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Cancer: Gastric (Stomach) Cancer
Drug: Aspirin
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Total 23 results found since Jan 2013.
Low-dose acetylsalicylic acid for cancer prevention considering risk factors: A retrospective cohort study
CONCLUSIONS: Our results suggest that aspirin intake is associated with a reduced incidence of colorectal, pancreatic, and prostate cancers and lymphomas.PMID:37302674 | DOI:10.1016/j.annepidem.2023.06.002
Source: Annals of Epidemiology - June 11, 2023 Category: Epidemiology Authors: D ídac Florensa Jordi Mateo Francesc Solsona Leonardo Galv án Miquel Mesas Ramon Pi ñol Leonardo Espinosa-Leal Pere Godoy Source Type: research
Combining gamma-tocopherol and aspirin synergistically suppresses colitis-associated colon tumorigenesis and modulates the gut microbiota in mice, and inhibits the growth of human colon cancer cells
Eur J Pharmacol. 2023 Mar 13:175656. doi: 10.1016/j.ejphar.2023.175656. Online ahead of print.ABSTRACTDespite being shown to be effective for chemoprevention of colorectal cancer, aspirin has limitations including adverse effects and inability to block colitis-associated colon cancer (CAC). γ-Tocopherol (γT), a vitamin E form, has been reported to mitigate experimental colitis and CAC, prolong the anti-inflammatory activity of aspirin and alleviate aspirin-induced adverse effect. We therefore hypothesize that combining γT and aspirin is better than either compound singly for suppressing CAC. This hypothesis was tested i...
Source: European Journal of Pharmacology - March 15, 2023 Category: Drugs & Pharmacology Authors: Kilia Y Liu Qianyue Wang Cindy H Nakatsu Yava Jones-Hall Qing Jiang Source Type: research
Diet quality and risk of gastric adenocarcinoma: The Multiethnic Cohort
CONCLUSIONS: In a multiethnic population, we did not observe overall significant associations between these dietary quality indices and risk of gastric cancer. However, among former aspirin users and never smokers, there could be a reduction of gastric distal adenocarcinoma risk with a higher adherence to a Mediterranean diet.PMID:36789943 | DOI:10.1016/j.ajcnut.2022.11.009
Source: The American Journal of Clinical Nutrition - February 15, 2023 Category: Nutrition Authors: Nicholas Acuna Song-Yi Park Lo ïc Le Marchand James R H ébert Carol Boushey Lynne R Wilkens Anna H Wu V Wendy Setiawan Source Type: research
Gel immersion endoscopic mucosal resection in early gastric cancer with bleeding: A case report
Ann Med Surg (Lond). 2022 Sep 21;82:104743. doi: 10.1016/j.amsu.2022.104743. eCollection 2022 Oct.ABSTRACTGel immersion endoscopy was developed by Yano for the treatment of bleeding. In this case, we performed gel immersion endoscopic mucosal resection to treat a bleeding gastric cancer. An 80-year-old man, with chronic renal failure and on aspirin treatment for ischemic heart disease, underwent endoscopic treatment for multiple early gastric cancers on the anterior and posterior walls of the pyloric ring. An endoscopic submucosal dissection was performed for gastric cancer on the anterior wall; however, the removal of the...
Source: Cancer Control - October 21, 2022 Category: Cancer & Oncology Authors: Daisuke Suto Masashi Yoshida Takaaki Otake Yosuke Osawa Takayuki Akita Kiichi Sato Hidehiko Yamada Hironori Odaira Yutaka Suzuki Yutaka Kohgo Source Type: research
Effect of frequently prescribed drugs on gastric cancer risk
Best Pract Res Clin Gastroenterol. 2021 Mar-Apr;50-51:101741. doi: 10.1016/j.bpg.2021.101741. Epub 2021 Mar 16.ABSTRACTGastric cancer is the fifth leading cancer worldwide. Infection with Helicobacter pylori represents the major risk factor, but only a small fraction of infected individuals will develop neoplasia. The progression of advanced gastric lesions to cancer is influenced by characteristics of the bacterial strain, host genetic and environmental factors. Recently, the effect of medications on gastric cancer risk has gained interest, because many commonly prescribed drugs affect gastric homeostasis. While non-stero...
Source: Clin Med Res - May 12, 2021 Category: Research Authors: Theresa Weltermann Christian Schulz Lukas Macke Source Type: research
Preparation of novel anthraquinone-based aspirin derivatives with anti-cancer activity
In this study, we synthesized two novel anthraquinone-based aspirin derivatives, Asp-X3 and Asp-X3-CH3, with therapeutic potential for gastric cancer. The structures of the two compounds were determined by 1D-, 2D-NMR, and High-Resolution Mass (HRSM). Asp-X3 and Asp-X3-CH3 could inhibit the growth of gastric cancer cells (SGC7901), yielding IC50 values 10-fold lower than that of Aspirin. Asp-X3 and Asp-X3-CH3 were less toxic to gastric mucosal cells, yielding IC50 values that were about 2-fold higher than the corresponding IC50 values determined with SGC7901 cells. Asp-X3-CH3 and Asp-X3 also induced SGC7901 cells to underg...
Source: European Journal of Pharmacology - March 20, 2021 Category: Drugs & Pharmacology Authors: Shan Lin Yue Zhang Zeyu Wang Shuang Zhang Yingjie Li Yuhua Fan Dan Li Sen Li Yuhua Bai Source Type: research
