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Specialty: Drugs & Pharmacology
Cancer: Cancer
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Total 1000 results found since Jan 2013.
Dual Blockade of PD-1 and LAG3 Immune Checkpoints Increases Dendritic Cell Vaccine Mediated T Cell Responses in Breast Cancer Model
ConclusionThese findings strongly suggest that TMC-DS-L NPs loaded with siRNA could act as a novel tool in inhibiting the expression of immune checkpoints in the tumor microenvironment. Also, combination therapy based on inhibition of PD-1 and LAG3 in combination with DC vaccine is an effective method in treating cancer that needs to be further studied.
Source: Pharmaceutical Research - June 17, 2022 Category: Drugs & Pharmacology Source Type: research
The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line
This study aimed to investigate the pathophysiological functions of ET-2 in A549 human lung adenocarcinoma cells. We analyzed the expression of ET-2 mRNA in lung adenocarcinoma tissues compared to that in non-tumor lung tissues using public online databases. The function of ET-2 in A549 cells was investigated using siRNA. ET-2 mRNA level was upregulated in lung adenocarcinoma tissues, and high ET-2 level was associated with poor overall survival in patients with lung adenocarcinoma. ET-2 silencing reduced the proliferation, migration, invasion, and enhanced apoptosis in A549 cells. Mechanistically, ET-2 silencing reduced t...
Source: Canadian Journal of Physiology and Pharmacology - June 9, 2022 Category: Drugs & Pharmacology Authors: Ratih Paramita Suprapto Yoko Suzuki Tatsuya Nagano Ken-Ichi Hirata Noriaki Emoto Source Type: research
Combinational Silencing of Components Involved in JAK/STAT Signaling Pathway
In conclusion, the promising results of simultaneous targeting of JAK2 and gp 130 might be an example for potential combinatorial silencing strategies in cancer treatment.PMID:35680032 | DOI:10.1016/j.ejps.2022.106233
Source: European Journal of Pharmaceutical Sciences - June 9, 2022 Category: Drugs & Pharmacology Authors: Emira Bousoik Parvin Mahdipoor Abdulelah Alhazza Hamidreza Montazeri Aliabadi Source Type: research
The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line
This study aimed to investigate the pathophysiological functions of ET-2 in A549 human lung adenocarcinoma cells. We analyzed the expression of ET-2 mRNA in lung adenocarcinoma tissues compared to that in non-tumor lung tissues using public online databases. The function of ET-2 in A549 cells was investigated using siRNA. ET-2 mRNA level was upregulated in lung adenocarcinoma tissues, and high ET-2 level was associated with poor overall survival in patients with lung adenocarcinoma. ET-2 silencing reduced the proliferation, migration, invasion, and enhanced apoptosis in A549 cells. Mechanistically, ET-2 silencing reduced t...
Source: Canadian Journal of Physiology and Pharmacology - June 9, 2022 Category: Drugs & Pharmacology Authors: Ratih Paramita Suprapto Yoko Suzuki Tatsuya Nagano Ken-Ichi Hirata Noriaki Emoto Source Type: research
Combinational Silencing of Components Involved in JAK/STAT Signaling Pathway
In conclusion, the promising results of simultaneous targeting of JAK2 and gp 130 might be an example for potential combinatorial silencing strategies in cancer treatment.PMID:35680032 | DOI:10.1016/j.ejps.2022.106233
Source: European Journal of Pharmaceutical Sciences - June 9, 2022 Category: Drugs & Pharmacology Authors: Emira Bousoik Parvin Mahdipoor Abdulelah Alhazza Hamidreza Montazeri Aliabadi Source Type: research
The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line
This study aimed to investigate the pathophysiological functions of ET-2 in A549 human lung adenocarcinoma cells. We analyzed the expression of ET-2 mRNA in lung adenocarcinoma tissues compared to that in non-tumor lung tissues using public online databases. The function of ET-2 in A549 cells was investigated using siRNA. ET-2 mRNA level was upregulated in lung adenocarcinoma tissues, and high ET-2 level was associated with poor overall survival in patients with lung adenocarcinoma. ET-2 silencing reduced the proliferation, migration, invasion, and enhanced apoptosis in A549 cells. Mechanistically, ET-2 silencing reduced t...
