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Role of the pioneer transcription factor GATA2 in health and disease
J Mol Med (Berl). 2023 Aug 25. doi: 10.1007/s00109-023-02359-8. Online ahead of print.ABSTRACTThe transcription factor GATA2 is involved in human diseases ranging from hematopoietic disorders, to cancer, to infectious diseases. GATA2 is one of six GATA-family transcription factors that act as pioneering transcription factors which facilitate the opening of heterochromatin and the subsequent binding of other transcription factors to induce gene expression from previously inaccessible regions of the genome. Although GATA2 is essential for hematopoiesis and lymphangiogenesis, it is also expressed in other tissues such as the ...
Source: Atherosclerosis - August 25, 2023 Category: Cardiology Authors: Amena Aktar Bryan Heit Source Type: research

Exploring the potential mechanism of action of ursolic acid against gastric cancer and COVID-19 using network pharmacology and bioinformatics analysis
CONCLUSION: This study found that in patients with gastric cancer and COVID-19, UA may bind to ACE2, regulate core targets such as PARP1 and MAPK14, and the PI3K/Akt signaling pathway, and participate in antiinflammatory, anti-oxidation, anti-virus, and immune regulation to exert therapeutic effects.PMID:37218202 | DOI:10.2174/1381612829666230510124716
Source: Current Pharmaceutical Design - May 23, 2023 Category: Drugs & Pharmacology Authors: Zhiyao Liu Hailiang Huang Ying Yu Yuqi Jia Lingling Li Xin Shi Fangqi Wang Source Type: research

Auto-Kla: a novel web server to discriminate lysine lactylation sites using automated machine learning
Brief Bioinform. 2023 Mar 3:bbad070. doi: 10.1093/bib/bbad070. Online ahead of print.ABSTRACTRecently, lysine lactylation (Kla), a novel post-translational modification (PTM), which can be stimulated by lactate, has been found to regulate gene expression and life activities. Therefore, it is imperative to accurately identify Kla sites. Currently, mass spectrometry is the fundamental method for identifying PTM sites. However, it is expensive and time-consuming to achieve this through experiments alone. Herein, we proposed a novel computational model, Auto-Kla, to quickly and accurately predict Kla sites in gastric cancer ce...
Source: Briefings in Bioinformatics - March 4, 2023 Category: Bioinformatics Authors: Fei-Liao Lai Feng Gao Source Type: research

Effect of DPP4/CD26 expression on SARS ‑CoV‑2 susceptibility, immune response, adenosine (derivatives m < sup > 6 < /sup > < sub > 2 < /sub > A and CD) regulations on patients with cancer and healthy individuals
Int J Oncol. 2023 Mar;62(3):41. doi: 10.3892/ijo.2023.5489. Epub 2023 Feb 17.ABSTRACTThe worldwide COVID‑19 pandemic was brought on by a new coronavirus (SARS Cov‑2). A marker/receptor called Dipeptidyl peptidase 4/CD26(DPP4/CD26) may be crucial in determining susceptibility to tumors and coronaviruses. However, the regulation of DPP4 in COVID‑invaded cancer patients and its role on small molecule compounds remain unclear. The present study used the Human Protein Atlas, Monaco, and Schmiedel databases to analyze the expression of DPP4 in human tissues and immune cells. The association between DPP4 expression and surv...
Source: International Journal of Oncology - February 17, 2023 Category: Cancer & Oncology Authors: Jiaman Du Jiewen Fu Wenqian Zhang Lianmei Zhang Hanchun Chen Jingliang Cheng Tao He Junjiang Fu Source Type: research

Human Proteome Microarray identifies autoantibodies to tumor-associated antigens as serological biomarkers for the diagnosis of hepatocellular carcinoma
In conclusion, the panel of 6 TAAbs can provide potential value for HCC detection, and the strategy to identify novel serological biomarkers can also provide new clues in understanding immunodiagnostic biomarkers.PMID:36587394 | DOI:10.1002/1878-0261.13371
Source: Cancer Control - January 1, 2023 Category: Cancer & Oncology Authors: Qian Yang Hua Ye Guiying Sun Keyan Wang Liping Dai Cuipeng Qiu Jianxiang Shi Jicun Zhu Xiao Wang Peng Wang Source Type: research

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