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Occam ’s Razor Versus Hickam’s Dictum in a Presentation of STEMI
A 79-year-old female presented with an inferolateral STEMI on a background of a recent multi-territorial stroke, hypertension, hypercholesterolaemia, and prior thyroidectomy for thyroid cancer. Percutaneous intervention involved a drug-eluting balloon to the culprit oblique marginal artery and medically managed calcified 80% ostial right coronary artery (RCA). New paroxysmal atrial fibrillation (AF) was noted. Transthoracic echocardiogram revealed a 13x7 mm mobile aortic valve mass with mild regurgitation.
Source: Heart, Lung and Circulation - July 1, 2023 Category: Cardiology Authors: T. Tran, V. Dang, K. Cho, J. Cham, T. Nguyen Source Type: research

Insulin Regulation of Hepatic Lipid Homeostasis
Compr Physiol. 2023 Jun 26;13(3):4785-4809. doi: 10.1002/cphy.c220015.ABSTRACTThe incidence of obesity, insulin resistance, and type II diabetes (T2DM) continues to rise worldwide. The liver is a central insulin-responsive metabolic organ that governs whole-body metabolic homeostasis. Therefore, defining the mechanisms underlying insulin action in the liver is essential to our understanding of the pathogenesis of insulin resistance. During periods of fasting, the liver catabolizes fatty acids and stored glycogen to meet the metabolic demands of the body. In postprandial conditions, insulin signals to the liver to store exc...
Source: Atherosclerosis - June 26, 2023 Category: Cardiology Authors: Kahealani Uehara Dominic Santoleri Anna E Garcia Whitlock Paul M Titchenell Source Type: research

Nuts and seeds consumption and risk of cardiovascular disease, type 2 diabetes and their risk factors: a systematic review and meta-analysis
CONCLUSION: There is a probable relationship between consumption of nuts/seeds and lower risk of CVD, mostly driven by CHD, possibly in part through effects on blood lipids. More research on stroke and T2D may affect the conclusions. The evidence of specific nuts should be further investigated.PMID:36816545 | PMC:PMC9930735 | DOI:10.29219/fnr.v67.8961
Source: Atherosclerosis - February 23, 2023 Category: Cardiology Authors: Erik Kristoffer Arnesen Birna Thorisdottir Linnea B ärebring Fredrik S öderlund Bright I Nwaru Ulrike Spielau Jutta Dierkes Alfons Ramel Christel Lamberg-Allardt Agneta Åkesson Source Type: research

Association Between Achieved Low-Density Lipoprotein Cholesterol Levels and Long-Term Cardiovascular and Safety Outcomes: An Analysis of FOURIER-OLE
CONCLUSIONS: In patients with atherosclerotic cardiovascular disease, long-term achievement of lower LDL-C levels, down to <20 mg/dL (<0.5 mmol/L), was associated with a lower risk of cardiovascular outcomes with no significant safety concerns.REGISTRATION: URL: https://www.CLINICALTRIALS: gov; Unique identifier: NCT01764633.PMID:36779348 | DOI:10.1161/CIRCULATIONAHA.122.063399
Source: Atherosclerosis - February 13, 2023 Category: Cardiology Authors: Prakriti Gaba Michelle L O'Donoghue Jeong-Gun Park Stephen D Wiviott Dan Atar Julia F Kuder KyungAh Im Sabina A Murphy Gaetano M De Ferrari Zbigniew A Gaciong Kalman Toth Ioanna Gouni-Berthold Jose Lopez-Miranda Fran çois Schiele Fran çois Mach Jose H F Source Type: research

Does a History of Cancer Influence the Effectiveness of Statins on Outcomes After Stroke?
CONCLUSIONS: Treatment with statins after ischemic stroke may confer additional survival benefits for people who also have had cancer.PMID:36065808 | DOI:10.1161/STROKEAHA.122.038829
Source: Atherosclerosis - September 6, 2022 Category: Cardiology Authors: Muideen T Olaiya Nadine E Andrew Lachlan L Dalli David Ung Joosup Kim Vijaya Sundararajan Dominique A Cadilhac Amanda G Thrift Mark R Nelson Leonid Churilov Monique F Kilkenny PRECISE Investigators Source Type: research

De Novo Sphingolipid Biosynthesis in Atherosclerosis
Adv Exp Med Biol. 2022;1372:31-46. doi: 10.1007/978-981-19-0394-6_3.ABSTRACTAtherosclerosis is the formation of fibrofatty lesions in the arterial wall, and this inflammatory state of the artery is the main cause of advanced pathological processes, including myocardial infarction and stroke. Dyslipidemic conditions with excess cholesterol accumulate within the arterial vessel wall and initiate atherogenic processes. Following vascular reaction and lipid accumulation, the vascular wall gradually thickens. Together with the occurrence of local inflammation, early atherosclerotic lesions lead to advanced pathophysiological ev...
Source: Atherosclerosis - May 3, 2022 Category: Cardiology Authors: Tae-Sik Park Shivani Devi Amitesh Sharma Goon-Tae Kim Kyung-Hee Cho Source Type: research

Comparing pharmacotherapy in MINOCA versus medically managed obstructive acute coronary syndrome
This study uniquely compares the management and outcomes of MINOCA patients with a medically managed obstructive ACS (M-ACS) population. We retrospectively analysed registry data for consecutive patients admitted to the Gold Coast University Hospital with ACS requiring coronary angiography and identified patients with MINOCA and M-ACS. Baseline characteristics, pharmacological therapy and in-hospital outcomes were compared. In hospital outcomes were composite NACE, heart failure, stroke and major bleeding. Multivariate regression analysis was also performed to identify independent predictors of MINOCA. Multivariate regress...
Source: Heart and Vessels - March 23, 2022 Category: Cardiology Source Type: research

Le LDL-cholest érol : une brique supplémentaire dans le mur de l'athérosclérose
Ann Cardiol Angeiol (Paris). 2022 Jan 14:S0003-3928(21)00167-0. doi: 10.1016/j.ancard.2021.10.020. Online ahead of print.ABSTRACTAtherosclerosis is one of the two major causes of mortality worldwide along with cancer and is responsible for myocardial infarction, stroke, and arteritis. Its pathophysiology is still partially understood which allows doubts referring to the preventive and curative treatments. Population screening for atherosclerosis remains marginal even though it should be the common practice. To encourage preventive screening and therapies, we propose a simple and easily understandable pathophysiology of ath...
Source: Atherosclerosis - January 18, 2022 Category: Cardiology Authors: Adrien Pasteur-Rousseau Alain Tedgui Source Type: research

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