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Nutrition: Herbs
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Total 89 results found since Jan 2013.
Leonurine suppresses prostate cancer growth < em > in vitro < /em > and < em > in vivo < /em > by regulating miR-18a-5p/SLC40A1 axis
This study further unveiled the mechanism by which Leo inhibited prostate cancer progression, which provides a promising potential for its future clinical application.PMID:36588358 | DOI:10.4103/0304-4920.365459
Source: The Chinese Journal of Physiology - January 2, 2023 Category: Physiology Authors: Bin Liang Shouxi Cui Songnian Zou Source Type: research
Synthesis and anti-melanoma effect of 3-O-prenyl glycyrrhetinic acid against B16F10 cells via induction of endoplasmic reticulum stress-mediated autophagy through ERK/AKT signaling pathway
In this study, 4-phenylbutyric acid (4PBA, a chemical chaperone) and small interference RNA (siRNA) knockdown of C/EBP Homologous Protein (CHOP)/growth arrest- and DNA damage-inducible gene 153(GAD153) blocked NPC-402-mediated autophagy induction, thus confirming the role of ER stress and autophagy in melanoma cell death. NPC-402 induced oxidative stress and apoptosis in melanoma cells, which were effectively mitigated by treatment with N-acetylcysteine (NAC). In vivo studies showed that intraperitoneal (i.p.) injection of NPC-402 at 10 mg/kg (5 days in 1 week) significantly retarded angiogenesis in the Matrigel plug assay...
Source: Frontiers in Oncology - August 2, 2022 Category: Cancer & Oncology Source Type: research
Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation
Biochem Biophys Res Commun. 2021 Dec 1;587:99-106. doi: 10.1016/j.bbrc.2021.11.101. Online ahead of print.ABSTRACTColorectal cancer (CRC) is one of the most common malignant tumors in the digestive system, and Chinese herbal medicine plays an important role in tumor treatment. The in-depth study of auriculasin isolated from Flemingia philippinensis showed that auriculasin promoted reactive oxygen species (ROS) generation in a concentration-dependent manner; when ROS scavenger NAC was added, the effects of auriculasin in promoting ROS generation and inhibiting cell viability were blocked. Auriculasin induced CRC cell apopto...
Source: Biochemical and Biophysical Research communications - December 6, 2021 Category: Biochemistry Authors: Chun-Xiao Wang Li-Hua Chen Hai-Bin Zhuang Ze-Sheng Shi Zhi Chuan Chen Jian-Peng Pan Zhong-Shi Hong Source Type: research
Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1 α/BNIP3 to inhibit mitochondrial apoptosis pathway
Biomed Pharmacother. 2021 Aug 9;142:111965. doi: 10.1016/j.biopha.2021.111965. Online ahead of print.ABSTRACTCisplatin (CDDP) may induce apoptosis of renal tubular epithelial cells (RTEC) and cause CDDP-induced acute kidney injury (CAKI) during cancer treatment, but yet lack of preventive measures and effective treatment. As a new Chinese herbal preparation, Panax notoginseng saponins (PNS) has been found to mitigate CDDP-induced CAKI through elevating the expression of HIF-1α in the rat model, according to the data from our previous works. However, the underlying link between HIF-1α and apoptosis has not been well eluci...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 13, 2021 Category: Drugs & Pharmacology Authors: Qingqing Li Yansong Zhang Yufang Yang Songqing Huang Xiaoqin Zou Congying Wei Taolin Liang Xiaobin Zhong Source Type: research
