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Total 5325 results found since Jan 2013.

Phageome based vaccination and human innate immune modulation could be a useful strategy to control human Coronavirus infections
J Biol Regul Homeost Agents. 2021 May 26;35(3). doi: 10.23812/20-592-A. Online ahead of print.ABSTRACTHuman Coronavirus (CoV) infections, including SARS-COV, MERS-COV, and SARS-CoV-2, usually cause fatal lower and upper respiratory tract infections due to exacerbated expression of pro-inflammatory cytokines and chemokines. We aim to summarize different aspects, such as CoV immune evasion mechanisms and host innate immune response to these infections, and their role in pathogenesis. We have also elaborated the up-to-date findings on different vaccine development strategies and progress against CoVs in both humans and non-hu...
Source: Journal of Biological Regulators and Homeostatic Agents - May 27, 2021 Category: Biomedical Science Authors: M Abaidullah S Peng M Kamran X Song A Ali Sher Y Chen A Rehman L Lin R Jia Z Yin Source Type: research

Completed absorption of coronavirus disease 2019 (COVID-19) pneumonia lesions: a preliminary study
Conclusion: The pulmonary lesions in some mild COVID-19 patients (generally with normal laboratory indicators at admission, GGOs as the main manifestation on initial CT, and representation of continuous absorption after treatment) could be completely absorbed with a mean duration of 31.6 days.PMID:33967608 | PMC:PMC8100646 | DOI:10.7150/ijms.54675
Source: International Journal of Medical Sciences - May 10, 2021 Category: Biomedical Science Authors: Xue-Yan Liu Fa-Jin Lv Sheng-Xiu Lv Bin-Jie Fu Wang-Jia Li Md Yu Ouyang Zhi-Gang Chu Source Type: research

Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D
Worse outcomes occur in aged compared with young populations after infections with respiratory viruses, including pathogenic coronaviruses (SARS-CoV, MERS-CoV, and SARS-CoV-2), and are associated with a suboptimal lung milieu (“inflammaging”). We previously showed that a single inducible phospholipase, PLA2G2D, is associated with a proresolving/antiinflammatory response in the lungs, and increases with age. Survival was increased in naive Pla2g2d–/– mice infected with SARS-CoV resulting from augmented respiratory dendritic cell (rDC) activation and enhanced priming of virus-specific T cells. Here, in contrast, we s...
Source: Journal of Clinical Investigation - June 1, 2021 Category: Biomedical Science Authors: Jian Zheng, David Meyerholz, Lok-Yin Roy Wong, Michael Gelb, Makoto Murakami, Stanley Perlman Source Type: research

Body mass index and severity/fatality from coronavirus disease 2019: A nationwide epidemiological study in Korea
This study included 4,141 COVID-19 patients who were released from isolation or had died as of April 30, 2020. This nationwide data was provided by the Korean Centers for Disease Control and Prevention Agency. BMI was categorized as follows;
Source: PLoS One - June 22, 2021 Category: Biomedical Science Authors: In Sook Kang Source Type: research

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