin Yang Source Type: research
Establishing molecular pathology curriculum for pathology trainees and continued medical education: a collaborative work from the Molecular Pathology Study Group of the Korean Society of Pathologists
CONCLUSIONS: Approach toward the education of molecular pathology was refined, which would greatly benefit the future trainees.PMID:37735877 | DOI:10.4132/jptm.2023.08.26
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Jiwon Koh Ha Young Park Jeong Mo Bae Jun Kang Uiju Cho Seung Eun Lee Haeyoun Kang Min Eui Hong Jae Kyung Won Youn-La Choi Wan-Seop Kim Ahwon Lee Source Type: research
METTL5-mediated 18S rRNA m < sup > 6 < /sup > A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression
Mol Ther. 2023 Sep 20:S1525-0016(23)00501-4. doi: 10.1016/j.ymthe.2023.09.014. Online ahead of print.ABSTRACTIntrahepatic cholangiocarcinoma (ICC) is a deadly cancer with rapid tumor progression. While hyperactive mRNA translation caused by mis-regulated mRNA or tRNA modifications promotes ICC development, the role of rRNA modifications remains elusive. Here, we found that 18S rRNA m6A modification and its methyltransferase METTL5 were aberrantly upregulated in ICC and associated with poorer survival (Log rank test, p<0.05). We further revealed the critical role of METTL5-mediated 18S rRNA m6A modification in regulation...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Zihao Dai Wanjie Zhu Yingdong Hou Xinyue Zhang Xuxin Ren Kai Lei Junbin Liao Haining Liu Zhihang Chen Sui Peng Shaoqiang Li Shuibin Lin Ming Kuang Source Type: research
Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
CONCLUSIONS: Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.PMID:37735756 | DOI:10.1158/1078-0432.CCR-22-3987
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ciara L Freeman Reginald Atkins Indumathy Varadarajan Meghan Menges Jeffrey Edelman Rachid Baz Jason Brayer Omar Castaneda Puglianini Jose Leonel Ochoa-Bayona Taiga Nishihori Kenneth H Shain Bijal Shah Dung Tsa Chen Linda Kelley Domenico Coppola Melissa A Source Type: research
The long non-coding RNA BBOX1 antisense RNA 1 is upregulated in polycystic ovary syndrome (PCOS) and suppresses the role of microRNA-19b in the proliferation of ovarian granulose cells : Short title: BBOX1 antisense RNA 1 in cell proliferation
CONCLUSION: BBOX1-AS1 is highly upregulated in PCOS, and it may serve as an endogenous competing RNA for miR-19b to suppress its role in inhibiting granulosa cell proliferation. Our study suggested the role of BBOX1-AS1 as a potential target to treat PCOS.PMID:37735639 | DOI:10.1186/s12905-023-02632-5
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Zhi Zhou Yong Zhang Can Tan Juan Zhang Guohui Yi Bangbei Wang Yejuan Li Hui Lu Weiying Lu Xiaopo Zhang Source Type: research
Preoperative treatment with mFOLFIRINOX or Gemcitabine/Nab-paclitaxel +/- isotoxic high-dose stereotactic body Radiation Therapy (iHD-SBRT) for borderline resectable pancreatic adenocarcinoma (the STEREOPAC trial): study protocol for a randomised comparative multicenter phase II trial
DISCUSSION: This trial will help define the best neoadjuvant treatment sequence for borderline resectable PDAC and aims to evaluate if a total neoadjuvant treatment integrating iHD-SBRT improves the patients' oncological outcomes.TRIAL REGISTRATION: The study was registered at ClinicalTrails.gov (NCT05083247) on October 19th, 2021, and in the Clinical Trials Information System (CTIS) EU CT database (2022-501181-22-01) on July 2022.PMID:37735634 | DOI:10.1186/s12885-023-11327-x
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Christelle Bouchart Julie Navez Ivan Borbath Karen Geboes Timon Vandamme Jean Closset Luigi Moretti Pieter Demetter Marianne Paesmans Jean-Luc Van Laethem Source Type: research
Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes
Nat Immunol. 2023 Sep 21. doi: 10.1038/s41590-023-01631-w. Online ahead of print.ABSTRACTNoncoding genetic variation drives phenotypic diversity, but underlying mechanisms and affected cell types are incompletely understood. Here, investigation of effects of natural genetic variation on the epigenomes and transcriptomes of Kupffer cells derived from inbred mouse strains identified strain-specific environmental factors influencing Kupffer cell phenotypes, including leptin signaling in Kupffer cells from a steatohepatitis-resistant strain. Cell-autonomous and non-cell-autonomous effects of genetic variation were resolved by ...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Hunter Bennett Ty D Troutman Enchen Zhou Nathanael J Spann Verena M Link Jason S Seidman Christian K Nickl Yohei Abe Mashito Sakai Martina P Pasillas Justin M Marlman Carlos Guzman Mojgan Hosseini Bernd Schnabl Christopher K Glass Source Type: research
ORM1 promotes tumor progression of kidney renal clear cell carcinoma (KIRC) through CALR-mediated apoptosis
This study provides us a new way to recognize the development and progression in KIRC.PMID:37735575 | DOI:10.1038/s41598-023-42962-w
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Gang Yu Juan Gao Weifeng Hu Dayong Hu Weibing Wang Shiquan Yang Jing Gao Source Type: research
Spatiotemporal, optogenetic control of gene expression in organoids
Nat Methods. 2023 Sep 21. doi: 10.1038/s41592-023-01986-w. Online ahead of print.ABSTRACTOrganoids derived from stem cells have become an increasingly important tool for studying human development and modeling disease. However, methods are still needed to control and study spatiotemporal patterns of gene expression in organoids. Here we combined optogenetics and gene perturbation technologies to activate or knock-down RNA of target genes in programmable spatiotemporal patterns. To illustrate the usefulness of our approach, we locally activated Sonic Hedgehog (SHH) signaling in an organoid model for human neurodevelopment. ...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ivano Legnini Lisa Emmenegger Alessandra Zappulo Agnieszka Rybak-Wolf Ricardo Wurmus Anna Oliveras Martinez Cledi Cerda Jara Anastasiya Boltengagen Tal é Hessler Guido Mastrobuoni Stefan Kempa Robert Zinzen Andrew Woehler Nikolaus Rajewsky Source Type: research
A H3K27M-targeted vaccine in adults with diffuse midline glioma
Nat Med. 2023 Sep 21. doi: 10.1038/s41591-023-02555-6. Online ahead of print.ABSTRACTSubstitution of lysine 27 to methionine in histone H3 (H3K27M) defines an aggressive subtype of diffuse glioma. Previous studies have shown that a H3K27M-specific long peptide vaccine (H3K27M-vac) induces mutation-specific immune responses that control H3K27M+ tumors in major histocompatibility complex-humanized mice. Here we describe a first-in-human treatment with H3K27M-vac of eight adult patients with progressive H3K27M+ diffuse midline glioma on a compassionate use basis. Five patients received H3K27M-vac combined with anti-PD-1 treat...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Niklas Grassl Isabel Poschke Katharina Lindner Lukas Bunse Iris Mildenberger Tamara Boschert Kristine J ähne Edward W Green Ingrid H ülsmeyer Simone J ünger Tobias Kessler Abigail K Suwala Philipp Eisele Michael O Breckwoldt Peter Vajkoczy Oliver M Gra Source Type: research
