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Cancer: Cancer
Drug: Methotrexate
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Total 688 results found since Jan 2013.
Differential benefit of metronomic chemotherapy among triple negative breast cancer subtypes treated in the IBCSG Trial 22-00
CONCLUSIONS: Our results show a differential benefit of low-dose CM therapy across different TNBC subtypes. Low-dose CM therapy could be considered as a potential immunomodulatory strategy for TNBC tumors with IM subtype in the early-disease setting.PMID:37733800 | DOI:10.1158/1078-0432.CCR-23-1267
Source: Clinical Cancer Research - September 21, 2023 Category: Cancer & Oncology Authors: Andrea Joaquin Garcia Mattia Rediti David Venet Samira Majjaj Roswitha Kammler Elisabetta Munzone Lorenzo Gianni Beat Th ürlimann Istv án Láng Marco Colleoni Sherene Loi Giuseppe Viale Meredith M Regan Laurence Buisseret Fran çoise Rothé Christos Sot Source Type: research
Dishevelled: An emerging therapeutic oncogene in human cancers
This study aimed to investigate the underlying molecular mechanism of DVL in cancer pathogenesis as well as to explore its importance in cancer diagnosis and prognosis as well as its role as a mediator in cancer chemotherapy.PMID:37683388 | DOI:10.1016/j.prp.2023.154793
Source: Pathology, Research and Practice - September 8, 2023 Category: Pathology Authors: Shadia Hamoud Alshahrani Nodir Rakhimov Arti Rana Hashem O Alsaab Ahmed Hjazi Mohaned Adile Munther Abosaooda Adeeb Abdulally Abdulhussien Alazbjee Ali Alsalamy Reza Mahmoudi Source Type: research
Nephroprotective effects of < em > Datura stramonium < /em > leaves against methotrexate nephrotoxicity via attenuation of oxidative stress-mediated inflammation and apoptosis in rats
CONCLUSION: DSLE has nephroprotective activity against MTX toxicity. However, further mechanistic studies are needed.PMID:37663387 | PMC:PMC10474919 | DOI:10.22038/AJP.2023.21903
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Esther U Alum Ademola C Famurewa Obasi U Orji Patrick M Aja Felix Nwite Simon E Ohuche Stanley C Ukasoanya Lucy O Nnaji Deborah Joshua Kingsley U Igwe Stephen F Chima Source Type: research
Network pharmacology analysis and clinical verification of Jishe Qushi capsules in rheumatoid arthritis treatment
Medicine (Baltimore). 2023 Aug 25;102(34):e34883. doi: 10.1097/MD.0000000000034883.ABSTRACTThe study aimed to elucidate the effective chemical composition and molecular mechanism of rheumatoid arthritis (RA) treatment with Jishe Qushi capsules (JSQS) and perform clinical validation. The effective chemical components were screened by a database. We used Cytoscape software to construct the key target-RA composite target network of JSQS. Gene Ontology biofunctional analysis and Kyoto encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed for the key targets, followed by molecular docking validatio...
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Yujie Li Nannan Zhang Xin Peng Wukai Ma Yuanxing Qin Xueming Yao Cong Huang Xudong Zhang Source Type: research
Synthesis of Quinazolin-2,4,6-triamine Derivatives as Non-purine Xanthine Oxidase Inhibitors and Exploration of Their Toxicological Potential
ChemMedChem. 2023 Aug 29:e202300184. doi: 10.1002/cmdc.202300184. Online ahead of print.ABSTRACTIn this work, a new set of quinazolin-2,4,6-triamine derivatives were synthesized to explore their potential biological activity as xanthine oxidase (XO) inhibitors, superoxide scavengers and screening of their toxicological profile. Among all the synthesized compounds, B1 exhibited better inhibitory activity against bovine xanthine oxidase (bXO) than allopurinol (IC50 =1.56 μM and IC50 =6.99 μM, respectively). As superoxide scavengers, B1, B2 and B13 exhibited a better effect than allopurinol (97.3 %, 82.1 %, 87.4 % and 69.4 ...
Source: ChemMedChem - August 29, 2023 Category: Chemistry Authors: Marcela A Lopez-Sanchez Mar ía Del Carmen Garcia-Rodriguez Rodrigo Aguayo-Ortiz Estefani Hernandez-Cruz Diego I Figueroa-Figueroa Francisco Hernandez-Luis Source Type: research
Protective effects of exogenous melatonin therapy against oxidative stress to male reproductive tissue caused by anti-cancer chemical and radiation therapy: a systematic review and meta-analysis of animal studies
ConclusionIn male rodents, melatonin therapy was related to improved testicular histopathology, reproductive hormones, testis and body weights, and reduced levels of oxidative markers in testicular tissues of male rodents. Future meticulous studies are recommended to provide a robust scientific backbone for human applications.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022355293, identifier CRD42022355293.
Source: Frontiers in Endocrinology - August 28, 2023 Category: Endocrinology Source Type: research
Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis
CONCLUSION: MTX is a promising chemotherapeutic agent for β-catenin hyperactive liver cancer. Since repurposing MTX has the advantages of lower risk, shorter timelines, and less investment in drug discovery and development, a clinical trial is warranted to test its efficacy in the treatment of β-catenin mutant liver cancer.PMID:37612257 | DOI:10.1097/CM9.0000000000002816
Source: Chinese Medical Journal - August 23, 2023 Category: General Medicine Authors: Fangming Liu Yuting Wu Baohui Zhang Shuhui Yang Kezhuo Shang Jie Li Pengju Zhang Weiwei Deng Linlin Chen Liang Zheng Xiaochen Gai Hongbing Zhang Source Type: research
