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Adenosine diphosphate-ribosylation factor-like 15 can regulate glycolysis and lipogenesis related genes in colon cancer
This study was designed to investigate the potential key genes of ADP-ribosylation factor-like 15 (ARL15) regulating glycolysis and lipogenesis in colon cancer. Hematoxylin-eosin (HE) staining and immunohistochemistry were used to observe the expression of ARL15 in 10 normal colon tissues and 10 colon cancer tissues. Immunofluorescence staining was used to observe the expression position of ARL15 in normal human colorectal mucosa cells (FHC) and colon cancer cells (HCT116 and SW620) with a confocal microscope. The ARL15 plasmid and small interfering RNA (siRNA) were constructed. After transfection, the expression levels of...
Source: Journal of Physiology and Pharmacology - October 27, 2022 Category: Drugs & Pharmacology Authors: F Du H-J Zhang W Shao Y-Y Tu K-J Yang L-S Piao Source Type: research

SOX2 function in cancers: Association with growth, invasion, stemness and therapy response
Biomed Pharmacother. 2022 Oct 19;156:113860. doi: 10.1016/j.biopha.2022.113860. Online ahead of print.ABSTRACTCancer is a leading cause of death worldwide and around 10 million deaths in 2020 were related to cancer. There are a number of therapeutic modalities for cancer such as chemotherapy, radiotherapy and surgery. However, tumor cells have capacity of developing resistance to chemotherapy and radiotherapy. Genetic mutations participate in development and progression of cancer. The current review focuses on the role of SOX2 transcription factor in cancer. SOX2 has capacity of increasing growth and metastasis of cancer c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 22, 2022 Category: Drugs & Pharmacology Authors: Sepideh Mirzaei Mahshid Deldar Abad Paskeh Maliheh Entezari Seyed Reza Mirmazloomi Aria Hassanpoor Maryam Aboutalebi Shamin Rezaei Elahe Sadat Hejazi Amirabbas Kakavand Hajar Heidari Shokooh Salimimoghadam Afshin Taheriazam Mehrdad Hashemi Saeed Samarghan Source Type: research

A perspective on oligonucleotide therapy: Approaches to patient customization
It is estimated that the human genome encodes 15% of proteins that are considered to be disease-modifying. Only 2% of these proteins possess a druggable site that the approved clinical candidates target. Due to this disparity, there is an immense need to develop therapeutics that may better mitigate the disease or disorders aroused by non-druggable and druggable proteins or enzymes. The recent surge in approved oligonucleotide therapeutics (OT) indicates the imminent potential of these therapies. Oligonucleotide-based therapeutics are of intermediate size with much-improved selectivity towards the target and fewer off-targ...
Source: Frontiers in Pharmacology - October 19, 2022 Category: Drugs & Pharmacology Source Type: research

The effect of neuropilin-1 silencing on the transforming growth factor- β1-mediated epithelial-mesenchymal transition of colon cancer SW480 cells and its effect on the proliferation and migration of colon cancer cells
In conclusion: silencing, NRP-1 in colon cancer SW480 cells can partially reverse TGF-β1-mediated EMT, reduce the proliferation activity of colon cancer cells, and slow their migration ability. Therefore, NRP-1 may become a new target for the treatment of colon cancer.PMID:36193963 | DOI:10.26402/jpp.2022.2.07
Source: J Physiol Pharmacol - October 4, 2022 Category: Drugs & Pharmacology Authors: B Zhu Q-Q Zhan Q-Y Liu X Yang Y-H Ge G-Y Ding S Guo W-G Xu Source Type: research

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