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Total 246 results found since Jan 2013.
Development of Biomembrane-mimetic Nanoparticles for the Treatment of Ischemic Stroke
Yakugaku Zasshi. 2021;141(9):1071-1078. doi: 10.1248/yakushi.21-00114.ABSTRACTIncrease in vascular permeability of the blood-brain barrier (BBB) is a distinct pathology following ischemic stroke. In previous studies, we demonstrated that liposomal drug delivery system (DDS)-based delivery of neuroprotectants is useful for treating cerebral ischemia/reperfusion injury. Additionally, our previous studies reported that combination therapy with liposomal fasudil plus tissue plasminogen activator (t-PA), a thrombolytic agent, brings about decrease in the risk of t-PA-derived cerebral hemorrhage and prolong the therapeutic time ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 2, 2021 Category: Drugs & Pharmacology Authors: Tatsuya Fukuta Source Type: research
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016
Sci Rep. 2022 Feb 28;12(1):3252. doi: 10.1038/s41598-022-06074-1.ABSTRACTTo determine whether increasing thrombectomy-capable hospitals with moderate comprehensive stroke center (CSC) capabilities is a valid alternative to centralization of those with high CSC capabilities. This retrospective, nationwide, observational study used data from the J-ASPECT database linked to national emergency medical service (EMS) records, captured during 2013-2016. We compared the influence of mechanical thrombectomy (MT) use, the CSC score, and the total EMS response time on the modified Rankin Scale score at discharge among patients with a...
Source: Cancer Control - March 1, 2022 Category: Cancer & Oncology Authors: Ai Kurogi Daisuke Onozuka Akihito Hagihara Kunihiro Nishimura Akiko Kada Manabu Hasegawa Takahiro Higashi Takanari Kitazono Tsuyoshi Ohta Nobuyuki Sakai Hajime Arai Susumu Miyamoto Tetsuya Sakamoto Koji Iihara J-ASPECT Study Collaborators Source Type: research
Stroke mortality in cancer survivors: A population-based study in Japan
The association between cancer survivors and stroke deaths remains unclear. We aimed to evaluate the risk of fatal stroke in patients with cancer.
Source: Thrombosis Research - January 9, 2023 Category: Hematology Authors: Yasufumi Gon, Ling Zha, Tsutomu Sasaki, Toshitaka Morishima, Yuko Ohno, Hideki Mochizuki, Tomotaka Sobue, Isao Miyashiro Source Type: research
Validation of an algorithm that determines stroke diagnostic code accuracy in a Japanese hospital-based cancer registry using electronic medical records
This study aimed to validate an algorithm that determines stroke diagnostic code accuracy, in a hospital-based cancer registry, using electronic medical records (EMRs) in Japan.
Source: BMC Medical Informatics and Decision Making - December 4, 2017 Category: Information Technology Authors: Yasufumi Gon, Daijiro Kabata, Keichi Yamamoto, Ayumi Shintani, Kenichi Todo, Hideki Mochizuki and Manabu Sakaguchi Tags: Research article Source Type: research
Utility of atherosclerosis-associated serum antibodies against colony-stimulating factor 2 in predicting the onset of acute ischemic stroke and prognosis of colorectal cancer
CONCLUSION: S-CSF2-Ab was useful for the diagnosis of atherosclerosis-related AIS, AMI, DM, and CKD and could discriminate poor prognosis, especially in p53-Ab-negative CRC.PMID:36844744 | PMC:PMC9954151 | DOI:10.3389/fcvm.2023.1042272
Source: Atherosclerosis - February 27, 2023 Category: Cardiology Authors: Shu-Yang Li Yoichi Yoshida Masaaki Kubota Bo-Shi Zhang Tomoo Matsutani Masaaki Ito Satoshi Yajima Kimihiko Yoshida Seiichiro Mine Toshio Machida Aiko Hayashi Minoru Takemoto Koutaro Yokote Mikiko Ohno Eiichiro Nishi Kenichiro Kitamura Ikuo Kamitsukasa Hir Source Type: research