Source: Canadian Journal of Physiology and Pharmacology - June 9, 2022 Category: Drugs & Pharmacology Authors: Ratih Paramita Suprapto Yoko Suzuki Tatsuya Nagano Ken-Ichi Hirata Noriaki Emoto Source Type: research
Molecular mechanism of the uptake and toxicity of EGF-LipoAgNPs in EGFR-overexpressing cancer cells
Biomed Pharmacother. 2022 Jun;150:113085. doi: 10.1016/j.biopha.2022.113085. Epub 2022 May 10.ABSTRACTThe surface of silver nanoparticles (AgNPs) is characterized by high reactivity resulting in prooxidative and cytotoxic properties. These effects are observed both in normal and in cancer cells, which overexpress the Epidermal Growth Factor Receptor (EGFR). In our previous paper, we have demonstrated that, with the use of liposomes labeled with the Epidermal Growth Factor (EGF), it is possible to direct the toxic effect of AgNPs in EGFR-overexpressing cells. Unfortunately, the mechanism of uptake and toxicity induction by ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 5, 2022 Category: Drugs & Pharmacology Authors: Bartosz Sk óra Konrad A Szychowski Source Type: research
Hypoxia-Induced Upregulation of lncRNA ELFN1-AS1 Promotes Colon Cancer Growth and Metastasis Through Targeting TRIM14 via Sponging miR-191-5p
In conclusion, ELFN1-AS1 operates as a downstream target of hypoxia, promotes proliferation and invasion, and inhibits apoptosis through upregulating TRIM14 by sponging miR-191-5p in the colon cancer cells. Our results enrich our understanding of colon cancer progression and provide potential targets for clinical treatment of colon cancer.
Source: Frontiers in Pharmacology - May 16, 2022 Category: Drugs & Pharmacology Source Type: research
Screening of and mechanism underlying the action of serum- and glucocorticoid-regulated kinase 3-targeted drugs against estrogen receptor-positive breast cancer
This study provides an experimental and theoretical basis for the research and development of new anti-ER + breast cancer drugs.PMID:35569550 | DOI:10.1016/j.ejphar.2022.174982
Source: European Journal of Pharmacology - May 15, 2022 Category: Drugs & Pharmacology Authors: Duanfang Zhou Xiaoping Yu Yi Song Hongfang Zeng Huan Zhang Bo Chen Yalan Wang Hongyao Li Xu Liu Qichen He Xiaoli Li Weiying Zhou Source Type: research
Antidepressants Fluoxetine Mediates Endoplasmic Reticulum Stress and Autophagy of Non –Small Cell Lung Cancer Cells Through the ATF4-AKT-mTOR Signaling Pathway
This study mainly focused on the discovery of the molecular basis of the inhibitory effect of fluoxetine in lung cancer. The specific anti-proliferation effect and autophagy induced by fluoxetine on lung cancer cell were shown in CCK8 and immunofluorescence. The RNA sequence hinted that the endoplasmic reticulum (ER) stress-related protein and mTOR pathway were enriched after fluoxetine treatment. Western blot results revealed that the ER stress pathway was activated by fluoxetine, including PERK, ATF4, and CHOP, while the AKT/mTOR pathway was inhibited. In addition, the transfection of ATF4 siRNA further discovered that E...
Source: Frontiers in Pharmacology - May 10, 2022 Category: Drugs & Pharmacology Source Type: research
Comprehensive Analysis of the Potential Immune-Related Biomarker ATG101 that Regulates Apoptosis of Cholangiocarcinoma Cells After Photodynamic Therapy
Autophagy related gene 101 (ATG101) plays a significant role in the occurrence and development of tumours by responding to stress. Our research aims to illustrate the correlation between the expression of ATG101 and tumor prognosis and its potential role and mechanism in tumor immunity and photodynamic therapy (PDT). First, integrated analysis of The Cancer Genome Atlas and Genotype-Tissue Expression portals were used to analyse the expression of ATG101. Then, Kaplan–Meier curves was applied in cholangiocarcinoma (CHOL) and liver hepatocellular carcinoma (LIHC) datasets for survival analysis. Next, the relationship betwe...
Source: Frontiers in Pharmacology - May 3, 2022 Category: Drugs & Pharmacology Source Type: research
