• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Unraveling the role of Breg cells in digestive tract cancer and infectious immunity
Over the past two decades, regulatory B cells (Breg cells or Bregs) have emerged as an immunosuppressive subset of B lymphocytes playing a key role in inflammation, infection, allergy, transplantation, and cancer. However, the involvement of Bregs in various pathological conditions of the gastrointestinal tract is not fully understood and is the subject of much recent research. In this review, we aimed to summarize the current state of knowledge about the origin, phenotype, and suppressive mechanisms of Bregs. The relationship between the host gut microbiota and the function of Bregs in the context of the disturbance of mu...
Source: Frontiers in Immunology - December 23, 2022 Category: Allergy & Immunology Source Type: research

Dupilumab induced hypereosinophilic syndrome (hes)
We describe a case of HES manifesting with altered mental status two months after starting therapy with dupilumab.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: A. Abulhamail, T. Kelbel, J. Lin, L. Funderburk Tags: M028 Source Type: research

TSLP, IL-33, and IL-25: not just for allergy and helminth infection
The release of cytokines from epithelial and stromal cells is critical for the initiation and maintenance of tissue immunity. Three such cytokines, TSLP, IL-33, and IL-25, are important regulators of type 2 immune responses triggered by parasitic worms and allergens. In particular, these cytokines activate group 2 innate lymphoid cells (ILC2s), Th2 cells, and myeloid cells that drive hallmarks of type 2 immunity. However, emerging data indicates that these tissue-associated cytokines are not only involved in canonical type 2 responses, but are also important in the context of viral infections, cancer, and even homeostasis.
Source: Journal of Allergy and Clinical Immunology - July 18, 2022 Category: Allergy & Immunology Authors: Alison G. Stanbery, Shuchi Smita, Jakob von Moltke, Elia D. Tait Wojno, Steven F. Ziegler Source Type: research

Emerging Paradigms in Type 2 Immunity
Annu Rev Immunol. 2022 Apr 26;40:443-467. doi: 10.1146/annurev-immunol-101320-030339.ABSTRACTA principal purpose of type 2 immunity was thought to be defense against large parasites, but it also functions in the restoration of homeostasis, such as toxin clearance following snake bites. In other cases, like allergy, the type 2 T helper (Th2) cytokines and cells present in the environment are detrimental and cause diseases. In recent years, the recognition of cell heterogeneity within Th2-associated cell populations has revealed specific functions of cells with a particular phenotype or gene signature. In addition, here we d...
Source: Annual Review of Immunology - April 26, 2022 Category: Allergy & Immunology Authors: Hamida Hammad Nincy Debeuf Helena Aegerter Andrew S Brown Bart N Lambrecht Source Type: research

Pages: 1  2  3  4